Histologic Diagnosis of Inflammatory Skin Diseases

Hailey-Hailey disease

…ltrate of lymphocytes mostly In foci in the lower half of the epidermis, vacuoles present between basal cells and spinous cells and between spinous cells themselves Fully developed Moderately dense perivascular and interstitial infiltrate of lympho…

Histologic Diagnosis of Inflammatory Skin Diseases

"Folliculitis" (Infundibulitis)

…practical, is a suppurative process centered in infundibular epidermis, whereas the latter is a suppurative process of follicular epithelium. Presentation stereotypical Age and sex Any age and both sexes Distribution of lesions Any hair-bearing part…

Histologic Diagnosis of Inflammatory Skin Diseases

Herpes gestationis

…nd along the dermoepidermal junction Eosinophils often in the epidermis, as solitary units mostly, but sometimes in tiny collections in conjunction with spongiosis Fully developed (vesicular) Perivascular and interstitial infiltrate of lymphocytes…

Histologic Diagnosis of Inflammatory Skin Diseases

Introduction

…sis and by fissures that form within the abnormally cornified epidermis. In short, without firm grounding in structure and function of skin, a histopathologist lacks a basis for making diagnoses logically of inflammatory skin diseases, and a clinicia…

Histologic Diagnosis of Inflammatory Skin Diseases

Psoriasis

…h a few lymphocytes in discrete foci in the lower part of the epidermis Spongiform and subcorneal pustules in the epidermis of some lesions Hypogranulosis in some foci Mounds of parakeratosis with neutrophils at their summit staggered in the stratum…

Histologic Diagnosis of Inflammatory Skin Diseases

Pigmented Lesions

…the reticular dermis too. Melanin increased in amount in the epidermis. Dermatofibroma¬†(183, 520) Proliferation of fibrocytes and histiocytes (lipophages and siderophages early in the course) in a mass in the reticular dermis, those cells appear…

Histologic Diagnosis of Inflammatory Skin Diseases

Prurigo pigmentosa

…illary dermis Spongiosis in foci Neutrophils scattered in the epidermis Ill-formed abscesses in the epidermis Necrotic keratocytes in the vicinity of neutrophils Fully developed Patchy lichenoid infiltrate of lymphocytes mostly, but also of neutrop…

Histologic Diagnosis of Inflammatory Skin Diseases

Mucha-Habermann disease

…mal junction Individual necrotic keratocytes scattered in the epidermis, especially the lower half; range from few or many Slight spongiosis and ballooning Slight pallor in the upper part of the epidermis Cornified layer basket-weave in configuration…

Histologic Diagnosis of Inflammatory Skin Diseases

Arthropod assaults

…ermis A discrete focus of spongiosis present sometimes in the epidermis at the very site of the “bite,” i.e., directly above the apex of the wedge formed by inflammatory cells whose vertex in the dermis points in the direction of the subc…