Histologic Diagnosis of Inflammatory Skin Diseases

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…looning, intraepidermal vesiculation, or neutrophils in mounds of parakeratosis; in fact, spongiosis in slight and the thickened cornified layer is devoid of inflammatory cells. 10.66.14A: Vesicular dermatitis, ostensibly subepidermal, and peri…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Figurate Erythemas?

…uperficial and deep, mostly perivascular, and usually composed of a mix of cells. If the biopsy specimen comes from near the site of the inciting “bite”, numerous eosinophils are present in the infiltrate. If it comes from the outer margi…

Histologic Diagnosis of Inflammatory Skin Diseases

Miescher’s granuloma of the face

…m Both are unknown. Comment Whether Miescher’s granuloma of the face, a diagnosis made rarely, is a specific disease or a mere variant of granuloma annulare has yet to be determined. The findings are limited to the reticular dermis, where histi…

Differential Diagnosis in Dermatopathology

Apocrine mixed tumor vs. Eccrine mixed tumor

A benign neoplasm of apocrine ductal nature within the upper half of the dermis that manifests itself clinically as tiny, smooth, skin-colored, round or oblong papules that usually are situated in periorbital skin, but may be seen on other sites, su…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Dandruff a Disease?

….” The stratum disjunctum represents histologic evidence of exfoliation of cornified cells from normal skin. In actuality, dandruff is simply the visible gross expression of the “stratum disjunctum.” It is constituted of orthokerato…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Diabetic Dermopathy?

…athy, nor do we observe any sign of vasculitis. In their study of changes histopathologic of diabetic dermopathy, Binkley, Gerolds, and Stoughton found … thick-walled capillaries in the upper dermis. The endothelial cells are prominent. The adv…