Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Perivascular Dermatitis

…language used in the usual discourse of dermatologists, e.g., vitiligo, Schamberg’s disease, and urticaria. Realistically, however, there are, without doubt, situations in which a specific diagnosis simply cannot be made, e.g., a “perivas…

Histologic Diagnosis of Inflammatory Skin Diseases

Alopecia areata, totalis, universalis

…nd because of the association at times of alopecia areata and vitiligo, it has been postulated by some students of the subject that cell-mediated immunity is the mechanism responsible for the condition. Vitiligo is thought to be brought into being by…

Histologic Diagnosis of Inflammatory Skin Diseases

Limitations of the Algorithmic Method

…rm drug eruption, indeterminate leprosy, or an early stage of vitiligo. In such a circumstance, the diagnosis histopathologic given must be descriptive, namely, “perivascular dermatitis, lymphocytic, superficial, sparse,” to which a note…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Langerhans’ Cell Granulomatosis?

…k et al. found by use of electron microscopy in patients with vitiligo, pentalaminar organelles in the cytoplasm of epidermal Langerhans’ cells (J Invest Dermatol 37:51). In 1965 Basset reported on a peculiar organelle that he saw through an el…

Dermatology Practical & Conceptual

Regression of nevi in a melanoma patient treated with interferon

…:30-75. 5. Byrne KT, Turk MJ. New perspectives on the role of vitiligo in immune responses to melanoma. Oncotarget. 2011;2(9):684-94. 6. Zeff RA, Freitag A, Grin CM, Grant-Kels JM. The immune response in halo nevi. J Am Acad Dermatol. 1997;37(4):62…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Focus of Infection?

…pecia areata; 7, dermatitis herpetiformis; 8, scleroderma; 9, vitiligo. Group 3: Those considered in some relation with tuberculosis:            1, erythema induratum; 2, lupus erythematosus; 3, lupus vulgaris; 4, lichen scrofulosorum; 5, various tub…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Colors Stereotypical for Diseases Specific?

…hea, some of the idiopathic atrophies, syphilitic leucoderma, vitiligo, the peculiar whitish blue of argyria, and depigmented scars are examples. Psoriasis scales have a peculiar silvery tinge. Pink and red lesions are usually inflammatory, excepting…