Search Results for: nerves

Histologic Diagnosis of Inflammatory Skin Diseases

Dermoepithelial Interface

…xa, i.e., hair follicles, sebaceous units, apocrine units, and eccrine units. Moreover, the vasculature and Schwann cells of nerves also are surrounded by a basement membrane. Figure 1.70 Basement membrane zone as seen through a conventional…

Histologic Diagnosis of Inflammatory Skin Diseases

Langerhans’ Cells

…epidermis where they seem to touch Langerhans” cells, thereby creating a link between the nervous and immune systems. Nerves, by virtue of release from them of neuropeptides, such as calcitonin gene-related peptide, are able to modulate the…

Histologic Diagnosis of Inflammatory Skin Diseases

Sebaceous Units

…positive, and by a thin, highly vascular zone of periadnexal connective tissue. Sebaceous glands are not innervated by motor nerves. The mite, Demodex folliculorum, is present commonly not only within infundibula, but also within sebaceous ducts of…

Waldenström macroglobulinaemia presenting as tingling ulcers on the feet

Waldenström macroglobulinaemia presenting as tingling ulcers on the feet

…op, develop later. The possible mechanisms in Waldenström macroglobulinaemia include microangiopathy, direct infiltration of nerves, endoneural deposition of IgM protein or amyloidosis, hyperviscosity or immunoglobulin deposit in blood vessels. The…

Dermoscopic findings in a patient with multiple piloleiomyomas

Dermoscopic findings in a patient with multiple piloleiomyomas

…1]. These tumors are painful on exposure to cold and trauma; pain could result from local pressure by the tumor on cutaneous nerves [3]. The main differential diagnosis consists of other dermal nodular lesions like dermatofibroma, eruptive…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Origin of Adnexal Neoplasms?

…gin of adnexal neoplasms, i.e., whether they derive from follicles, sebaceous units, apocrine units, eccrine units, muscles, nerves, or vessels (blood or lymphatic); only the direction of differentiation can be inferred. On the basis of study of…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Trichodiscoma Related to the Hair Disk and Merkel-Cell Neoplasm to Merkel Cells?

…r part of the dermis of mammals. The hair disk, composed of highly vascularized connective tissue and innumerable myelinated nerves, makes contact with Merkel cells that reside in the basal layer of the epidermis. Merkel cells are neuroendocrine…

Histologic Diagnosis of Inflammatory Skin Diseases

Suggested Readings

…MA, Parades B, Ackerman AB. Sites of attachment of the muscle of hair erection. Dermatopathol Pract Concept 1995;1:229-233. Nerves Johnson KO. The roles and functions of cutaneous mechanoreceptors. Curr Opin Neurobiol 2001;11:455-461. Johnson KO,…

Differential Diagnosis in Dermatopathology

Differential Diagnosis

…ined to the dermis, except for tuberous and tendinous types that affect the subcutaneous fat 11. Granular cells in cutaneous nerves 11. No foam cells in cutaneous nerves 12. Little fibrosis 12. Marked fibrosis at times 13. No extracellular lipid 13….