Histologic Diagnosis of Inflammatory Skin Diseases

Erythema nodosum

Erythema nodosum Synonyms Erythema contusiforme Erythema contusiformis Dermatitis contusiformis Erythema nouesux Presentation stereotypical Age and sex Young adults, especially women Distribution of lesions Bilateral and symmetrical over the pretibi…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…tes in diseases that erupt, such as erythema multiforme, fixed drug eruption, and Mucha-Habermann disease, are situated in the lower part of the epidermis. 10.53.3A: Vesicular dermatitis, intraepidermal, ballooned and spongiotic + 10.53.3B:…

Histologic Diagnosis of Inflammatory Skin Diseases

Leprosy

Leprosy Synonyms Hansen’s disease Lepra Presentation stereotypical Age and sex Young adults of both sexes who live in endemic areas Distribution of lesions Localized in indeterminate and tuberculoid types; widespread and symmetrical in lepro…

Histologic Diagnosis of Inflammatory Skin Diseases

Pruritic urticarial papules and plaques of pregnancy

…ic urticarial papules and plaques of pregnancy also includes a drug eruption of one type. Time was, not too many years ago, when it was claimed that there were no small number of “dermatoses of pregnancy.” For purposes practical there are…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…of eosinophils. 10.27.2A: Perivascular and interstitial dermatitis + 10.27.2B: Lymphocytes and eosinophils in and around an infundibulosebaceous unit, and scattered among bundles of collagen = Papular dermatitis of HIV The changes pictured…

Histologic Diagnosis of Inflammatory Skin Diseases

Nerves

…associated with itching; among the most notorious of these are dermatitis herpetiformis, Grover’s disease, and scabies. Scratching is thought to relieve itching by disturbing the rhythm of afferent impulses that travel toward the central nervou…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Focus of Infection?

…4, herpes zoster; 5, eczema (neurotic); 6, alopecia areata; 7, dermatitis herpetiformis; 8, scleroderma; 9, vitiligo. Group 3: Those considered in some relation with tuberculosis:            1, erythema induratum; 2, lupus erythematosus; 3, lupus vul…

Histologic Diagnosis of Inflammatory Skin Diseases

Fixation of the Specimen

…us diseases, e.g., bullous pemphigoid, pemphigus vulgaris, and dermatitis herpetiformis. When diagnosis with precision of a vesiculobullous disease is the goal, a biopsy specimen for direct immunofluorescence must be taken from skin contiguous to a n…

Histologic Diagnosis of Inflammatory Skin Diseases

Introduction

…, among a discrete number of possibilities, for example, among dermatitis herpetiformis, linear IgA dermatosis, and bullous lupus erythematosus. In those situations, direct immunofluorescence can be invaluable in arriving at the single, correct diagn…