Therapeutic Strategies in Dermatology

Lichen Planus: Treatment

Treatment Localized lichen planus Initial therapy First-line treatment: Superpotent topical steroid ointment or cream. Apply superpotent fluorinated topical steroid ointment or cream such as fluocinonide (such as Lidex), betamethasone (such as Dipro…

A Clinical Atlas of 101 Common Skin Diseases

Drug Eruptions

An inflammatory process that results from the effects of a drug administered systemically, e.g., by ingestion, inhalation, injection, or application rectally, and manifested usually by lesions distributed widely and symmetrically. Any of the many ex…

A Clinical Atlas of 101 Common Skin Diseases

Extramammary Paget’s Disease and Mammary Paget’s Disease

Extramammary Paget’s disease is an apocrine carcinoma that begins within the epidermis and presents itself clinically as a patch or a subtle plaque that extends centrifugally for many years before becoming a readily discernible thick plaque, a…

A Clinical Atlas of 101 Common Skin Diseases

Nummular Dermatitis

An inflammatory process of unknown cause consisting of pruritic coin-shaped lesions of different sizes and made up of vesicles that soon are scratched away, leaving erosions, ulcerations, and crusts as residua….

A Clinical Atlas of 101 Common Skin Diseases

Fixed Drug Eruption

Circular orange-red-blue macule(s) or patch(es) that often becomes a papule(s) or plaque(s) and vesiculates, healing with hyperpigmentation, and that occurs repeatedly at the very same cutaneous and/or mucous membrane site(s), especially the genital…

Histologic Diagnosis of Inflammatory Skin Diseases

Mycosis fungoides

…soid, sometimes arciform, annular, polycyclic, or serpiginous. Patches tend to be ill defined at their periphery and without a characteristic shape. Individual lesions Macules, patches, papules, and plaques, often scaly to varying extent, sometimes t…

Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Perivascular Dermatitis

…oid infiltrate. Wiry bundles of collagen in conjunction with a patchy lichenoid infiltrate of lymphocytes are encountered often in the patch/subtle plaque stage of mycosis fungoides, as shown here, those bundles being a sign of the infiltrate having…

Histologic Diagnosis of Inflammatory Skin Diseases

Applicable Terms

…columns of parakeratosis tilt toward the center of the lesion. PATCH [ME. pache (area distinct from that around it)]: A broad, i.e., more than 1.0 cm, flat lesion. A macule, in contrast to a patch, is a flat lesion less than 1.0 cm in greatest diamet…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…ed mounds of parakeratosis or of scale-crust are seen often in patches and plaques of indubitable mycosis fungoides, such as in the example depicted here. Identical changes in the cornified layer also are encountered in more subtle macules and patche…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Lentigo Maligna?

“Melanoma arising from lentigo maligna is preceded by or forms a part of a recognizable series of events affecting the melanocytic cellular system in a way similar to these stages. First, there is a long period characterized by an increase in…