Search Results for: cleft

Histologic Diagnosis of Inflammatory Skin Diseases

Lichen planus

…s). A distinction must be made between subepidermal spaces or clefts (Max Joseph spaces) that tend to form in sections of specimens removed from papules of conventional lichen planus and blisters that appear in the uncommon vesicular (“bullous&…

Differential Diagnosis in Dermatopathology

Discussions

…, smooth border, compression of enveloping connective tissue, clefts between compressed fibrous tissue and normal dermis or subcutaneous fat, tendency to “pop out” and “shell out,” and monomorphic nuclei of neoplastic cells. I…

Histologic Diagnosis of Inflammatory Skin Diseases

Fixed drug eruption

…oepidermal junction; if extensive, eventuates in subepidermal clefts and subepidermal vesicles Marked spongiosis and ballooning; if ballooning extensive sufficiently, reticular alteration and intraepidermal vesicles ensue Intraepidermal and subepider…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…morphea. 10.97.13A: Perivascular dermatitis and subepidermal cleft + 10.97.13B: Crowded thickened bundles of collagen in the upper part of the dermis, an infundibulum plugged by corneocytes, a thinned surface epidermis, and compact orthokeratosis =…

Differential Diagnosis in Dermatopathology

Discussions

…the acantholytic dyskeratotic cells appear above a suprabasal cleft, not in a suprabasal vesicle. In the pure Darier type of Grover’s disease, the findings are those of true focal acantholytic dyskeratosis. In other variants histopathologic of…

Differential Diagnosis in Dermatopathology

Discussions

…f clusters of those cells to “schools of fish.” A cleft often surrounds each of the distinctive polygonal melanocytes. When viewed by conventional microscopy, melanocytes of desmoplastic Spitz’s nevus may contain no melanin, a barel…