Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Vesicular Dermatitis

…amples of the latter being infection by herpesvirus (simplex, zoster, and varicella), Coxsackie (hand-foot-mouth disease), and parapoxvirus (farmyard pox, i.e., orf and milker’s nodule). Monkey pox produces changes in the epidermis nearly ident…

Histologic Diagnosis of Inflammatory Skin Diseases

Errors and Reasons

…s is evident, too, in other nonvasculitic conditions, such as zoster. Error: “Necrosis” of collagen, “necrosis” of the wall of small blood vessels, and “necrosis” of other nonviable structures are concepts tenable…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…ame regardless of whether a lesion is that of herpes simplex, zoster, or varicella. 10.47.6A: Vesicular dermatitis, intraepidermal and subepidermal + 10.47.6B: Numerous ghosts of acantholytic multinucleate keratocytes = Infection by herpesv…

Histologic Diagnosis of Inflammatory Skin Diseases

Impetigo contagiosa

…tions to this maxim. For example, vesicles of herpes simplex, zoster, and varicella, as well as those of miliaria crystallina, dyshidrotic dermatitis, and hand-foot-and-mouth disease are tense, yet they are intraepidermal. Severe erythema multiforme,…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Erythema Dyschromicum Perstans?

…that follow on the effects of inflammatory cells are noted in zosteriform distribution, a diagnosis of zoster that underwent involution may be inferred. If they are seen in macules that follow lines of cleavage on a trunk, a diagnosis presumptive of…

Histologic Diagnosis of Inflammatory Skin Diseases

Farmyard pox

…ron microscopic and virologic. Herpes simplex, varicella, and zoster are characterized by marked ballooning, reticular alteration, and intraepidermal vesicles, but those changes are joined by acantholytic cells, multinucleate epithelial giant cells,…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Focus of Infection?

…anus; 2, lichen simplex (Vidal); 3, herpes simplex; 4, herpes zoster; 5, eczema (neurotic); 6, alopecia areata; 7, dermatitis herpetiformis; 8, scleroderma; 9, vitiligo. Group 3: Those considered in some relation with tuberculosis:            1, eryt…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Lymphocytic Vasculitis?

…#8221; Uhoda I, Pierard-Franchimont C, Pierard GE. Varicella-zoster virus vasculitis: a case of recurrent varicella without epidermal involvement. Dermatology 2000;200:173–75. “Outside the context of hereditary deficiencies of compleme…

Histologic Diagnosis of Inflammatory Skin Diseases

Mucha-Habermann disease

…l 1988;10:189–96. Boralevi F, Cotto E, Baysse L. Is varicella-zoster virus involved in the etiopathology of pityriasis lichenoides? J Invest Dermatol 2003;121(3):647–48. Brazzini B, Ghersetich I, Urso C, et al. Pityriasis lichenoides et varioliformis…