Histologic Diagnosis of Inflammatory Skin Diseases

Alopecia areata, totalis, universalis

…and because of the association at times of alopecia areata and vitiligo, it has been postulated by some students of the subject that cell-mediated immunity is the mechanism responsible for the condition. Vitiligo is thought to be brought into being b…

Histologic Diagnosis of Inflammatory Skin Diseases

Limitations of the Algorithmic Method

The algorithmic method proposed in these pages and predicated on patterns histopathologic is intended to be more than just a guide to diagnosis of particular pathologic processes in skin and subcutaneous fat; it is meant to serve as a springboard fo…

Dermatology Practical & Conceptual

Regression of nevi in a melanoma patient treated with interferon

Background High-risk melanoma patients are occasionally offered adjuvant treatment with interferon alpha 2b as a postsurgical treatment. This treatment is thought to improve disease-free survival by upgrading immunomodulatory functions, which cause…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Focus of Infection?

“. . . we are justified in arranging, provisionally at least, the dermatoses possibly due to focal infection in six groups, as follows: Group 1: Those considered in some relation with arthropathy:            1, erythema nodosum; 2, erythema…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Colors Stereotypical for Diseases Specific?

“The color of skin lesions varies as already stated. … White lesions are rare excepting in exfoliative diseases, the scales of which are white. They usually result from loss of pigment. White spot disease, morphea, some of the idiopathi…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Langerhans’ Cell Granulomatosis?

“The cells of histiocytosis X [HX] have been designated “histiocytes” but the “ordinary” histiocytes encountered in healthy skin, in histiocytoma or various granulomatous processes are devoid of the granules. It could…

Differential Diagnosis in Dermatopathology


Alopecia areata and trichotillomania have several attributes histopathologic in common, namely, some follicles in catagen and often in telogen, long fibrous tracks behind shortened follicles and, in sections from some specimens, and hardly any periv…

Differential Diagnosis in Dermatopathology

Alopecia areata vs. Trichotillomania

An inflammatory process that is idiopathic and results in depigmentation of the skin consequent to loss of melanocytes from the epidermis, and in whitening of hair that follows loss of melanocytes from the bulb of follicles….