Therapeutic Strategies in Dermatology

Keratosis Pilaris: Clinical Case

…pules with a central spicule overlying a faintly erythematous patch No pustules present Diagnosis: KP, non-inflammatory Recommendation: mechanical exfoliation with washcloth daily in the shower, followed by daily application of 20% urea cream Gentle…

A Clinical Atlas of 101 Common Skin Diseases

Drug Eruptions

An inflammatory process that results from the effects of a drug administered systemically, e.g., by ingestion, inhalation, injection, or application rectally, and manifested usually by lesions distributed widely and symmetrically. Any of the many ex…

A Clinical Atlas of 101 Common Skin Diseases

Extramammary Paget’s Disease and Mammary Paget’s Disease

…gins within the epidermis and presents itself clinically as a patch or a subtle plaque that extends centrifugally for many years before becoming a readily discernible thick plaque, a finding that signifies involvement by the carcinoma of the dermis,…

A Clinical Atlas of 101 Common Skin Diseases

Fixed Drug Eruption

Circular orange-red-blue macule(s) or patch(es) that often becomes a papule(s) or plaque(s) and vesiculates, healing with hyperpigmentation, and that occurs repeatedly at the very same cutaneous and/or mucous membrane site(s), especially the genital…

A Clinical Atlas of 101 Common Skin Diseases

Nummular Dermatitis

An inflammatory process of unknown cause consisting of pruritic coin-shaped lesions of different sizes and made up of vesicles that soon are scratched away, leaving erosions, ulcerations, and crusts as residua….

Histologic Diagnosis of Inflammatory Skin Diseases

Mycosis fungoides

…lesions Often widespread, but sometimes localized to a single patch or plaque. Involvement of palms and soles occurs episodically, and of mucous membranes rarely. Configuration of lesions Round, oval, and ellipsoid, sometimes arciform, annular, polyc…

Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Perivascular Dermatitis

…panied by extruded red blood cells telegraphs likelihood of a patch of mycosis fungoides (Fig. 5.26 A&B). In the case of Schamberg’s disease, the extrusion of erythrocytes into the dermis follows on compromise of the wall of small vessels s…

Histologic Diagnosis of Inflammatory Skin Diseases

Applicable Terms

…#8220;dust” of lymphocytes is lupus profundus, in which patchy lymphoplasmacytic infiltrates in lobules of the subcutaneous fat are accompanied by nuclear debris of lymphocytes in variable amount. Tingible bodies in germinal centers of some exp…

Histologic Diagnosis of Inflammatory Skin Diseases


…ith scant spongiosis in the spinous zone = Mycosis fungoides, patch  The diagnosis of mycosis fungoides can be made from findings in the epidermis alone, as shown here. Note the absence of any collections of lymphocytes there; Pautrier’s &#8220…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Lentigo Maligna?

…as founded by him, was written by him), who first described a patch of pigmentation on the face, the eyelid in particular, which he termed lentigo melanosis. Later in that same journal he referred to the lesion as showing “melanotic staining.&#…