Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Junctional Activity and Active Junctional Nevus?

…onal activity ceases and the lesion is composed only of dermal nevus cells (intradermal nevus).” Weedon D. Lentigines, nevi, and melanomas. In: Skin Pathology. 2nd ed. New York, NY: Churchill-Livingstone, 2002:806. “Intradermal nevi sho…

Differential Diagnosis in Dermatopathology

Verrucous seborrheic keratosis vs. Verrucous epidermal nevus

Papules, nodules, and tumors that, on gross examination, are usually skin colored and, on histopathologic examination, consist of an epithelium-lined sac that contains fluid, cells, or both in the case of true cysts and of cysts that are associated…

Therapeutic Strategies in Dermatology

Melanoma: Initial Evaluation

Initial Evaluation Clinical variants of melanoma: Superficial spreading melanoma (SSM): The most common form of melanoma, and typically presents with irregular borders, highly uneven pigmentation and/or unusual pigmentation (i.e., blue, pink, red,…

Dermatology Practical & Conceptual

Spitz and Reed nevi: acquired or congenital?

…re recognized and, recently, at least blue type nevi, Miescher nevus and Unna nevus have been accepted as congenital type melanocytic nevi [1,4,9,21,47]. In contrast, although conflicting with the concept of nevi being hamartomas, to this day, Spitz

Dermatology Practical & Conceptual

Melanoma arising in a giant nevus spilus maculosus

Abstract Melanoma arising in a nevus spilus is rare. There are two distinct types of nevus spilus characterized by macular or papular speckles, respectively. We report the case of a melanoma that arose in association with a giant nevus spilus maculo…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Nevus Cells, Nevocytes, and Nevomelanocytes?

“A nevus (mole) is a benign neoplasm of pigment-forming cells, the nevus cell.” Lookingbill DP, Marks JG Jr. Principles of clinical diagnosis. In: Moschella SL, Hurley HJ, eds. Dermatology. 3rd ed. Philadelphia, PA: WB Saunders Co., 19…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Basal-Cell Carcinoma Common in Nevus Sebaceus?

…ll carcinoma, rather than trichoblastoma, develops commonly in nevus sebaceus. In fact, just the opposite is the case; basal-cell carcinoma is associated uncommonly with nevus sebaceus, whereas trichoblastoma develops in it not uncommonly. Difference…

Histologic Diagnosis of Inflammatory Skin Diseases

Lichen planus-like keratosis

Lichen planus-like keratosis Presentation stereotypical Age and sex Older individuals bombarded by rays of the sun for many years Distribution of lesions Sun-exposed sites, especially the chest and shoulders Configuration of lesions Round Individual…