Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Dermal Papilla?

…20;Historically, the hair germ has been defined as a group of cells located at the base of the telogen follicle in close contact with the dermal papilla.” Lavker RM, Miller S, Wilson C, et al. Hair follicle stem cells: their location, role in…

Histologic Diagnosis of Inflammatory Skin Diseases

Errors and Reasons

…r: “Acute” and “chronic” inflammatory cells are characterizations accurately of neutrophils and eosinophils on one hand and of lymphocytes and histiocytes on the other. Reason: Because neutrophils and eosinophils may be presen…

Histologic Diagnosis of Inflammatory Skin Diseases

The Algorithmic Method

…at higher magnification, of the kind or kinds of inflammatory cells (or neoplastic lymphocytes, Langerhans” cells, and mast cells that, at first blush, may appear to be inflammatory cells) that make up the infiltrate. Remarkable as it may seem,…

Histologic Diagnosis of Inflammatory Skin Diseases

Eccrine Units

…averses the dermis. The coiled gland is formed of two rows of cells (Fig. 1.57), namely, (1) a discontinuous outer row of spindle-shaped, contractile myoepithelial cells and (2) an inner row of pyramidal, secretory epithelial cells. The single inner…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Apoptosis?

…volutional stage of a repeatable cycle in which numerous dead cells appear as solitary units in the lower segment of the follicle, at first in the bulb and, in a short time, the stem. As a consequence of the death of those epithelial cells, the bulb…

Histologic Diagnosis of Inflammatory Skin Diseases

Blood Vessels

…els in the skin of an embryo come into being when mesenchymal cells arranged in an intricate network arborize and encircle conduits that are seen through a microscope as mere spaces. The dermal vasculature consists of a superficial and a deep plexus…

Dermatology Practical & Conceptual

Langerhans cell histiocytosis-a case report

…d revealed a dense cellular infiltrate made up of mononuclear cells with conspicuous eosinophilic cytoplasm and large cleaved vesicular nucleus, some of them with shapes resembling the format of a kidney and others reminiscent of coffee beans. Numero…

Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Vasculitis

…el vasculitis in the setting of an infiltrate of inflammatory cells are the presence of fibrin in the wall of venules and/or thrombi in the lumen of them. In contrast, there is but a single criterion for recognition by conventional microscopy of larg…