Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 10.88.1A: Perivascular dermatitis, neutrophils predominant + 10.88.1B: Neutrophils in edematous dermal papillae = Prurigo pigmentosa ¬†Findings similar to these may be seen in dermatitis herpetiformis at a very early stage of the pr…

Histologic Diagnosis of Inflammatory Skin Diseases

Irritant contact dermatitis/Phototoxic dermatitis

…ltrate of lymphocytes and neutrophils Slight spongiosis Slight ballooning Individual necrotic keratocytes in the epidermis Fully developed Same changes as in an early lesion plus: Prominent ballooning Intraepidermal vesicles associated with reticul…

Differential Diagnosis in Dermatopathology

Discussions

…lmost always the intraepidermal blister comes about because of ballooning. In both diseases, ballooning tends to progress to vesiculation affiliated with reticular alteration which is associated invariably with necrosis en masse of keratocytes. Eryth…

Differential Diagnosis in Dermatopathology

Discussions

…dermatitis is characterized by spongiosis with little, if any, ballooning, in contrast to the situation in phototoxic dermatitis where ballooning of keratocytes is prominent and spongiosis is not. Severe ballooning in phototoxic dermatitis, accompani…

Histologic Diagnosis of Inflammatory Skin Diseases

Limitations of the Algorithmic Method

The algorithmic method proposed in these pages and predicated on patterns histopathologic is intended to be more than just a guide to diagnosis of particular pathologic processes in skin and subcutaneous fat; it is meant to serve as a springboard fo…

Histologic Diagnosis of Inflammatory Skin Diseases

Drug eruptions

Drug eruptions Synonyms Dermatitis medicamentosa Presentation stereotypical Age and sex Any age or either sex, but most common in older persons who take many medications. Immunosuppressed patients, among them those infected with the human immunodefi…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 10.11.1A: Vesicular dermatosis, intraepidermal, ballooned + 10.11.1B: Ballooned keratocytes and confluent epidermal necrosis = Thermal burn This is not a true dermatitis because there is no infiltrate of inflammatory cells. It is a…

Histologic Diagnosis of Inflammatory Skin Diseases

Measles

…rate of lymphocytes Slight acanthosis Slight spongiosis Slight ballooning Few individual necrotic keratocytes in the spinous zone, especially in the vicinity of ballooning Few multinucleate epithelial giant cells in foci of spongiosis and ballooning