Histologic Diagnosis of Inflammatory Skin Diseases

Pruritic urticarial papules and plaques of pregnancy

…ic urticarial papules and plaques of pregnancy also includes a drug eruption of one type. Time was, not too many years ago, when it was claimed that there were no small number of “dermatoses of pregnancy.” For purposes practical there are…

Histologic Diagnosis of Inflammatory Skin Diseases

Introduction

…, among a discrete number of possibilities, for example, among dermatitis herpetiformis, linear IgA dermatosis, and bullous lupus erythematosus. In those situations, direct immunofluorescence can be invaluable in arriving at the single, correct diagn…

Histologic Diagnosis of Inflammatory Skin Diseases

Fixation of the Specimen

…us diseases, e.g., bullous pemphigoid, pemphigus vulgaris, and dermatitis herpetiformis. When diagnosis with precision of a vesiculobullous disease is the goal, a biopsy specimen for direct immunofluorescence must be taken from skin contiguous to a n…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Focus of Infection?

…4, herpes zoster; 5, eczema (neurotic); 6, alopecia areata; 7, dermatitis herpetiformis; 8, scleroderma; 9, vitiligo. Group 3: Those considered in some relation with tuberculosis:            1, erythema induratum; 2, lupus erythematosus; 3, lupus vul…

Histologic Diagnosis of Inflammatory Skin Diseases

Nerves

…associated with itching; among the most notorious of these are dermatitis herpetiformis, Grover’s disease, and scabies. Scratching is thought to relieve itching by disturbing the rhythm of afferent impulses that travel toward the central nervou…

Differential Diagnosis in Dermatopathology

Herpes simplex vs. Vaccinia

An inflammatory disease of genetic nature that begins with red macules that quickly become nonscaly papules that in turn become scaly papules and plaques. If the process becomes widespread, an erythroderma results, and if it is accelerated, pustules…

Differential Diagnosis in Dermatopathology

Discussions

…cy for vesicles to form rapidly and in clusters, as they do in dermatitis herpetiformis and herpes gestationis, neither of which has been shown to be viral in cause. When herpes simplex or zoster/varicella occurs in patients with other skin diseases…

Differential Diagnosis in Dermatopathology

Images

Dermatitis herpetiformis Bullous pemphigoid…