Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Eosinophilic Cellulitis (Wells’ Syndrome)?

…es. Apart from blood eosinophilia, the patients had no notable systemic signs or symptoms. In 1979, Spigel and Winkelmann introduced the eponym Wellssyndrome in their account of two patients. The lesions in their patients seemed to be related…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Follicular Degeneration Syndrome?

“An irreversible alopecia of the scalp occurs in negro women who straighten their hair with hot combs. The disease is common and distinctive, clinically and histopathologically. . . . Hot petrolatum used with the comb causes a chronic inflamm…

Histologic Diagnosis of Inflammatory Skin Diseases

Toxic shock syndrome

Toxic shock syndrome Synonyms TSS Presentation stereotypical Age and sex Women using super-absorbent vaginal tampons especially, but possible in both sexes consequent to any infection by pathogenic bacteria, particularly Staphylococcus aureus, inclu…

Histologic Diagnosis of Inflammatory Skin Diseases

Sweet’s syndrome

Sweet’s syndrome Synonyms Acute febrile neutrophilic dermatosis Presentation stereotypical Age and sex Middle-aged persons, more often women than men Distribution of lesions Upper and lower extremities, neck, and face. Sometimes limited to dor…

Differential Diagnosis in Dermatopathology

Erythema multiforme vs. Toxic shock syndrome

…by markedly edematous acuminate papules and edematous plaques situated mostly on the face, upper part of the trunk, and arms, especially the hands, and often accompanied by fever and leukocytosis. It may be idiopathic or a manifestation of a systemi…

Histologic Diagnosis of Inflammatory Skin Diseases

Acroangiodermatitis of Mali/Stewart-Bluefarb syndrome

Acroangiodermatitis of Mali/Stewart-Bluefarb syndrome Presentation stereotypical Age and sex Adults of both sexes Distribution of lesions Localized to the lower part of the legs bilaterally, especially the toes Arrangement of lesions Discrete Indivi…

Histologic Diagnosis of Inflammatory Skin Diseases

Staphylococcal scalded skin syndrome

…by markedly edematous acuminate papules and edematous plaques situated mostly on the face, upper part of the trunk, and arms, especially the hands, and often accompanied by fever and leukocytosis. It may be idiopathic or a manifestation of a systemi…