Histologic Diagnosis of Inflammatory Skin Diseases

Pruritic urticarial papules and plaques of pregnancy

…tends to be slight and does not eventuate in vesiculation, unlike the situation in some responses to the assault of arthropods. The differential diagnosis of pruritic urticarial papules and plaques of pregnancy also includes a drug eruption of one t…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…es in diseases that erupt, such as erythema multiforme, fixed drug eruption, and Mucha-Habermann disease, are situated in the lower part of the epidermis. 10.53.3A: Vesicular dermatitis, intraepidermal, ballooned and spongiotic + 10.53.3B:…

Histologic Diagnosis of Inflammatory Skin Diseases

Leprosy

…f lymphocytes that spare cutaneous nerves. Polymorphous light eruption differs from indeterminate leprosy by the presence, often, of notable edema in the papillary dermis. The tumid variant of discoid lupus erythematosus differs from indeterminate le…

Histologic Diagnosis of Inflammatory Skin Diseases

Fixation of the Specimen

…s diseases, e.g., bullous pemphigoid, pemphigus vulgaris, and dermatitis herpetiformis. When diagnosis with precision of a vesiculobullous disease is the goal, a biopsy specimen for direct immunofluorescence must be taken from skin contiguous to a ne…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Focus of Infection?

…, herpes zoster; 5, eczema (neurotic); 6, alopecia areata; 7, dermatitis herpetiformis; 8, scleroderma; 9, vitiligo. Group 3: Those considered in some relation with tuberculosis:            1, erythema induratum; 2, lupus erythematosus; 3, lupus vulg…

Histologic Diagnosis of Inflammatory Skin Diseases

Introduction

…among a discrete number of possibilities, for example, among dermatitis herpetiformis, linear IgA dermatosis, and bullous lupus erythematosus. In those situations, direct immunofluorescence can be invaluable in arriving at the single, correct diagno…

Histologic Diagnosis of Inflammatory Skin Diseases

Nerves

…ssociated with itching; among the most notorious of these are dermatitis herpetiformis, Grover’s disease, and scabies. Scratching is thought to relieve itching by disturbing the rhythm of afferent impulses that travel toward the central nervous…

Differential Diagnosis in Dermatopathology

Herpes simplex vs. Vaccinia

An inflammatory disease of genetic nature that begins with red macules that quickly become nonscaly papules that in turn become scaly papules and plaques. If the process becomes widespread, an erythroderma results, and if it is accelerated, pustules…