Histologic Diagnosis of Inflammatory Skin Diseases

Hand-foot-and-mouth disease

Hand-foot-and-mouth disease Synonyms Enteroviral vesicular stomatitis with exanthem Presentation stereotypical Age and sex Children usually under the age of 10 years and of both sexes; parents of those children affected sometimes Distribution of les…

Differential Diagnosis in Dermatopathology

Discussions

Distinction histopathologic between Mucha-Habermann disease and secondary syphilis may be difficult because the two diseases have so many attributes in common. Both may be associated with a superficial and deep perivascular and lichenoid infiltrate…

Differential Diagnosis in Dermatopathology

Sebaceous hyperplasia vs. Nevus sebaceus of Jadassohn

A small-vessel vasculitis characterized clinically by vesiculopustules on an erythematous base, purpuric macules and papules, and hemorrhagic bullae, and histopathologically by thrombi within venules, a consequence of sepsis….

Differential Diagnosis in Dermatopathology

Differential Diagnosis

Alopecia areata Trichotillomania 1. Sparse infiltrate sometimes of lymphocytes around venules of the superficial and deep plexuses 1. Practically no infiltrate of inflammatory cells 2. In early lesions, infiltrate of lymphocytes in the vicinit…

Differential Diagnosis in Dermatopathology

Alopecia areata vs. Trichotillomania

A small-vessel vasculitis characterized clinically by vesiculopustules on an erythematous base, purpuric macules and papules, and hemorrhagic bullae, and histopathologically by thrombi within venules, a consequence of sepsis….

Differential Diagnosis in Dermatopathology

Mucha-Habermann disease vs. Secondary syphilis

A small-vessel vasculitis characterized clinically by vesiculopustules on an erythematous base, purpuric macules and papules, and hemorrhagic bullae, and histopathologically by thrombi within venules, a consequence of sepsis….

Histologic Diagnosis of Inflammatory Skin Diseases

Pemphigus vulgaris

Pemphigus vulgaris Synonyms Pemphigus major Chronic pemphigus Pemphigus subaigu malin Pemphigus Presentation stereotypical Age and sex Middle-aged persons of both sexes, particularly Ashkenazi Jews Distribution of lesions Restricted usually to the s…

Differential Diagnosis in Dermatopathology

Discussions

Both sebaceous hyperplasia and nevus sebaceus of Jadassohn consist of abnormalities of sebaceous glands but the former, as the name denotes, is a hyperplasia, whereas the latter is a hamartoma that involves not only sebaceous units, but other adnexa…