Histologic Diagnosis of Inflammatory Skin Diseases

Cells That Mediate Inflammation (Inflammatory Cells)

Neutrophils, eosinophils, lymphocytes, plasma cells, and histiocytes are called inflammatory cells because they enter tissue during the process of inflammation. A more exact designation for them is “cells of an inflammatory process”; the…

Dermatology Practical & Conceptual

From the Dermatologikum Hamburg: Quiz

…The deposits are brightly PAS positive (periodic acid-Schiff, x20). The eccrine units, however, are spared and only the vessel walls are thickened (periodic acid-Schiff, x200). Figure 4A and B. Immunostain for type IV collagen highlights the depo…

Histologic Diagnosis of Inflammatory Skin Diseases

Grover’s disease

Grover’s disease Synonyms Transient acantholytic dermatosis Transitory acantholytic dermatosis Benign papular acantholytic dermatosis Persistent acantholytic dermatosis Presentation stereotypical Age and sex Middle-aged and elderly adults, h…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Reactive Perforating Collagenosis?

“A case is presented exhibiting an unusual reaction of the skin to superficial trauma. In response to minor trauma, certain changes take place within the papillary layer of the corium characterized by affinity of the connective tissue for he…

Histologic Diagnosis of Inflammatory Skin Diseases

Nerves

Both somatic sensory and autonomic motor nerves are present in skin (Fig. 1.82). The somatic sensory system mediates sensations of pain, itch, temperature, light touch, discriminative touch, pressure, vibration, and proprioception. Nerves of the aut…

Histologic Diagnosis of Inflammatory Skin Diseases

Ground Substance

Ground substance (extrafibrillar matrix) is finely granular extracellular material that enmeshes fibrillar and cellular components of the body, including those of the dermis, binds water, and provides hydration to the skin. The ground substance of n…

Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Fibrosing Dermatitis

See Fig. 5.350 A&B. Figure 5.350 Fibrosing dermatitis. A. Early. B. Late (sclerosis). Fibrosing dermatitis (as well as fibrosing peri-infundibulitis/perifolliculitis and fibrosing panniculitis) results, in every instance, from injury to nonep…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Acquired Epidermolysis Bullosa?

“The “typical” or “average” case of epidermolysis bullosa acquisita may not exist or is at least poorly defined due to the small number of cases accepted as authentic epidermolysis bullosa acquisita.” Woodley DT…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Atopic Dermatitis?

“In America, some of the designations employed [for atopic dermatitis] are: ‘pruritus with lichenification,’ ‘allergic eczema,’ ‘atopic eczema,’ ‘hay fever eczema,’ ‘flexural eczema,&#821…

Histologic Diagnosis of Inflammatory Skin Diseases

Elastic Fibers

Elastic fibers are synthesized by fibrocytes (Fig. 1.80), those fibers imparting to skin the property of returning to its original shape after the effects of forces that deform it. The fibers are capable of extension to approximately twice their len…