Histologic Diagnosis of Inflammatory Skin Diseases

Pityriasis alba

…uperficial perivascular infiltrate of lymphocytes Very slight spongiosis in foci; lymphocytes in those foci Slight focal parakeratosis Correlation clinicopathologic The scale consists of parakeratosis and the white appearance presumably results from…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…es, ballooned and individual necrotic keratocytes, and slight spongiosis = Erythema multiforme The normal cornified layer with its basket-weave pattern is an indication that this lesion began just in the past few days. As a rule, there are few, if an…

Histologic Diagnosis of Inflammatory Skin Diseases

Photoallergic dermatitis

…s mostly Little, if any, edema of the papillary dermis Slight spongiosis accompanied by lymphocytes Normal cornified layer Fully developed Superficial, and often deep, perivascular infiltrate; eosinophils, in variable number, in association with ly…

Histologic Diagnosis of Inflammatory Skin Diseases

Limitations of the Algorithmic Method

…s in foci of the spinous zone in association with scant or no spongiosis. When those findings are noted, especially in the context of elongated mounds of parakeratosis, the diagnosis is mycosis fungoides, a lymphoma. For another example, some blister…

Histologic Diagnosis of Inflammatory Skin Diseases

Errors and Reasons

…yce disease, which, like eccrine miliaria, is affiliated with spongiosis in acrosyringia, but in the case of so-called apocrine miliaria, spongiosis occurs in infundibular epidermis, whereas in miliaria rubra it appears in surface epidermis; Fox-Ford…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…a thickened papillary dermis, edema of the papillary dermis, spongiosis verging on vesiculation beneath compact orthokeratosis and foci of scale-crust = Nummular dermatitis on which lichen simplex chronicus has been imposed ┬áThe spongiotic psoriasif…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…An exception is the urticarial manifestation of the disease; spongiosis in that circumstance is accompanied by eosinophils or neutrophils, the latter being pictured here. These findings shown are prior to development of acantholysis. 10.77.2A:…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…idermal came into being by virtue of extensive ballooning and spongiosis. Spongiosis is dominant in the lower part of the epidermis and ballooning in the mid and upper parts, in the latter being so severe that necrosis of keratocytes became inevitabl…