Search Results for: clear-cell variant of squamous-cell carcinoma

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Cytophagic Panniculitis?

…culitis, deemed it to be a disease that clinically was confined mostly to the skin; cytopathologically, the neoplastic mononuclear cells exhibited little or no nuclear atypia; and biologically, the disease was benign. Winkelmann called the process…

Differential Diagnosis in Dermatopathology

Discussions

…isualizable; hardly ever are melanophages noted in lichenoid purpura. The lichenoid purpura of Gougerot-Blum is one of three variants histopathologic of persistent purpuric dermatitides, a group of idiopathic, usually asymptomatic, conditions that…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Pernio, Perniosis, Lupus Pernio, Chilblain, and Chilblain Lupus?

…disease. In the other 21 patients, the clinical presentations prompted further studies in 12, which showed a positive antinuclear antibody (ANA) in 10. A diagnosis of idiopathic perniosis (IP) was rendered in all 21 of these patients including…

Histologic Diagnosis of Inflammatory Skin Diseases

Grover’s disease

…usually by smooth or only slightly scaly and/or crusted erythematous papules that result from discrete foci of acantholytic cells in the epidermis and a superficial infiltrate of inflammatory cells. The papillary dermis may be edematous to some…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Necrotizing Vasculitis?

…d synonymously for leukocytoclastic vasculitis. In that vasculitic process, venules themselves are not necrotic. Only living cells can become necrotic and endothelial cells of those venules show no signs of necrosis; they, themselves, do not seem to…

Histologic Diagnosis of Inflammatory Skin Diseases

Leprosy

…tis of small blood vessels is responsible for ulceration of lesions in states deemed to be reactional. The presence of mononuclear cells, particularly histiocytes, in nerve fascicles damages those structures, with resultant alterations in sensation….

Histologic Diagnosis of Inflammatory Skin Diseases

Erythema nodosum leprosum

…of neutrophils and histiocytes in the dermis Fully developed All the findings in early lesions with the addition of a mixed-cell infiltrate of neutrophils, lymphocytes, plasma cells, and histiocytes in fat lobules Late Extensive fibroplasia in the…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Perforating Diseases?

…erforans serpiginosa. There are, in addition, numerous reports of secondary transepidermal elimination in association with a clearly identifiable primary cutaneous process.” Piepkorn MW. Alterations of the stratum corneum and epidermis. In:…