Histologic Diagnosis of Inflammatory Skin Diseases

Cells That Mediate Inflammation (Inflammatory Cells)

…necrobiotic granulomas.” The meaning of the word “necrobiosis” is opaque because it is an oxymoron, implying as it does a condition (-osis) of life (-bio-) and death (necro-) together. Dermatopathologists of yore used the term to de…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Actinic Granuloma?

…has led to debates about whether lesions were truly those of necrobiosis lipoidica diabeticorum, on one hand, or of granuloma disciformis, on the other; of granuloma annulare on the face or of Miescher’s granuloma of the face; of erythema elev…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Churg-Strauss Granuloma and Allergic Granulomatosis?

…anuloma, rheumatoid papule, superficial ulcerating rheumatoid necrobiosis, and interstitial granulomatous dermatitis with arthritis. But Chu et al. failed to make a distinction among a pattern histopathologic (Churg-Strauss granuloma), a lesion clini…

Histologic Diagnosis of Inflammatory Skin Diseases

Algorithms Predicated on “Nonspecific” Findings

…gen (late), and a perivascular lymphoplasmacytic infiltrate = Necrobiosis lipoidica + Histiocytes, some of them at times with evidence of elastophagocytosis, in company with a sparse infiltrate of lymphocytes in interstitial array in foci = Mycosis…

Histologic Diagnosis of Inflammatory Skin Diseases

Study By Disease

…ides, plaque and patch stages (Quiz #632) Myiasis (Quiz #604) Necrobiosis lipoidica (Quiz #184) Necrobiosis lipoidica (Quiz #185) Necrobiosis lipoidica (Quiz #262) Necrobiosis lipoidica (Quiz #301) Necrobiosis lipoidica (Quiz #490) Necrobiosis lipoid…

Differential Diagnosis in Dermatopathology

Xanthogranuloma vs. Necrobiotic xanthogranuloma

A granulomatous inflammatory process characterized clinically by patches that become yellowish plaques and that in time resolve with atrophy and telangiectases. The condition usually occurs in persons with diabetes….

Dermatology Practical & Conceptual

Actinic granuloma

…of numerous multinucleated giant cells. There was no area of necrobiosis. Verhoeff van Gieson stained sections revealed loss of elastic fiber in the center but the presence of fragments of elastin within the giant cells (Figure 2). Alcian blue stain…

Histologic Diagnosis of Inflammatory Skin Diseases

Miescher’s granuloma of the face

…in conjunction with histiocytes and it lacks asteroid bodies. Necrobiosis lipoidica is accompanied by prominent degeneration of collagen that eventually is followed by thickened bundles of collagen and is not associated with asteroid bodies, the proc…

Differential Diagnosis in Dermatopathology

Discussions

…iritis, and keratitis. On extremities, a lesion may resemble necrobiosis lipoidica closely. When a diagnosis of necrobiotic xanthogranuloma has been established on grounds histopathologic, search must be undertaken for evidence of associated parapro…