Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Churg-Strauss Granuloma and Allergic Granulomatosis?

“The occurrence of a clinical syndrome of severe asthma, fever, and hypereosinophilia, together with symptoms of vascular embarrassment in various organ systems, has been established. . . . The basic anatomical changes . . . consisted of wide…

Histologic Diagnosis of Inflammatory Skin Diseases

Algorithms Predicated on “Nonspecific” Findings

In this section, algorithms used to reach specific diagnosis are predicated on “nonspecific” findings recognized best at higher magnification. Other changes requisite for specific diagnoses, i.e., denominators that are essential, then ar…

Histologic Diagnosis of Inflammatory Skin Diseases

Cells That Mediate Inflammation (Inflammatory Cells)

Neutrophils, eosinophils, lymphocytes, plasma cells, and histiocytes are called inflammatory cells because they enter tissue during the process of inflammation. A more exact designation for them is “cells of an inflammatory process”; the…

Histologic Diagnosis of Inflammatory Skin Diseases

Study By Disease

…oides, plaque and patch stages (Quiz #632) Myiasis (Quiz #604) Necrobiosis lipoidica (Quiz #184) Necrobiosis lipoidica (Quiz #185) Necrobiosis lipoidica (Quiz #262) Necrobiosis lipoidica (Quiz #301) Necrobiosis lipoidica (Quiz #490) Necrobiosis lipoi…

Differential Diagnosis in Dermatopathology

Discussions

Criteria for differentiation of xanthogranuloma from necrobiotic xanthogranuloma pertain to lesions of xanthogranuloma that are developed fully and of necrobiotic xanthogranuloma that are evolving still. These two conditions, at those different stag…

Histologic Diagnosis of Inflammatory Skin Diseases

Miescher’s granuloma of the face

Miescher’s granuloma of the face Presentation stereotypical Age and sex Women Distribution of lesions Face and scalp Configuration of lesions Annular Individual lesions Plaques Course Resolving after many months Differential diagnosis clinical…

Differential Diagnosis in Dermatopathology

Xanthogranuloma vs. Necrobiotic xanthogranuloma

A granulomatous inflammatory process characterized clinically by patches that become yellowish plaques and that in time resolve with atrophy and telangiectases. The condition usually occurs in persons with diabetes….

Histologic Diagnosis of Inflammatory Skin Diseases

Applicable Terms

ABSCESS [L. abscessus (a going away)]: Clinically, a circumscribed collection of pus and histopathologically a localized collection of neutrophils. An abscess may form in the epidermis, both surface and infundibular, eccrine ducts, dermis, and subcu…

Histologic Diagnosis of Inflammatory Skin Diseases

The Algorithmic Method

An algorithm is a method for calculation based on logical thought and orderly sequence, one that can be utilized for diagnosis of diseases of all kinds, including inflammatory ones of the skin. Once a disorder of the skin and/or subcutaneous fat has…

Histologic Diagnosis of Inflammatory Skin Diseases

Errors and Reasons

Error: Abortive is an accurate modifier of particular pathologic processes, e.g., abortive dermatofibroma, abortive morphea, and abortive T-cell lymphoma. Reason: The idea itself is abortive! For example, what is called “abortive T-cell lympho…