Histologic Diagnosis of Inflammatory Skin Diseases

Pityriasis alba

…ymphocytes scattered in the spinous zone in company with scant spongiosis. The spongiosis in both pityriasis alba and in flat lesions of mycosis fungoides does not eventuate in vesiculation. Differentiation between the two disorders, so very differen…

Histologic Diagnosis of Inflammatory Skin Diseases

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…as a consequence of ballooning of keratocytes, rather than of spongiosis. 10.32.4A: Vesicular dermatitis, subepidermal, lymphocytes predominant + 10.32.4B: Vacuolar alteration in company with lymphocytes along the dermoepidermal junction,…

Histologic Diagnosis of Inflammatory Skin Diseases

Photoallergic dermatitis

…lymphocytes mostly Uneven psoriasiform acanthosis Slight focal spongiosis Scale-crusts Correlation clinicopathologic Papules consist of perivascular infiltrates of inflammatory cells, edema of the papillary dermis, and foci of spongiosis; blisters a…

Histologic Diagnosis of Inflammatory Skin Diseases

Limitations of the Algorithmic Method

…on, the pattern is “interface dermatitis,” and the spongiosis and/or ballooning is understood to be a finding additional and expected. It should be recognized, too, that slight spongiosis mediated by a few lymphocytes is anticipated in an…

Histologic Diagnosis of Inflammatory Skin Diseases

Errors and Reasons

…dyce disease, which, like eccrine miliaria, is affiliated with spongiosis in acrosyringia, but in the case of so-called apocrine miliaria, spongiosis occurs in infundibular epidermis, whereas in miliaria rubra it appears in surface epidermis; Fox-For…

Histologic Diagnosis of Inflammatory Skin Diseases

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…lar dermatitis, and an “id” reaction, by virtue of spongiosis only. The situation here is different, namely, in addition to the predominant spongiosis, there also is ballooning which eventuated in necrosis of the epidermis in foci….

Histologic Diagnosis of Inflammatory Skin Diseases

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…yer and houses numerous acantholytic cells without any sign of spongiosis, there are instances in which the dominant findings are of spongiosis and spongiotic vesicles, as is the situation here. The clue to the diagnosis of pemphigus is incipient aca…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…pidermal came into being by virtue of extensive ballooning and spongiosis. Spongiosis is dominant in the lower part of the epidermis and ballooning in the mid and upper parts, in the latter being so severe that necrosis of keratocytes became inevitab…