Search Results for: cleft

Histologic Diagnosis of Inflammatory Skin Diseases

Grover’s disease

…holytic dyskeratotic cells may be found just above suprabasal clefts in an epidermis that otherwise is mostly cohesive, they may be unassociated with parakeratosis (pemphigus vulgaris type), they may be present above suprabasal clefts in an epidermis…

Differential Diagnosis in Dermatopathology

Discussions

…the acantholytic dyskeratotic cells appear above a suprabasal cleft, not in a suprabasal vesicle. In the pure Darier type of Grover’s disease, the findings are those of true focal acantholytic dyskeratosis. In other variants histopathologic of…

Differential Diagnosis in Dermatopathology

Discussions

…, smooth border, compression of enveloping connective tissue, clefts between compressed fibrous tissue and normal dermis or subcutaneous fat, tendency to “pop out” and “shell out,” and monomorphic nuclei of neoplastic cells. I…

Histologic Diagnosis of Inflammatory Skin Diseases

Fixed drug eruption

…oepidermal junction; if extensive, eventuates in subepidermal clefts and subepidermal vesicles Marked spongiosis and ballooning; if ballooning extensive sufficiently, reticular alteration and intraepidermal vesicles ensue Intraepidermal and subepider…

Dermatology Practical & Conceptual

Tufted hemangioma: clinical case and literature review

…mall tufts with a cannonball distribution, encircled by empty cleft-like vessels and often surrounded by sclerotic dermis. Tufts are composed of epithelioid and spindle cells with slit-like spaces resembling Kaposi sarcoma. Hyaline globules may be se…

Differential Diagnosis in Dermatopathology

Discussions

…f clusters of those cells to “schools of fish.” A cleft often surrounds each of the distinctive polygonal melanocytes. When viewed by conventional microscopy, melanocytes of desmoplastic Spitz’s nevus may contain no melanin, a barel…

Histologic Diagnosis of Inflammatory Skin Diseases

Epidermolysis bullosa simplex

…Vacuoles in epidermal basal cells at the sides of the blister Clefts cut a swath through epidermal basal cells Little or no infiltrate of inflammatory cells Late Re-epithelization of epidermis beneath a blister whose roof is composed of stratum spino…