Histologic Diagnosis of Inflammatory Skin Diseases

Dermoepithelial Interface

…tensive network in the sub-lamina densa, one that acts to trap collagen and, in the process, attaches the lamina densa to the papillary dermis. Anchoring fibrils are made up of several components, among them Type VII collagen, those being restricted…

Histologic Diagnosis of Inflammatory Skin Diseases

Rheumatoid nodule

…, fibrin. Necrobiosis lipoidica shows striking degeneration of collagen in the center of palisades of histiocytes in evolving lesions and thickened bundles of collagen in the center of palisades in resolving ones; granulomatous and fibrosing septal p…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…dermatitis + 10.96.2B: Plump fibrocytes, coarse bundles of collagen in haphazard array, and abundant mucin in interstices between collagen bundles = Scar, early ¬†As lesions of scars and keloids evolve, fibrocytes not only manufacture collagen, bu…

Differential Diagnosis in Dermatopathology

Morphea, late stage vs. Collagenous nevus

A generic term for at least two different inflammatory diseases that have in common hardening of the skin by virtue of thickening of bundles of collagen in the dermis and subcutis. One of those diseases manifests itself as localized or widespread pa…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…is small-vessel vasculitis, infarction, marked degeneration of collagen, and palisaded granulomatous inflammation as a foreign body response to the altered collagen. Such events seem to be dependent on the presence of anticardiolipin antibodies….

Histologic Diagnosis of Inflammatory Skin Diseases

Reactive perforating collagenosis

…f neutrophils situated beneath an ulcer Bundles of degenerated collagen at the base of an ulcer Ulcer beneath a prominent crust Collagen bundles, some showing signs of degeneration, in a large crust replete with neutrophils Correlation clinicopathol…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Scleroderma?

…d septa of the subcutaneous fat, crowded, thickened bundles of collagen arranged mostly parallel to the skin surface, and in the subcutaneous fat crowded thickened bundles of collagen arranged parallel to widened septa. Those findings present themsel…