Histologic Diagnosis of Inflammatory Skin Diseases

Eosinophilic folliculitis

…cular infiltrate of lymphocytes and interstitial infiltrate of eosinophils mostly, but neutrophils, too Collections of eosinophils, but also neutrophils, in one or more infundibula Collections of eosinophils and neutrophils around infundibula that ha…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…sicular dermatitis, intraepidermal, spongiotic + 10.50.1B: Eosinophils in contiguity with numerous necrotic keratocytes = Incontinentia pigmenti, vesicular stage Inflammatory cells (in this case eosinophils) en route from the papillary dermis to…

Histologic Diagnosis of Inflammatory Skin Diseases

Pemphigus vulgaris

…associated with acantholytic cells, impressive collections of eosinophils, and crusts that contain eosinophils. Clues to specific diagnosis histopathologic Scatter of eosinophils, mostly as solitary units, across a broad front of epidermis is a cl…

Histologic Diagnosis of Inflammatory Skin Diseases

Pruritic urticarial papules and plaques of pregnancy

Pruritic urticarial papules and plaques of pregnancy Synonyms Polymorphic eruption of pregnancy Bourne’s toxemic rash of pregnancy Toxemic rash of pregnancy Toxic erythema of pregnancy Nurse’s late onset prurigo of pregnancy Presentati…

Histologic Diagnosis of Inflammatory Skin Diseases

Kimura’s disease

…ped Massive nodular and diffuse infiltrate of lymphocytes and eosinophils throughout the reticular dermis and subcutaneous tissue and, sometimes, in fascia and even skeletal muscle Many lymphoid follicles joined by innumerable eosinophils Fibroplasi…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…se dermatosis + 11.23.5B: Mast cells mostly, but also many eosinophils = Urticaria pigmentosa  After a lesion such as this one has been rubbed forcefully, eosinophils from the blood are drawn rapidly to the infiltrate made up of mast cells, that…

Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Pustular Dermatitis

…undibulocentric and characterized by infiltration of countless eosinophils, those granulocytes tending to fill the infundibular canal to the point of breaking. The myriad eosinophils are accompanied by neutrophils that seem to be paltry in comparison…