Therapeutic Strategies in Dermatology

Lupus: Key Points

the presence of bullous lesions clinically and histologically, the infiltrate of which may be comprised of neutrophils rather than lymphocytes. Lupus profundus has less epidermal and interface involvement, with the focus of inflammation in the subcut

Differential Diagnosis in Dermatopathology

Lupus erythematosus profundus vs. Panniculitis-like T-cell lymphoma

…e usually occurs as a solitary, rapidly growing tumor. Most of the neoplastic lymphocytes express the CD30 antigen. Panniculitis-like T-cell lymphoma is a distinct type derived from activated cytotoxic T-cells and characterized by plaques and subcuta…

Differential Diagnosis in Dermatopathology

"Pseudolymphoma," B-cell type vs. Malignant lymphoma, B-cell type

…e usually occurs as a solitary, rapidly growing tumor. Most of the neoplastic lymphocytes express the CD30 antigen. Panniculitis-like T-cell lymphoma is a distinct type derived from activated cytotoxic T-cells and characterized by plaques and subcuta…

Therapeutic Strategies in Dermatology

Psoriasis: Principles of Psoriasis Management

…patients achieve 75% reduction in PASI score at 12 weeks, and this improvement is maintained at 24 weeks. Adalimumab (Humira): Recombinant, humanized IgG against TNF-A. It is given as a subcutaneous injection weekly or every other week. Approxima…

Therapeutic Strategies in Dermatology

Melanoma: Principles of Management of Melanoma

…II Invasion of papillary dermis only without involvement of the papillary-reticular dermal interface III Invasion to the papillary dermis without extension into the reticular dermis IV Invasion into the reticular dermis without involvement of…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Cutaneous T-cell Lymphoma?

…hology. 2nd ed. New York, NY: Raven Press, 1994:94. Cutaneous T-cell lymphoma (CTCL), also known as mycosis fungoides, consists of malignant cells that resemble mature T cells. Vargo N. Cutaneous malignancies: KA, CTCL, and KS. Dermatol Nurs. 2006;…

Therapeutic Strategies in Dermatology

Photosensitivity Dermatoses: Overview

…-protected areas; lose its seasonal variation; occur even when the inducing photosensitizer has been stopped; and have a broader wavelength of reactivity. This end stage may also demonstrate histologic features resembling cutaneous T cell lymphoma (s…

Histologic Diagnosis of Inflammatory Skin Diseases

Adult T-cell leukemia/Lymphoma

…ungoides alone, but which actually includes a constellation of T-cell lymphomas, among them also being lymphomatoid papulosis, anaplastic T-cell lymphoma, some examples of Hodgkin’s disease, and so-called subcutaneous panniculitis-like T-cell l…