Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Necrotizing Vasculitis?

…ts in vasculitis is best illustrated in necrotizing venulitis of the superficial dermal plexus, where fibrillar and amorphous eosinophilic material is deposited within the vessel wall, which is infiltrated by polymorphonuclear leukocytes and becomes…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Malignant Spitz Nevus?

“A rare malignant variant of the Spitz naevus has been reported which features a higher mitotic rate and subcutaneous invasion. It may metastasize to the regional lymph nodes but not beyond.” Weedon D, Stratton G. Malignant melanoma pa…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…rmal spinous layer in association with incipient acantholytic cells = Impetigo contagiosa Only the presence of bacteria in the cytoplasm of some neutrophils enables a diagnosis of impetigo to be made with surety. Otherwise, the findings histopatholog…

Differential Diagnosis in Dermatopathology

Apocrine mixed tumor vs. Eccrine mixed tumor

A benign neoplasm of apocrine ductal nature within the upper half of the dermis that manifests itself clinically as tiny, smooth, skin-colored, round or oblong papules that usually are situated in periorbital skin, but may be seen on other sites, su…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Dandruff a Disease?

…” The stratum disjunctum represents histologic evidence of exfoliation of cornified cells from normal skin. In actuality, dandruff is simply the visible gross expression of the “stratum disjunctum.” It is constituted of orthokeratot…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Diabetic Dermopathy?

…sels became less and less competent with formation inevitably of aneurysms. Secondary to those saccular dilations, serum leaked into tissues. Later still, endothelial cells also became fewer in number and, in time, some blood vessels actually vanishe…