Search Results for: fibrin

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Hyalin?

…nosis also is a misnomer; that material is devoid of lipid. In the circumstances just cited, what is reputed to be hyalin is fibrin, necrotic keratocytes, degenerated erythrocytes, fibronectin, basement membrane material, and neutral…

Histologic Diagnosis of Inflammatory Skin Diseases

Septic vasculitis

…y nuclear “dust” of neutrophils, whereas septic vasculitis is devoid of it; leukocytoclastic vasculitis exhibits fibrin within the wall of venules and no thrombi in the lumen of them, whereas in septic vasculitis, fibrin is not found in…

Histologic Diagnosis of Inflammatory Skin Diseases

Erythema nodosum leprosum

…ecause on rare occasions careful scrutiny of sections of tissue from specimens of erythema nodosum leprosum does reveal some fibrin in the wall of small vessels and thrombi in some of their lumen. In most specimens, however, there are no signs of…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Wegener’s Granulomatosis?

…c for Churg-Strauss syndrome. The concept of leukocytoclastic vasculitis is based on changes morphologic in venules, namely, fibrin in the wall of them in conjunction with neutrophils and nuclear “dust” of neutrophils, all of which…

Histologic Diagnosis of Inflammatory Skin Diseases

Radiation dermatitis and panniculitis

…bnormal nuclei and stellate cytoplasm in zones of sclerosis Decreased number of epithelial structures of adnexa Subepidermal fibrin often Vacuolar alteration along the dermoepidermal junction in conjunction with a few scattered lymphocytes…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Urticarial Vasculitis?

…e., nuclear “dust” (leukocytoclasis). Nearly always, erythrocytes are extravasated among the inflammatory cells. Fibrin, however, is not present in the wall of venules in the urticarial stage of leukocytoclastic vasculitis; it appears…

Differential Diagnosis in Dermatopathology

Leukocytoclastic vasculitis vs. livedo vasculitis

A type of small-vessel vasculitis (venulitis) of the skin, occurring especially in the vicinity of the ankle, characterized at first by purpuric macules and patches that, in time, may become hemorrhagic blisters that ulcerate and heal with white,…

Differential Diagnosis in Dermatopathology

Discussions

…of the paucity of inflammatory cells, they sometimes being absent altogether, but they differ from livedo vasculitis because fibrin cannot be discerned in the wall of vessels. Livedo vasculitis must be distinguished from livedo reticularis…

Differential Diagnosis in Dermatopathology

Discussions

…ous fat, whereas granuloma annulare does not. In subcutaneous granuloma annulare, vasculitis of small vessels in the form of fibrin in the wall of venules is present in the center of some palisades, yet the vasculitis in rheumatoid nodule,…

Histologic Diagnosis of Inflammatory Skin Diseases

Selection of the Site

…a sparse perivascular and interstitial infiltrate of neutrophils and some nuclear “dust” of neutrophils, but no fibrin in the wall of venules. Although those paltry findings, in themselves, may be sufficient to make a diagnosis of…