Search Results for: collagen

Histologic Diagnosis of Inflammatory Skin Diseases

Dermoepithelial Interface

…nd downward from the basal lamina to interweave with type III collagen fibers (CF) in the papillary dermis. (Art by Mario DiLeonardo, M.D., from AB Ackerman, H Jacubovic. In: Moschella SL, Hurley HJ, eds. Dermatology, 3rd ed. Philadelphia: W.B. Saund…

Histologic Diagnosis of Inflammatory Skin Diseases

Rheumatoid nodule

…dominant in the center of the palisade of mesenchymal cells, collagen bundles, crowded and thickened, are replacements. Correlation clinicopathologic The nodules consist of discrete zones formed mostly of huge deposits of fibrin that are surrounded…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…ng dermatitis + 10.96.1B: Plump fibrocytes, coarse bundles of collagen in haphazard array, and patchy infiltrate of iron-containing macrophages = Scar, very early  Innumerable macrophages replete with iron bear testimony to application at this site o…

Histologic Diagnosis of Inflammatory Skin Diseases

Mycosis fungoides

…cytes in a papillary dermis thickened also by wiry bundles of collagen in haphazard array Loss of the usual undulate pattern between dermal papillae and of epidermal rete ridges Lymphocytes disposed as solitary units within the basal layer of the epi…

Differential Diagnosis in Dermatopathology

Morphea, late stage vs. Collagenous nevus

…n hardening of the skin by virtue of thickening of bundles of collagen in the dermis and subcutis. One of those diseases manifests itself as localized or widespread patches and plaques (morphea) and by localized linear lesions (linear scleroderma), w…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…uolar + 10.63.5B: Lymphocytes only and abundant mucin between collagen bundles in the reticular dermis + 10.63.5C + 10.63.5D = Lupus erythematosus, discoid  The pink globules in the uppermost part of the dermis represent necrotic keratocytes, a conse…

Histologic Diagnosis of Inflammatory Skin Diseases

Reactive perforating collagenosis

Reactive perforating collagenosis Presentation stereotypical Age and sex Any age, both sexes Distribution of lesions Asymmetric at sites of trauma; sometimes symmetrical Arrangement of lesions May be linear Individual lesions Ulcerated papules toppe…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Scleroderma?

…septa of the subcutaneous fat, crowded, thickened bundles of collagen arranged mostly parallel to the skin surface, and in the subcutaneous fat crowded thickened bundles of collagen arranged parallel to widened septa. Those findings present themselv…