Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Id Reactions?

“Tuberculides—Since my suggestion in 1896 a number of apparently very dissimilar dermatoses have been grouped under this heading, whose relations with tuberculosis are proved by the following features. . . . The tuberculides themselves…

Histologic Diagnosis of Inflammatory Skin Diseases

Nodular vasculitis

…aboratory confirmation Assessment for any evidence of systemic tuberculosis is indicated. Polymerase chain reaction is useful in an effort to demonstrate Mycobacterium tuberculosis in the lesion itself. Cause and mechanism Both are unknown. Comment N…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 10.94.1A: Infundibulitis, spongiotic, and peri-infundibulitis, granulomatous + 10.94.1B: Lymphocytes and plasma cells around collections of epithelioid histiocytes = Rosacea, papular ┬áSpongiosis in an infundibulum is a finding comm…

Histologic Diagnosis of Inflammatory Skin Diseases

Leprosy

…o-like structures that riddle organs infected by Mycobacterium tuberculosis. The equivalent histopathologic of tubercles in tuberculosis is collections of histiocytes with plump oval nuclei and abundant pale-pink cytoplasm. Because those histiocytes…

Dermatology Practical & Conceptual

Predicting outcome: a fourfold delusion!

…esent disease. For example the identification of Mycobacterium tuberculosis in sputum implies a certainty: the patient has tuberculosis. All to the contrary, prognosis is a statistical computation of what might occur in the future. By its very nature…

Histologic Diagnosis of Inflammatory Skin Diseases

Cells That Mediate Inflammation (Inflammatory Cells)

…n cell-mediated immunity is operative maximally. Mycobacterium tuberculosis typically elicits that distinctive pattern of granulomatous inflammation in tuberculosis. Attempts by host defenses to destroy mycobacteria lead to mobilization and predomina…

Histologic Diagnosis of Inflammatory Skin Diseases

Applicable Terms

ABSCESS [L. abscessus (a going away)]: Clinically, a circumscribed collection of pus and histopathologically a localized collection of neutrophils. An abscess may form in the epidermis, both surface and infundibular, eccrine ducts, dermis, and subcu…