Search Results for: clear-cell variant of squamous-cell carcinoma

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Capillaritis?

…aritis.” Pillsbury DM, Shelley WB, Kligman AM. Diseases of blood vessels. In: Dermatology. Philadelphia, PA: WB Saunders Co, 1956:754. [In “Pigmented purpuric dermatoses”] “It should be emphasized that extravasated red blood c…

Histologic Diagnosis of Inflammatory Skin Diseases

Junctional epidermolysis bullosa

…., above the lamina densa (basal lamina). Vegetations consist of serum admixed with neutrophils and erythrocytes. Differential diagnosis histopathologic Other cell-poor subepidermal blistering diseases, such as a suction blister, cell-poor pemphigoid…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Cytophagic Panniculitis?

…m. The affected tissues are gradually replaced by a syncytium of histiocytic cells with associated T-lymphocytes and plasma cells. The histiocytes are cytophagic so that they become stuffed with white blood cells, red cells, nuclear fragments and pla…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…parse + 10.44.1B: A suprabasal cleft, acanthotic dyskeratotic cells in the spinous and granular zones, and a column of parakeratosis = Grover’s disease Changes in foci of the epidermis identical with those pictured here may be found in Darier&#…

Histologic Diagnosis of Inflammatory Skin Diseases

Grover’s disease

…pes are: Superficial perivascular and interstitial infiltrate of lymphocytes; eosinophils vary from none to numerous In a 4.0 mm punched out specimen, one focus at least, and usually several, of acantholytic cells, some or all of which are dyskeratot…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Necrotizing Vasculitis?

…ts in vasculitis is best illustrated in necrotizing venulitis of the superficial dermal plexus, where fibrillar and amorphous eosinophilic material is deposited within the vessel wall, which is infiltrated by polymorphonuclear leukocytes and becomes…

Histologic Diagnosis of Inflammatory Skin Diseases

Leprosy

…onventional polar manifestations and intermediate expressions of leprosy result from dense nodular or diffuse infiltrates of mononuclear inflammatory cells in the reticular dermis and, sometimes, the subcutaneous fat. Histiocytes monopolize in leprom…

Histologic Diagnosis of Inflammatory Skin Diseases

Erythema nodosum leprosum

…ar panniculitis, focal at first and then diffuse Patchy zones of extensive fat necrosis Foam cells scattered in fat lobules In fibrous septa of the subcutaneous fat, fibrin in the wall of some small vessels and thrombi in the lumen of others Sparse i…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Perforating Diseases?

…n-eosin rather than the usual light blue), neutrophils, and nuclear debris of neutrophils. One thing is certain: the direction of movement of altered elastic fibers is from the dermis to the skin surface, a phenomenon that also has been dubbed &#8220…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Pernio, Perniosis, Lupus Pernio, Chilblain, and Chilblain Lupus?

…onal microscopy Superficial and deep perivascular infiltrates of lymphocytes Superficial and deep perivascular infiltrates of lymphocytes Laboratory investigation Antinuclear antibody positive Antinuclear antibody positive DIFFERENCES Distribution of…