Histologic Diagnosis of Inflammatory Skin Diseases

Erythema nodosum leprosum

…lar panniculitis, focal at first and then diffuse Patchy zones of extensive fat necrosis Foam cells scattered in fat lobules In fibrous septa of the subcutaneous fat, fibrin in the wall of some small vessels and thrombi in the lumen of others Sparse…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…tigo contagiosa Only the presence of bacteria in the cytoplasm of some neutrophils enables a diagnosis of impetigo to be made with surety. Otherwise, the findings histopathologic are indistinguishable from those of pemphigus foliaceus, including the…

Histologic Diagnosis of Inflammatory Skin Diseases

Leprosy

…conventional polar manifestations and intermediate expressions of leprosy result from dense nodular or diffuse infiltrates of mononuclear inflammatory cells in the reticular dermis and, sometimes, the subcutaneous fat. Histiocytes monopolize in lepro…

Differential Diagnosis in Dermatopathology

Apocrine mixed tumor vs. Eccrine mixed tumor

A benign neoplasm of apocrine ductal nature within the upper half of the dermis that manifests itself clinically as tiny, smooth, skin-colored, round or oblong papules that usually are situated in periorbital skin, but may be seen on other sites, su…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Diabetic Dermopathy?

…athy, nor do we observe any sign of vasculitis. In their study of changes histopathologic of diabetic dermopathy, Binkley, Gerolds, and Stoughton found … thick-walled capillaries in the upper dermis. The endothelial cells are prominent. The adv…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Dandruff a Disease?

….” The stratum disjunctum represents histologic evidence of exfoliation of cornified cells from normal skin. In actuality, dandruff is simply the visible gross expression of the “stratum disjunctum.” It is constituted of orthokerato…