Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Necrotizing Vasculitis?

…itic process, venules themselves are not necrotic. Only living cells can become necrotic and endothelial cells of those venules show no signs of necrosis; they, themselves, do not seem to be affected. Collagen in the wall of vessels involved cannot b…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Pseudopelade?

…poid, is characterized by acute folliculitis with inflammation of the dermis in the zone of involvement.” Brocq L. Recherches sur l”alopecie atrophiante, vari?t? pseudopelade [Research about atrophic alopecia, pseudopelade variant]. Ann…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Pernio, Perniosis, Lupus Pernio, Chilblain, and Chilblain Lupus?

“Eleven out of 17 presented with chilblain LE after the development of facial discoid LE and the delay varied from 1 to 14 years (mean 5.9 years). . . . Three patients had chilblains and bad circulation before the onset of LE. The sites of th…

Histologic Diagnosis of Inflammatory Skin Diseases

Pernio

…nd the infiltrate is superficial only. A particular expression of lupus erythematosus on the hands and feet of young women, usually without discernible edema in the papillary dermis probably is a variant of pernio. Laboratory confirmation None exist…

Histologic Diagnosis of Inflammatory Skin Diseases

Lymphocytoma cutis

…large pleomorphic nuclei and abundant cytoplasm. Usually, some of those lymphocytes are in mitosis and others are binucleate and multinucleate. In the variant marked by a mix of cells, there may be small lymphocytes, plasma cells, eosinophils, and ne…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…looning, intraepidermal vesiculation, or neutrophils in mounds of parakeratosis; in fact, spongiosis in slight and the thickened cornified layer is devoid of inflammatory cells. 10.66.14A: Vesicular dermatitis, ostensibly subepidermal, and peri…

Histologic Diagnosis of Inflammatory Skin Diseases

Hailey-Hailey disease

…topathologic Early Sparse superficial perivascular infiltrate of lymphocytes mostly In foci in the lower half of the epidermis, vacuoles present between basal cells and spinous cells and between spinous cells themselves Fully developed Moderately…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Perforating Diseases?

…ating are unrelated to one another. The exact status nosologic of Kyrle’s disease never will be known because Kyrle did not make clear the attributes morphologic or the cause of it. His patients were diabetic. So-called perforating folliculitis…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Malignant Spitz Nevus?

…mitotic rate and mitosis deep within the lesion. There is more cellular pleomorphism, less maturation in depth and less cohesion of cells than in the usual Spitz nevus.” Weedon D, Strutton G. Skin Pathology. 2nd ed. New York: Churchill-Livings…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Lymphocytic Infiltration of Jessner?

…ays, around vessels and/or appendages. The infiltrates consist of lymphocytes, mostly small ones, and usually a few histiocytes and plasma cells.” Jessner M, Kanof NB, Orfuss AJ. Lymphocytic infiltration of the skin. Arch Dermatol 1953;68:447&…