Search Results for: necrobiosis

Histologic Diagnosis of Inflammatory Skin Diseases

Limitations of the Algorithmic Method

…is being all that now is awry (see Fig. 5.139) or of fibroplasia absent any hint of granulomatous inflammation at the end of necrobiosis lipoidica. Melanophages when a sign of postinflammatory pigmentary alteration are not, in themselves, indicative…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…erol clefts, mononuclear foam cells, and multinucleate Touton giant cells being findings expected in the disease, but not in necrobiosis lipoidica. 10.68.4A: Perivascular and interstitial dermatitis, and panniculitis, lobular + 10.68.4B:…

Histologic Diagnosis of Inflammatory Skin Diseases

Cells That Mediate Inflammation (Inflammatory Cells)

…e death of tissue simultaneous with replacement of it by what they considered to be viable tissue. We eschew the term “necrobiosis” because it is so imprecise and thereby impedes communication. Moreover, it is completely unnecessary. The…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Churg-Strauss Granuloma and Allergic Granulomatosis?

…a annulare—like histology in the spectrum of vasculitis. Eur J Dermatol 1993;3:175–79. “Extravascular granuloma: Focal necrobiosis with peripheral palisading histiocytic granuloma was the prominent feature in three patients. The findings of a…

Histologic Diagnosis of Inflammatory Skin Diseases

Algorithms Predicated on “Nonspecific” Findings

…with arthritis + Degenerated collagen in the center of palisades (early) and crowded, thickened bundles of collagen (late) = Necrobiosis lipoidica + Extensive degeneration of collagen, cholesterol clefts, and necrotic inflammatory cells in the…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Actinic Granuloma?

…differ substantially from granuloma annulare because of the predominant elastolysis and elastophagocytosis in the absence of necrobiosis and palisading granuloma.” Limas C. The spectrum of primary cutaneous elastolytic granulomas and their…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Study By Disease

…que (Quiz #558) Mycosis fungoides, plaque and patch stages (Quiz #632) Myiasis (Quiz #604) Necrobiosis lipoidica (Quiz #184) Necrobiosis lipoidica (Quiz #185) Necrobiosis lipoidica (Quiz #262) Necrobiosis lipoidica (Quiz #301) Necrobiosis lipoidica…

Differential Diagnosis in Dermatopathology

Xanthogranuloma vs. Necrobiotic xanthogranuloma

A granulomatous inflammatory process characterized clinically by patches that become yellowish plaques and that in time resolve with atrophy and telangiectases. The condition usually occurs in persons with diabetes.

Actinic granuloma

Actinic granuloma

…giant cells, which phagocytize the degenerated elastic fibers, a process known as elastophagocytosis. There is an absence of necrobiosis, such as facial necrobiosis lipoidica, or mucinosis, such as GA or sarcoid-like granuloma in the dermis at the…

Histologic Diagnosis of Inflammatory Skin Diseases

Miescher’s granuloma of the face

…embling leprosy. Int J Lepr 1964;32: 368–70. Mehregan AH, Altman J. Miescher’s granuloma of the face. A variant of the necrobiosis lipoidica-granuloma annulare spectrum. Arch Dermatol 1973;107:62–64. O’Brien JP. Actinic granuloma. An…