Histologic Diagnosis of Inflammatory Skin Diseases

Urticaria pigmentosa

…s are formed by dense diffuse monomorphous infiltrates of mast cells. Smaller versions of them, i.e., dome-shaped papules, are made up of fewer mast cells lodged superficially in the dermis. Bullae result from extensive subepidermal edema that lifts…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Dermal Papilla?

…220;Historically, the hair germ has been defined as a group of cells located at the base of the telogen follicle in close contact with the dermal papilla.” Lavker RM, Miller S, Wilson C, et al. Hair follicle stem cells: their location, role in…

Histologic Diagnosis of Inflammatory Skin Diseases

Errors and Reasons

….g., bouts of fever and the stress of parturition, on matrical cells in the bulb of follicles, so-called anagen effluvium results from the effects on those cells of chemotherapy administered systemically. Error: Anetoderma comes into being from loss…

Histologic Diagnosis of Inflammatory Skin Diseases

The Algorithmic Method

…at higher magnification, of the kind or kinds of inflammatory cells (or neoplastic lymphocytes, Langerhans” cells, and mast cells that, at first blush, may appear to be inflammatory cells) that make up the infiltrate. Remarkable as it may seem…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Cytophagic Panniculitis?

…of histiocytic cells with associated T-lymphocytes and plasma cells. The histiocytes are cytophagic so that they become stuffed with white blood cells, red cells, nuclear fragments and platelets, and this gives them a characteristic “bean bag&…

Histologic Diagnosis of Inflammatory Skin Diseases

Eccrine Units

…raverses the dermis. The coiled gland is formed of two rows of cells (Fig. 1.57), namely, (1) a discontinuous outer row of spindle-shaped, contractile myoepithelial cells and (2) an inner row of pyramidal, secretory epithelial cells. The single inner…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Apoptosis?

…nvolutional stage of a repeatable cycle in which numerous dead cells appear as solitary units in the lower segment of the follicle, at first in the bulb and, in a short time, the stem. As a consequence of the death of those epithelial cells, the bulb…