Histologic Diagnosis of Inflammatory Skin Diseases

Erythema nodosum leprosum

…ar panniculitis, focal at first and then diffuse Patchy zones of extensive fat necrosis Foam cells scattered in fat lobules In fibrous septa of the subcutaneous fat, fibrin in the wall of some small vessels and thrombi in the lumen of others Sparse i…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Perforating Diseases?

…n-eosin rather than the usual light blue), neutrophils, and nuclear debris of neutrophils. One thing is certain: the direction of movement of altered elastic fibers is from the dermis to the skin surface, a phenomenon that also has been dubbed &#8220…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Pernio, Perniosis, Lupus Pernio, Chilblain, and Chilblain Lupus?

…onal microscopy Superficial and deep perivascular infiltrates of lymphocytes Superficial and deep perivascular infiltrates of lymphocytes Laboratory investigation Antinuclear antibody positive Antinuclear antibody positive DIFFERENCES Distrib…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Pseudopelade?

…oid, is characterized by acute folliculitis with inflammation of the dermis in the zone of involvement.” Brocq L. Recherches sur l”alopecie atrophiante, vari?t? pseudopelade [Research about atrophic alopecia, pseudopelade variant]. Ann D…

Histologic Diagnosis of Inflammatory Skin Diseases

Hailey-Hailey disease

…as thought by them and by others in the ensuing years to be a variant of pemphigus vulgaris. The reasons for that misinterpretation were the flaccidity of the blisters clinically and the acantholytic cells in the epidermis histopathologically. Despit…

Histologic Diagnosis of Inflammatory Skin Diseases

Leprosy

…onventional polar manifestations and intermediate expressions of leprosy result from dense nodular or diffuse infiltrates of mononuclear inflammatory cells in the reticular dermis and, sometimes, the subcutaneous fat. Histiocytes monopolize in leprom…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Lymphocytic Infiltration of Jessner?

…ys, around vessels and/or appendages. The infiltrates consist of lymphocytes, mostly small ones, and usually a few histiocytes and plasma cells.” Jessner M, Kanof NB, Orfuss AJ. Lymphocytic infiltration of the skin. Arch Dermatol 1953;68:447&#…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Necrotizing Vasculitis?

…ts in vasculitis is best illustrated in necrotizing venulitis of the superficial dermal plexus, where fibrillar and amorphous eosinophilic material is deposited within the vessel wall, which is infiltrated by polymorphonuclear leukocytes and becomes…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Malignant Spitz Nevus?

“A rare malignant variant of the Spitz naevus has been reported which features a higher mitotic rate and subcutaneous invasion. It may metastasize to the regional lymph nodes but not beyond.” Weedon D, Stratton G. Malignant melanoma pa…