Resolving Quandaries in Dermatology, Pathology & Dermatopathology

-oid?

…ntle of lymphocytes (so-called naked tubercles). Granulomas in sarcoidosis may be tuberculoid, i.e., epithelioid tubercles surrounded by dense infiltrates of lymphocytes, e.g., as in subcutaneous sarcoidosis. Paradoxically, tubercles of tuberculoid l…

Histologic Diagnosis of Inflammatory Skin Diseases

Syphilis

…oriasis is not lichenoid. Secondary syphilis may even resemble sarcoidosis as when epithelioid histiocytes are congregated and surrounded by a sparse infiltrate of lymphocytes and plasma cells. In sarcoidosis, unlike secondary syphilis, there usually…

Histologic Diagnosis of Inflammatory Skin Diseases

Cells That Mediate Inflammation (Inflammatory Cells)

…y, from tuberculoid granulomas. In actuality, some examples of sarcoidosis exhibit dense infiltrates of lymphocytes around collections of epithelioid histiocytes, e.g., some lesions of subcutaneous sarcoidosis, and even display necrosis in the center…

Histologic Diagnosis of Inflammatory Skin Diseases

Erythema nodosum

Erythema nodosum Synonyms Erythema contusiforme Erythema contusiformis Dermatitis contusiformis Erythema nouesux Presentation stereotypical Age and sex Young adults, especially women Distribution of lesions Bilateral and symmetrical over the pretibi…

Histologic Diagnosis of Inflammatory Skin Diseases

Errors and Reasons

Error: Abortive is an accurate modifier of particular pathologic processes, e.g., abortive dermatofibroma, abortive morphea, and abortive T-cell lymphoma. Reason: The idea itself is abortive! For example, what is called “abortive T-cell lympho…

Histologic Diagnosis of Inflammatory Skin Diseases

The Algorithmic Method

An algorithm is a method for calculation based on logical thought and orderly sequence, one that can be utilized for diagnosis of diseases of all kinds, including inflammatory ones of the skin. Once a disorder of the skin and/or subcutaneous fat has…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Endothelial Swelling?

“In PLEVA, the more severe form, one observes vascular changes consisting of a pronounced mononuclear infiltrate around capillaries, with the capillaries showing endothelial swelling and permeation of their walls by the infiltrate. This usua…

Histologic Diagnosis of Inflammatory Skin Diseases

Foreign body reaction

…on is black. Differential diagnosis histopathologic Systemic sarcoidosis may manifest itself at the site of trauma previous and foreign bodies sometimes can be identified in a lesion of sarcoidosis. Infectious processes (deep fungal infection, aty…