Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Paraneoplastic Pemphigus?

…criteria to define paraneoplastic pemphigus: painful mucosal erosions and a polymorphous skin eruption, with popular lesions progressing to blisters and erosive lesions affecting the trunk, extremities, and palms and soles, in the context of an occu…

Histologic Diagnosis of Inflammatory Skin Diseases

Hand-foot-and-mouth disease

…lways, by the time a patient seeks medical attention, only an erosion is residual. Intact blisters in the oral cavity, however, show the same changes as do those in the skin. That principle applies to virtually all diseases that affect both skin and…

Differential Diagnosis in Dermatopathology

Discussions

…filtrate of mononuclear cells, acanthosis, parakeratosis, and erosion or ulceration. Erythrocytes are extravasated in the dermis, neutrophils and lymphocytes may be seen in the epidermis, and neutrophils may be trapped in parakeratotic scale-crusts….

Differential Diagnosis in Dermatopathology

Sebaceous hyperplasia vs. Nevus sebaceus of Jadassohn

A small-vessel vasculitis characterized clinically by vesiculopustules on an erythematous base, purpuric macules and papules, and hemorrhagic bullae, and histopathologically by thrombi within venules, a consequence of sepsis….

Differential Diagnosis in Dermatopathology

Differential Diagnosis

…orls of wiry bundles of collagen 9. No imposition of lichen complex chronicus or association of erosion and crusts 9. Lichen simplex chronicus, in the form of compact orthokeratosis, imposed at times; erosions and crusts, are findings uncommonly…

Differential Diagnosis in Dermatopathology

Alopecia areata vs. Trichotillomania

A small-vessel vasculitis characterized clinically by vesiculopustules on an erythematous base, purpuric macules and papules, and hemorrhagic bullae, and histopathologically by thrombi within venules, a consequence of sepsis….

Differential Diagnosis in Dermatopathology

Mucha-Habermann disease vs. Secondary syphilis

A small-vessel vasculitis characterized clinically by vesiculopustules on an erythematous base, purpuric macules and papules, and hemorrhagic bullae, and histopathologically by thrombi within venules, a consequence of sepsis….

Histologic Diagnosis of Inflammatory Skin Diseases

Pemphigus vulgaris

…s Scattered and discrete Individual lesions Vesicles, bullae, erosions, ulcers, and crusts Course Protracted Variations clinical Lesions of pemphigus vulgaris may be confined to mucous membranes entirely, especially oral ones, but sometimes conjunct…

Differential Diagnosis in Dermatopathology

Discussions

…, however, the depression in the center usually represents an erosion or ulceration, whereas in sebaceous hyperplasia it is an ostium formed by a dilated infundibulum or contiguous infundibula. Sebaceous hyperplasia also must be differentiated histop…