Search Results for: systematized darier\'s disease

Therapeutic Strategies in Dermatology

Histiocytosis X/Langerhans Cell Histiocytoses: Overview

Overview Langerhans cell histiocytoses (Class I histiocytosis) are a group of disorders most common in childhood due to the accumulation or proliferation of a clonal population of cells bearing the phenotype of a Langerhans cell that has been…

Therapeutic Strategies in Dermatology

Darier’s Disease: Key Points

…ant inheritance causing abnormalities of keratinization stemming from defects in calcium regulation in keratinocytes. The classic skin manifestation is an eruption of hyperkeratotic papules, typically in a seborrheic distribution. Characteristic…

Therapeutic Strategies in Dermatology

Darier’s Disease: References

References Abe M, Inoue C, Yokoyama Y, Ishikawa O. (2011). Successful treatment of Dariers disease with adapalene gel, Ped Derm, 28:197-198. Frezzini C, Cedro M, Leao JC, Porter S. (2006). Darier disease affecting the gingival and oral mucosal…

Therapeutic Strategies in Dermatology

Hailey-Hailey Disease: Key Points

…tly inherited genodermatosis caused by dysregulation of calcium hemostasis in the keratinocyte that leads to acantholysis (loss of cell-cell adhesion) in the epidermis. Clinically, it manifests with macerated, eroded plaques primarily in the…

Therapeutic Strategies in Dermatology

Darier’s Disease: Clinical Case

s on the neck, upper chest Strong family history of Dariers disease Review of systems is notable only for recent fevers in association with worsening rash Presents for management of increasing erythema, crusting on the retroauricular neck, trunk,…

Therapeutic Strategies in Dermatology

Urticaria Pigmentosa / Mastocytosis: Key Points

…occur at any age, and may involve the skin, or affect internal organs including the bone marrow and liver/spleen/lymphatic tissues Urticaria pigmentosa is a form of cutaneous mastocytosis most common in childhood, characterized by brown papules,…

Therapeutic Strategies in Dermatology

Candidiasis: Key Points

…ogenital mucosal sites. Predisposing factors include obesity, diabetes, antibiotic or corticosteroid treatments, immunosuppression, removable prostheses, and chronic or frequent exposure to moisture including saliva, fecal and urinary incontinence….

Therapeutic Strategies in Dermatology

Aphthous Ulcers (Recurrent Aphthous Stomatitis, Canker Sore): Key Points

Key Points Recurrent aphthous ulcers are the most common oral ulcerative ailment, which classically appear as shallow, round or oval ulcers with an inflammatory edge and a faint pseudomembrane. Diagnosis may be made by history and physical exam…

Therapeutic Strategies in Dermatology

Grover’s Disease / Transient Acantholytic Dermatosis: Treatment

Treatment First-line therapy: The first-line therapy for Grover’s is to suppress pruritus and when possible, reduce inflammation and clear lesions. First steps If TAD is not pruritic, treatment may not be required. A high-potency or superpotent…