Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Vesicular Dermatitis

…e latter being infection by herpesvirus (simplex, zoster, and varicella), Coxsackie (hand-foot-mouth disease), and parapoxvirus (farmyard pox, i.e., orf and milker’s nodule). Monkey pox produces changes in the epidermis nearly identical to thos…

Histologic Diagnosis of Inflammatory Skin Diseases

Errors and Reasons

…commonly in such disparate conditions as atrophie blanche and varicella; moreover, Degos” disease is not specific unto itself, but rather is a pattern morphologic, the most common representative of which is lupus erythematosus (which, in turn,…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…ess of whether a lesion is that of herpes simplex, zoster, or varicella. 10.47.6A: Vesicular dermatitis, intraepidermal and subepidermal + 10.47.6B: Numerous ghosts of acantholytic multinucleate keratocytes = Infection by herpesvirus, late…

Histologic Diagnosis of Inflammatory Skin Diseases

Applicable Terms

…ed often, as evidenced by tense vesicles that are standard in varicella, miliaria crsytallina, and an “id” reaction. Moreover, a subepidermal blister may be flaccid, as in that severe expression of erythema multiforme, termed badly &#8220…

Histologic Diagnosis of Inflammatory Skin Diseases

Atopic dermatitis

…tis does not erupt (“break out”) in the manner of varicella, lichen planus, or psoriasis; it comes to be in response to pruritus by a person who is atopic (it is “rubbed out” and “scratched out”). There is no doubt…

Histologic Diagnosis of Inflammatory Skin Diseases

Degos’ disease (malignant atrophic papulosis)

…eous rim that is unaffiliated with telangiectases. Scars from varicella are depressed in the center and hypopigmented, but are not encircled by a rim made up, in part, of telangiectases. Lesions of classic chronic discoid lupus erythematosus, at time…