Histologic Diagnosis of Inflammatory Skin Diseases

Eosinophilic folliculitis

…rough papules often reveal suppurative infundibulitis rich in eosinophils. Differential diagnosis clinical Suppurative infundibulitis of another kind, either infectious or noninfectious, may be indistinguishable. Insect “bites” induce pa…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…icular dermatitis, intraepidermal, spongiotic + 10.50.1B: Eosinophils in contiguity with numerous necrotic keratocytes = Incontinentia pigmenti, vesicular stage Inflammatory cells (in this case eosinophils) en route from the papillary dermis to t…

Histologic Diagnosis of Inflammatory Skin Diseases

Pemphigus vulgaris

…itial infiltrate of lymphocytes around venules and, at times, eosinophils and neutrophils in the interstitium Vacuoles between cells in the basal layer and spinous zone of the epidermis (surface and infundibular) and of epithelial structures of adnex…

Histologic Diagnosis of Inflammatory Skin Diseases

Pruritic urticarial papules and plaques of pregnancy

…ly Superficial perivascular infiltrate of lymphocytes; a few eosinophils scattered interstitially in most instances Fully developed Slightly denser perivascular and interstitial infiltrate of inflammatory cells in the upper half of the dermis; lym…

Histologic Diagnosis of Inflammatory Skin Diseases

Kimura’s disease

…ed Massive nodular and diffuse infiltrate of lymphocytes and eosinophils throughout the reticular dermis and subcutaneous tissue and, sometimes, in fascia and even skeletal muscle Many lymphoid follicles joined by innumerable eosinophils Fibroplasia…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…e dermatosis + 11.23.5B: Mast cells mostly, but also many eosinophils = Urticaria pigmentosa  After a lesion such as this one has been rubbed forcefully, eosinophils from the blood are drawn rapidly to the infiltrate made up of mast cells, that b…

Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Pustular Dermatitis

…ndibulocentric and characterized by infiltration of countless eosinophils, those granulocytes tending to fill the infundibular canal to the point of breaking. The myriad eosinophils are accompanied by neutrophils that seem to be paltry in comparison….