Histologic Diagnosis of Inflammatory Skin Diseases

Images

…tigo contagiosa Only the presence of bacteria in the cytoplasm of some neutrophils enables a diagnosis of impetigo to be made with surety. Otherwise, the findings histopathologic are indistinguishable from those of pemphigus foliaceus, including the…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Pseudopelade?

…poid, is characterized by acute folliculitis with inflammation of the dermis in the zone of involvement.” Brocq L. Recherches sur l”alopecie atrophiante, vari?t? pseudopelade [Research about atrophic alopecia, pseudopelade variant]. Ann…

Histologic Diagnosis of Inflammatory Skin Diseases

Pernio

…nd the infiltrate is superficial only. A particular expression of lupus erythematosus on the hands and feet of young women, usually without discernible edema in the papillary dermis probably is a variant of pernio. Laboratory confirmation None exist…

Histologic Diagnosis of Inflammatory Skin Diseases

Grover’s disease

…pes are: Superficial perivascular and interstitial infiltrate of lymphocytes; eosinophils vary from none to numerous In a 4.0 mm punched out specimen, one focus at least, and usually several, of acantholytic cells, some or all of which are dyskerato…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Cytophagic Panniculitis?

“Two cases of what was originally called Weber-Christian disease were found to be a chronic, recurrent form of histiocytic panniculitis characterized by histiocytic engulfment of red and white blood cells—cytophagocytosis. The disease…

Histologic Diagnosis of Inflammatory Skin Diseases

Junctional epidermolysis bullosa

…and erythrocytes. Differential diagnosis histopathologic Other cell-poor subepidermal blistering diseases, such as a suction blister, cell-poor pemphigoid, and one expression of acquired epidermolysis bullosa; all of these “cell poor” bli…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Capillaritis?

…, when developed fully, are characterized by (1) an infiltrate of inflammatory cells and (2) either fibrin in the wall of vessels or thrombi in the lumen of them, or both of those findings together. The papillary dermis and the periadnexal dermis, bo…

Differential Diagnosis in Dermatopathology

Discussions

…s, erythrocytes may be extravasated, a perivascular infiltrate of lymphocytes may be superficial only or superficial and deep, and plasma cells at times may be found among lymphocytes in the upper part of the dermis. Those similarities may be so stri…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Discoid Lupus Erythematosus versus Systemic Lupus Erythematosus? II

…with innumerable clinical signs and symptoms and a wide range of laboratory abnormalities; it shows a spectrum of varying prognoses ranging from a benign, solely cutaneous variant (localized discoid) through to a potentially fatal systemic illness.&…

Histologic Diagnosis of Inflammatory Skin Diseases

Lymphocytoma cutis

…large pleomorphic nuclei and abundant cytoplasm. Usually, some of those lymphocytes are in mitosis and others are binucleate and multinucleate. In the variant marked by a mix of cells, there may be small lymphocytes, plasma cells, eosinophils, and ne…