Histologic Diagnosis of Inflammatory Skin Diseases

Hailey-Hailey disease

…as thought by them and by others in the ensuing years to be a variant of pemphigus vulgaris. The reasons for that misinterpretation were the flaccidity of the blisters clinically and the acantholytic cells in the epidermis histopathologically. Despit…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Pernio, Perniosis, Lupus Pernio, Chilblain, and Chilblain Lupus?

…onal microscopy Superficial and deep perivascular infiltrates of lymphocytes Superficial and deep perivascular infiltrates of lymphocytes Laboratory investigation Antinuclear antibody positive Antinuclear antibody positive DIFFERENCES Distrib…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Perforating Diseases?

…n-eosin rather than the usual light blue), neutrophils, and nuclear debris of neutrophils. One thing is certain: the direction of movement of altered elastic fibers is from the dermis to the skin surface, a phenomenon that also has been dubbed &#8220…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Pseudopelade?

…oid, is characterized by acute folliculitis with inflammation of the dermis in the zone of involvement.” Brocq L. Recherches sur l”alopecie atrophiante, vari?t? pseudopelade [Research about atrophic alopecia, pseudopelade variant]. Ann D…

Histologic Diagnosis of Inflammatory Skin Diseases

Pernio

…d the infiltrate is superficial only. A particular expression of lupus erythematosus on the hands and feet of young women, usually without discernible edema in the papillary dermis probably is a variant of pernio. Laboratory confirmation None exists…

Histologic Diagnosis of Inflammatory Skin Diseases

Lymphocytoma cutis

…arge pleomorphic nuclei and abundant cytoplasm. Usually, some of those lymphocytes are in mitosis and others are binucleate and multinucleate. In the variant marked by a mix of cells, there may be small lymphocytes, plasma cells, eosinophils, and neu…

Histologic Diagnosis of Inflammatory Skin Diseases

Leprosy

…onventional polar manifestations and intermediate expressions of leprosy result from dense nodular or diffuse infiltrates of mononuclear inflammatory cells in the reticular dermis and, sometimes, the subcutaneous fat. Histiocytes monopolize in leprom…

Histologic Diagnosis of Inflammatory Skin Diseases

Erythema nodosum leprosum

…ar panniculitis, focal at first and then diffuse Patchy zones of extensive fat necrosis Foam cells scattered in fat lobules In fibrous septa of the subcutaneous fat, fibrin in the wall of some small vessels and thrombi in the lumen of others Sparse i…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Lymphocytic Infiltration of Jessner?

…ys, around vessels and/or appendages. The infiltrates consist of lymphocytes, mostly small ones, and usually a few histiocytes and plasma cells.” Jessner M, Kanof NB, Orfuss AJ. Lymphocytic infiltration of the skin. Arch Dermatol 1953;68:447&#…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Malignant Spitz Nevus?

“A rare malignant variant of the Spitz naevus has been reported which features a higher mitotic rate and subcutaneous invasion. It may metastasize to the regional lymph nodes but not beyond.” Weedon D, Stratton G. Malignant melanoma pa…