Search Results for: necrobiosis

Histologic Diagnosis of Inflammatory Skin Diseases

Confusing Terms (to be Avoided Scrupulously)

…d with various palisaded granulomatous inflammations of the skin and subcutaneous fat. Diverse diseases purported to display necrobiosis are granuloma annulare, necrobiosis lipoidica, necrobiotic xanthogranuloma, and rheumatoid nodule. The…

Differential Diagnosis in Dermatopathology

Discussions

…emonstrable in the center of palisaded granulomas and in zones where histiocytes are splayed in the interstitium, whereas in necrobiosis lipoidica none of it is detectable anywhere. In a very early lesion of granuloma annulare and of necrobiosis

Histologic Diagnosis of Inflammatory Skin Diseases

Necrobiotic xanthogranuloma

…s of unquestionable fat necrosis in the form of foam cells and cholesterol clefts, whereas the latter are not encountered in necrobiosis lipoidica. Moreover, the panniculitis in necrobiosis lipoidica is confined largely to septa affecting lobules…

Histologic Diagnosis of Inflammatory Skin Diseases

Limitations of the Algorithmic Method

…is being all that now is awry (see Fig. 5.139) or of fibroplasia absent any hint of granulomatous inflammation at the end of necrobiosis lipoidica. Melanophages when a sign of postinflammatory pigmentary alteration are not, in themselves, indicative…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…erol clefts, mononuclear foam cells, and multinucleate Touton giant cells being findings expected in the disease, but not in necrobiosis lipoidica. 10.68.4A: Perivascular and interstitial dermatitis, and panniculitis, lobular + 10.68.4B:…

Histologic Diagnosis of Inflammatory Skin Diseases

Cells That Mediate Inflammation (Inflammatory Cells)

…e death of tissue simultaneous with replacement of it by what they considered to be viable tissue. We eschew the term “necrobiosis” because it is so imprecise and thereby impedes communication. Moreover, it is completely unnecessary. The…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Churg-Strauss Granuloma and Allergic Granulomatosis?

…a annulare—like histology in the spectrum of vasculitis. Eur J Dermatol 1993;3:175–79. “Extravascular granuloma: Focal necrobiosis with peripheral palisading histiocytic granuloma was the prominent feature in three patients. The findings of a…

Histologic Diagnosis of Inflammatory Skin Diseases

Algorithms Predicated on “Nonspecific” Findings

…with arthritis + Degenerated collagen in the center of palisades (early) and crowded, thickened bundles of collagen (late) = Necrobiosis lipoidica + Extensive degeneration of collagen, cholesterol clefts, and necrotic inflammatory cells in the…

Histologic Diagnosis of Inflammatory Skin Diseases

Study By Disease

…que (Quiz #558) Mycosis fungoides, plaque and patch stages (Quiz #632) Myiasis (Quiz #604) Necrobiosis lipoidica (Quiz #184) Necrobiosis lipoidica (Quiz #185) Necrobiosis lipoidica (Quiz #262) Necrobiosis lipoidica (Quiz #301) Necrobiosis lipoidica…