Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Necrotizing Vasculitis?

…which the fully developed stage is characterized by fibrinoid necrosis and inflammation involving all three layers of vessel walls. Five distinct types of lesions of this nature are now recognized and can be differentiated morphologically and clinica…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…tes in association with scattered lymphocytes = Traumatic fat necrosis ┬áThe granulomatous lobular panniculitis and fibrosing dermatitis are a consequence of a procedure surgical performed at this site. The term “traumatic fat necrosis” is…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Wegener’s Granulomatosis?

“Inside the nose besides extensive necrosis, there is a cell-rich granulomatous tissue with granulomatous epithelioid cell foci which surround the vessels. . . . In both lungs: infarct-like necrosis in which one finds severe changes in the ve…

Histologic Diagnosis of Inflammatory Skin Diseases

Pancreatic panniculitis

…atic panniculitis Synonyms Pancreatitis with subcutaneous fat necrosis Systemic nodular fat necrosis Pancreatic enzyme panniculitis Nodular fat necrosis Weber-Christian syndrome of pancreatic origin Presentation stereotypical Age and sex Fourth to si…

Histologic Diagnosis of Inflammatory Skin Diseases

Atypical mycobacterial infections

…n the dermis and sometimes in lobules in the subcutaneous fat Necrosis of adipocytes in lobules varies from slight to marked Granulomatous inflammation, i.e., epithelioid histiocytes in collections surround zones of suppuration and fat necrosis Moder…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Endothelial Swelling?

…, where it will join still-smoldering terms such as fibrinoid necrosis, necrosis of collagen, and toxic hyaline, and on which should be thrown eczema, parapsoriasis, and dysplasia. The gerund swelling implies progression and denotes an action that ca…

Histologic Diagnosis of Inflammatory Skin Diseases

Hypodermitis sclerodermiformis

…is, but in septa widened considerably in the subcutaneous fat Necrosis of adipocytes of variable extent manifested by foam cells, membranous fat necrosis, and fat “microcysts” in shrunken lobules Lobules in the subcutaneous fat constricte…

Histologic Diagnosis of Inflammatory Skin Diseases

Cold panniculitis

Cold panniculitis Synonyms Adiponecrosis e frigore (Haxthausen) Presentation stereotypical Age and sex Newborns and young children Distribution of lesions Sites exposed to low temperature, such as the face and distal part of the extremities Individu…

Differential Diagnosis in Dermatopathology

Discussions

…e, in lobules and septa, comprised mostly of lymphocytes, fat necrosis with resultant foamy histiocytes, degeneration of collagen in fibrous septa, prominent nuclear “dust” of lymphocytes, and lymphocytes in the wall of medium-sized blood…