Histologic Diagnosis of Inflammatory Skin Diseases

Necrobiosis lipoidica

…hion in company with neutrophils and eosinophils. Necrobiotic xanthogranuloma is marked by epithelioid and foamy histiocytes arrayed in a palisade around zones of extensive degeneration of collagen and by abundant extracellular deposits of lipid, amo…

Histologic Diagnosis of Inflammatory Skin Diseases

Xanthomas

…ox-Fordyce’s disease. Differential diagnosis clinical Xanthogranuloma, especially in an evolving stage, may be indistinguishable from a xanthoma because it is a kind of xanthoma. Urticaria pigmentosa is typified by Darier’s sign. Findi…

Histologic Diagnosis of Inflammatory Skin Diseases

Confusing Terms (to be Avoided Scrupulously)

…is are granuloma annulare, necrobiosis lipoidica, necrobiotic xanthogranuloma, and rheumatoid nodule. The “necrobiotic” change is mostly mucin in conjunction with degeneration of collagen in granuloma annulare, severe degeneration of coll…

Histologic Diagnosis of Inflammatory Skin Diseases

Urticaria pigmentosa

…icaria pigmentosa. Differential diagnosis clinical Juvenile xanthogranuloma usually presents itself in a child as one or several yellow nodules, but without bullae; Darier’s sign cannot be elicited. Spitz’s nevus, especially in children…

Histologic Diagnosis of Inflammatory Skin Diseases

Algorithms Predicated on “Nonspecific” Findings

…which make up a nodular and diffuse infiltrate = Necrobiotic xanthogranuloma + Histiocytes with scant or no foamy cytoplasm in company with eosinophils, plasma cells, and lymphocytes in a nodular infiltrate (early), foamy histiocytes and Touton ce…

Dermatology Practical & Conceptual

Dermatoscopy: What is your diagnosis?

…uiz The correct answer to the quiz in the April 2012 issue is xanthogranuloma. Please see article 3 of this issue of Dermatology Practical and Conceptual for a detailed description of xanthogranuloma with dermatoscopic/dermatopathologic correlation […

Histologic Diagnosis of Inflammatory Skin Diseases

Applicable Terms

…n conditions as unalike as necrobiosis lipoidica, necrobiotic xanthogranuloma, and severe burns of any cause, and as a consequence of the effects of neutrophils, in large number, on collagen, as occurs in “Churg-Strauss granulomas,” and o…

Histologic Diagnosis of Inflammatory Skin Diseases

Study By Disease

…ica (Quiz #490) Necrobiosis lipoidica (Quiz #491) Necrobiotic xanthogranuloma (Quiz #533) Necrobiotic xanthogranuloma (Quiz #680) Neuroendocrine carcinoma (Quiz #730) Neurofibroma (Quiz #527) Neurofibroma (Quiz #528) Neurofibroma (Quiz #529) Neurofib…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…histiocytes in a papule = Xanthoma  A xanthoma differs from a xanthogranuloma by being made up of a nearly pure population of foamy histiocytes, practically none of which are multinucleate, and by the absence of accompanying lymphocytes, plasma cells…