Therapeutic Strategies in Dermatology

Cutaneous T-Cell Lymphoma/ Mycosis Fungoides: Overview

…urface area Stage IIA-patches or plaques < o r> 10% body surface area with palpable lymph nodes without pathologic involvement Stage IIB-tumors with or without palpable lymph nodes in the absence of pathologic involvement Stage III-erythroderma…

Therapeutic Strategies in Dermatology

Melanoma: Treatment

…e necessary to find adjuvant therapies with benefit on overall survival. Clinical trials with vaccination or other immunomodulatory drugs are ongoing in stage III melanoma patients. Chemotherapy and adjuvant radiotherapy might be proposed in certain…

Therapeutic Strategies in Dermatology

Melanoma: Initial Evaluation

…red, purple). Nodular melanoma (NMM): Typically presents as a solitary nodule that arises from a pre-existing nevus or de novo. They may grow rapidly in thickness without radial spread (extension along the surface of the skin). Lentigo maligna melan…

Dermatology Practical & Conceptual

Spitz and Reed nevi: acquired or congenital?

…a survey on clinical, dermatoscopic and histopathologic clues suggesting a congenital origin of authentic Spitz nevi. Relevant differences in respect to Reed nevi are pointed out. What is a nevus? In classic pathology, the term nevus is usually rela…

Therapeutic Strategies in Dermatology

Melanoma: Principles of Management of Melanoma

…istological, genetic or molecular features, anatomic location, spread to regional lymph nodes, and clinical features may also influence clinical outcome. Clinical staging is predicated on whether the tumor has spread to regional lymph nodes or distan…

Therapeutic Strategies in Dermatology

Papular Urticaria: Treatment

…r papular urticaria is to identify and eliminate the arthropod source and to then suppress the resultant inflammatory reaction. First-line management of the inflammatory reaction involves three basic steps: Treat the patient’s hypersensitivity react…

Dermatology Practical & Conceptual

Melanoma arising in a giant nevus spilus maculosus

Abstract Melanoma arising in a nevus spilus is rare. There are two distinct types of nevus spilus characterized by macular or papular speckles, respectively. We report the case of a melanoma that arose in association with a giant nevus spilus maculo…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Nevus Cells, Nevocytes, and Nevomelanocytes?

“A nevus (mole) is a benign neoplasm of pigment-forming cells, the nevus cell.” Lookingbill DP, Marks JG Jr. Principles of clinical diagnosis. In: Moschella SL, Hurley HJ, eds. Dermatology. 3rd ed. Philadelphia, PA: WB Saunders Co., 19…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Basal-Cell Carcinoma Common in Nevus Sebaceus?

…us-cell carcinoma and basal-cell carcinoma arising in a naevus sebaceous of Jadassohn: case report and literature review. Clin Exp Dermatol 2005 May;30(3):259-60. Virtually every textbook in which an entry about nevus sebaceus is found states that b…