Histologic Diagnosis of Inflammatory Skin Diseases

Fixed drug eruption

Fixed drug eruption Synonyms Fixed toxic exanthem Presentation stereotypical Age and sex Adults of both sexes Distribution of lesions Lips, genital region, and limbs especially Configuration of lesions Round Arrangement of lesions Solitary or few, d…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

10.97.1A: Perivascular and interstitial dermatitis + 10.97.1B: Neutrophils, eosinophils, lymphocytes, and plasma cells in the interstitium of the reticular dermis = Morphea, early ┬áThe changes shown represent an early stage in a longstand…

Differential Diagnosis in Dermatopathology

Discussions

Darier’s disease and Grover’s disease have several findings histopathologic in common, among them foci of acantholytic dyskeratotic cells in the epidermis and a superficial perivascular infiltrate of inflammatory cells, usually lymphocyt…

Differential Diagnosis in Dermatopathology

Discussions

The neoplasms under discussion here are termed “mixed tumors” because they consist of a combination of epithelial elements with tubular differentiation on one hand and non-epithelial elements with mucinous and chondroid aspects, but they…

Dermatology Practical & Conceptual

Tufted hemangioma: clinical case and literature review

Abstract Tufted hemangiomas are relatively rare benign vascular proliferations that are congenital or appear during the first years of life. Herein we present an additional case of tufted hemangioma that appeared one year after birth and discuss its…

Histologic Diagnosis of Inflammatory Skin Diseases

Epidermolysis bullosa simplex

Epidermolysis bullosa simplex Presentation stereotypical Age and sex Shortly after birth or during childhood and adolescence; both sexes affected Distribution of lesions Varies according to type of epidermolysis bullosa (see Variations clinical) Ind…

Differential Diagnosis in Dermatopathology

Discussions

Despite the differences biologic between dermatofibroma (an inflammatory process) and desmoplastic (fibrosing, largely intradermal) Spitz’s nevus (a benign neoplastic process), the two conditions have many attributes morphologic in common. Bot…

Differential Diagnosis in Dermatopathology

Apocrine mixed tumor vs. Eccrine mixed tumor

A genetically determined disorder in which numerous closely set keratotic papules are present on the skin, especially the trunk, in nail units, and on mucous membranes, particularly the palate, but also rarely in other parts of the gastrointestinal…

Differential Diagnosis in Dermatopathology

Dermatofibroma vs. Desmoplastic Spitz’s nevus

A genetically determined disorder in which numerous closely set keratotic papules are present on the skin, especially the trunk, in nail units, and on mucous membranes, particularly the palate, but also rarely in other parts of the gastrointestinal…