Search Results for: collagen

Histologic Diagnosis of Inflammatory Skin Diseases

Dermoepithelial Interface

…atients with recessive and dominant dystrophic kinds of epidermolysis bullosa are responsible for an abnormality in Type VII collagen and immunologic damage to Type VII collagen is the cause of acquired epidermolysis bullosa and bullous lupus…

Histologic Diagnosis of Inflammatory Skin Diseases

Rheumatoid nodule

…f palisades in resolving ones; granulomatous and fibrosing septal panniculitis is an accompaniment common. Injectable bovine collagen consists of thick bundles of collagen and not of fibrillary material (fibrin). Laboratory confirmation Rheumatoid…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…pecimen was taken by saucerization technique. 10.96.2A: Fibrosing dermatitis + 10.96.2B: Plump fibrocytes, coarse bundles of collagen in haphazard array, and abundant mucin in interstices between collagen bundles = Scar, early As lesions of scars…

Histologic Diagnosis of Inflammatory Skin Diseases

Mycosis fungoides

…pidermal rete ridges having been obliterated, or nearly so; what remains of the upper part of the dermis are wiry bundles of collagen arrayed randomly and associated with a relatively sparse infiltrate of lymphocytes. The loss of dermal papillae and…

Differential Diagnosis in Dermatopathology

Morphea, late stage vs. Collagenous nevus

…at least two different inflammatory diseases that have in common hardening of the skin by virtue of thickening of bundles of collagen in the dermis and subcutis. One of those diseases manifests itself as localized or widespread patches and plaques…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…seen in rheumatoid arthritis. The presumed sequence of events is small-vessel vasculitis, infarction, marked degeneration of collagen, and palisaded granulomatous inflammation as a foreign body response to the altered collagen. Such events seem to…

Histologic Diagnosis of Inflammatory Skin Diseases

Reactive perforating collagenosis

…e of severe injury to the upper part of the dermis as a consequence of trauma external. The name “reactive perforating collagenosis” was given because bundles of degenerated collagen seemed, to those who described the condition…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Scleroderma?

…Berlin: Springer-Verlag, 1991:553. “The term scleroderma refers to a group of diseases in which there is deposition of collagen in the skin and sometimes other organs as well. It may occur as localized cutaneous disease in which the disorder…