Search Results for: fibrin

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Hyalin?

…as erythema elevatum diutinum. That eosinophilic material is fibrin. Hyalin bodies are necrotic keratocytes found in the epidermis or in the upper part of the papillary dermis as a consequence of the destructive effects of inflammatory cells, usuall…

Histologic Diagnosis of Inflammatory Skin Diseases

Erythema nodosum leprosum

…ered in fat lobules In fibrous septa of the subcutaneous fat, fibrin in the wall of some small vessels and thrombi in the lumen of others Sparse infiltrate of neutrophils in fibrous septa Dense infiltrate of neutrophils and histiocytes in the dermis…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Necrobiosis?

…robiotic area contains prominent mucin in granuloma annulare, fibrin in rheumatoid nodule, and degenerated collagen in necrobiosis lipoidica.” Warschaw KE, Cotton JP. Glossary. In: Farmer ER, Hood AF, eds. Pathology of the Skin, 2nd ed. New Yor…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Wegener’s Granulomatosis?

…ascular granuloma consisted of a central core of necrosis and fibrin and a rim of epithelioid histiocytes, lymphocytes, and plasma cells. More recently, Wegener’s granulomatosis has been conceived of as a paucicellular autoimmune process caused…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Urticarial Vasculitis?

…rial. Microscopic examination of skin biopsy specimens showed fibrinoid necrosis of the blood vessel walls, an infiltrate containing polymorphonuclear leucocytes, fragmentation of cell nuclei, and extravasation of erythrocytes.” Soter NA, Austi…

Differential Diagnosis in Dermatopathology

Discussions

…te may be a mix of neutrophils, eosinophils, and lymphocytes, fibrin often is present in the wall of venules, erythrocytes are extravasated in variable number, intraepidermal vesicles appear episodically, stasis changes may be evident, and edema deve…

Differential Diagnosis in Dermatopathology

Leukocytoclastic vasculitis vs. livedo vasculitis

A type of small-vessel vasculitis (venulitis) of the skin, occurring especially in the vicinity of the ankle, characterized at first by purpuric macules and patches that, in time, may become hemorrhagic blisters that ulcerate and heal with white, st…

Differential Diagnosis in Dermatopathology

Discussions

…n a palisade around zones of degenerated collagen, mucin, and fibrin, and both are accompanied at times by fibroplasia. Crucial attributes histopathologic allow the two different inflammatory processes to be distinguished from one another, e.g., comp…

Histologic Diagnosis of Inflammatory Skin Diseases

Selection of the Site

…ls and some nuclear “dust” of neutrophils, but no fibrin in the wall of venules. Although those paltry findings, in themselves, may be sufficient to make a diagnosis of leukocytoclastic vasculitis, if nuclear “dust” is too mea…

Differential Diagnosis in Dermatopathology

Dermatitis herpetiformis vs. Bullous pemphigoid

A type of small-vessel vasculitis (venulitis) of the skin, occurring especially in the vicinity of the ankle, characterized at first by purpuric macules and patches that, in time, may become hemorrhagic blisters that ulcerate and heal with white, st…