Histologic Diagnosis of Inflammatory Skin Diseases

Blood Vessels

…nits) and nonepithelial structures of adnexa (smooth muscles, nerves, and medium-sized and larger blood vessels). Figure 1.72 The dermal vasculature consists of a network of two plexuses that parallel the skin surface. The superficial plexus is si…

Differential Diagnosis in Dermatopathology

Discussions

…everal discrete, hypopigmented anesthetic patches. Peripheral nerves may be thickened palpably in patients with that particular form of the disease. Patients with tuberculoid leprosy are capable of expressing delayed hypersensitivity, whereas those w…

Histologic Diagnosis of Inflammatory Skin Diseases

Confusing Terms (to be Avoided Scrupulously)

…he skin that were thought to be related in some way to “nerves,” either organically or psychologically. Two types of neurodermatitis have been described, namely, circumscribed (lichen simplex chronicus) and disseminated (atopic dermatitis…

Histologic Diagnosis of Inflammatory Skin Diseases

Subcutaneous Fat

…s septa also house muscle-containing vessels, lymphatics, and nerves. (x25) Arteries and veins in the subcutaneous fat are positioned within the major fibrous septa (Figs. 1.87 and 1.88). Smaller vessels that emanate from large blood vessels in septa…

Dermatology Practical & Conceptual

A keratoacanthoma with venous invasion

…metastasising) behaviour [1]. Although invasion of peripheral nerves has been reported [2,5] this has not been associated with an adverse prognosis. One of the authors (DW, data not shown) has now seen 122 cases of KA with perineural invasion without…

Histologic Diagnosis of Inflammatory Skin Diseases

Dermoepithelial Interface

…eccrine units. Moreover, the vasculature and Schwann cells of nerves also are surrounded by a basement membrane. Figure 1.70 Basement membrane zone as seen through a conventional microscope, namely, a band of periodic acid-Schiff (PAS)-positive ne…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Nevus Cells, Nevocytes, and Nevomelanocytes?

…cytes in the lower dermis being derived from Schwann cells of nerves.” Rhodes AR. Neoplasms: benign neoplasias, hyperplasias, and dysplasias of melanocytes. In: Fitzpatrick TB, Eisen AZ, Wolff K, et al., eds. Dermatology in General Medicine. 4…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Trichodiscoma Related to the Hair Disk and Merkel-Cell Neoplasm to Merkel Cells?

…hly vascularized connective tissue and innumerable myelinated nerves, makes contact with Merkel cells that reside in the basal layer of the epidermis. Merkel cells are neuroendocrine ones that are present in human skin. That is not the case, however,…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…y and forcefully, probably because of effects pruritogenic on nerves of enzymes released from neutrophils. Those effects could be the reason for the implacable pruritus associated with suppurative infundibulitis in patients on renal dialysis. 1…