Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Basal-Cell Carcinoma Common in Nevus Sebaceus?

Nevus sebaceus may be ‘programmed’ for or susceptible to the eventual development of a variety of neoplasms that generally occur in adulthood. The most common of these is basal cell carcinoma, which develops in 5% to 7% of the l…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Junctional Activity and Active Junctional Nevus?

“With further maturation junctional activity ceases and the lesion is composed only of dermal nevus cells (intradermal nevus).” Weedon D. Lentigines, nevi, and melanomas. In: Skin Pathology. 2nd ed. New York, NY: Churchill-Livingstone,…

Clinical Case Studies

Nevus of Ota

…tions. Skin examination revealed a 3 x 7 cm area of gray coalescing macules in the left infraorbital region. There was no associated change in skin texture. No scleral pigment was noted. Figure 1. Nevus of Ota at patient’s initial presentati…

Differential Diagnosis in Dermatopathology

Verrucous seborrheic keratosis vs. Verrucous epidermal nevus

A malignant neoplasm of melanocytes that, in the skin, begins as a macule and may become a patch or a papule. A flat lesion of melanoma tends to be asymmetrical, poorly circumscribed with a scalloped, jagged, or notched border, and variegate, mostly…

Differential Diagnosis in Dermatopathology

Nevus verrucosus vs. Acanthosis nigricans

A malignant neoplasm of melanocytes that, in the skin, begins as a macule and may become a patch or a papule. A flat lesion of melanoma tends to be asymmetrical, poorly circumscribed with a scalloped, jagged, or notched border, and variegate, mostly…

Differential Diagnosis in Dermatopathology

Morphea, late stage vs. Collagenous nevus

A malignant neoplasm of melanocytes that, in the skin, begins as a macule and may become a patch or a papule. A flat lesion of melanoma tends to be asymmetrical, poorly circumscribed with a scalloped, jagged, or notched border, and variegate, mostly…

Differential Diagnosis in Dermatopathology

Sebaceous hyperplasia vs. Nevus sebaceus of Jadassohn

A malignant neoplasm of melanocytes that, in the skin, begins as a macule and may become a patch or a papule. A flat lesion of melanoma tends to be asymmetrical, poorly circumscribed with a scalloped, jagged, or notched border, and variegate, mostly…