Histologic Diagnosis of Inflammatory Skin Diseases

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…looning, intraepidermal vesiculation, or neutrophils in mounds of parakeratosis; in fact, spongiosis in slight and the thickened cornified layer is devoid of inflammatory cells. 10.66.14A: Vesicular dermatitis, ostensibly subepidermal, and peri…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Cytophagic Panniculitis?

“Two cases of what was originally called Weber-Christian disease were found to be a chronic, recurrent form of histiocytic panniculitis characterized by histiocytic engulfment of red and white blood cells—cytophagocytosis. The disease…

Differential Diagnosis in Dermatopathology

Discussions

…s, erythrocytes may be extravasated, a perivascular infiltrate of lymphocytes may be superficial only or superficial and deep, and plasma cells at times may be found among lymphocytes in the upper part of the dermis. Those similarities may be so stri…

Histologic Diagnosis of Inflammatory Skin Diseases

Junctional epidermolysis bullosa

…and erythrocytes. Differential diagnosis histopathologic Other cell-poor subepidermal blistering diseases, such as a suction blister, cell-poor pemphigoid, and one expression of acquired epidermolysis bullosa; all of these “cell poor” bli…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Capillaritis?

…, when developed fully, are characterized by (1) an infiltrate of inflammatory cells and (2) either fibrin in the wall of vessels or thrombi in the lumen of them, or both of those findings together. The papillary dermis and the periadnexal dermis, bo…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Ichthyoses?

“On the basis of clinical, histological, and cellular kinetic observations, a separation of the major ichthyosiform dermatoses into four groups is proposed. Ichthyosis vulgaris patients have dry skin and fine scales on their trunk and extremi…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Pernio, Perniosis, Lupus Pernio, Chilblain, and Chilblain Lupus?

“Eleven out of 17 presented with chilblain LE after the development of facial discoid LE and the delay varied from 1 to 14 years (mean 5.9 years). . . . Three patients had chilblains and bad circulation before the onset of LE. The sites of th…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Discoid Lupus Erythematosus versus Systemic Lupus Erythematosus? II

…with innumerable clinical signs and symptoms and a wide range of laboratory abnormalities; it shows a spectrum of varying prognoses ranging from a benign, solely cutaneous variant (localized discoid) through to a potentially fatal systemic illness.&…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Figurate Erythemas?

…uperficial and deep, mostly perivascular, and usually composed of a mix of cells. If the biopsy specimen comes from near the site of the inciting “bite”, numerous eosinophils are present in the infiltrate. If it comes from the outer margi…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Pseudopelade?

…poid, is characterized by acute folliculitis with inflammation of the dermis in the zone of involvement.” Brocq L. Recherches sur l”alopecie atrophiante, vari?t? pseudopelade [Research about atrophic alopecia, pseudopelade variant]. Ann…