Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Vesicular Dermatitis

See Fig. 5.239 A-C. Figure 5.239 A-C. Patterns of vesiculation: intraepidermal, subepidermal, and intra- and subepidermal. “Blister” and “vesiculobullous” are terms generic for lesions of the skin that usually are elevated…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 10.47.1A: Perivascular dermatitis, interface, patchy lichenoid + 10.47.1B: Keratocytes with steel-gray nuclei, “margination” of chromatin, ballooned cytoplasm, and multinucleate and necrotic keratocytes = Infection by h…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Erythema Dyschromicum Perstans?

…that follow on the effects of inflammatory cells are noted in zosteriform distribution, a diagnosis of zoster that underwent involution may be inferred. If they are seen in macules that follow lines of cleavage on a trunk, a diagnosis presumptive of…

Histologic Diagnosis of Inflammatory Skin Diseases

Impetigo contagiosa

Impetigo contagiosa Synonyms Impetigo Presentation stereotypical Age and sex Children, particularly of preschool age, but young adults of either sex may be affected Distribution of lesions Exposed parts of the body, especially the face, hands, neck,…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Focus of Infection?

“. . . we are justified in arranging, provisionally at least, the dermatoses possibly due to focal infection in six groups, as follows: Group 1: Those considered in some relation with arthropathy:            1, erythema nodosum; 2, erythema…

Histologic Diagnosis of Inflammatory Skin Diseases

Farmyard pox

Farmyard pox Synonyms Barnyard pox Presentation stereotypical Age and sex No predilection for age, but more common among men who are herders of sheep (orf) and cows (milker’s nodule), and in veterinarians Distribution of lesions Fingers especi…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Lymphocytic Vasculitis?

“Lymphocytic vasculitis can be inferred unequivocally if there are infiltrates of lymphocytes in and around the walls of venules accompanied by fibrin deposition in their walls or lumens, or both.” Carlson JA, Mihm MC, Leboit PE. Cutan…

Histologic Diagnosis of Inflammatory Skin Diseases

Mucha-Habermann disease

Mucha-Habermann disease Synonyms Pityriasis lichenoides Presentation stereotypical Age and sex Children and young adults especially; more common in males Distribution of lesions Widespread, particularly arms, legs, trunk, and buttocks Arrangement of…

Histologic Diagnosis of Inflammatory Skin Diseases

Granuloma annulare

Granuloma annulare Presentation stereotypical Age and sex Any age in both sexes Distribution of lesions Localized, often to extensor aspects of extremities, or widespread Configuration of lesions Annular, sometimes arcuate Arrangement of lesions Sca…

Histologic Diagnosis of Inflammatory Skin Diseases

Leukocytoclastic vasculitis

Leukocytoclastic vasculitis Synonyms Leukocytoclastic angiitis Allergic vasculitis Hypersensitivity angiitis Hypersensitivity vasculitis Anaphylactoid purpura Immune complex vasculitis Purpura rheumatica Presentation stereotypical Age and sex Any ag…