Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Metastasizing Dermatofibroma?

“. . . We conclude that dermatofibromas can very rarely metastasize. Risk factors for metastasis may include relatively large size, high cellularity, and local recurrence. It would appear that metastasizing dermatofibromas behave in an indol…

Histologic Diagnosis of Inflammatory Skin Diseases

Scleromyxedema

Scleromyxedema Synonyms Papular mucinosis Lichen myxedematosus Presentation stereotypical Age and sex Adults of either sex Distribution of lesions Widespread Individual lesions Papules that produce diffuse thickening of the skin Course Protracted Va…

Differential Diagnosis in Dermatopathology

Differential Diagnosis

…of collagen arranged often in short interlacing fascicles 5. Fibrocytes insinuated between markedly thickened collagen bundles at the periphery of the lesion 5. Perineural fibrocytes scattered diffusely among normal collagen bundles at the peripher…

Differential Diagnosis in Dermatopathology

Differential Diagnosis

…ucinous 5. Mast cells increased slightly in loci mucinous 6. Fibrocytes increased slightly and scattered as solitary units in stroma, mucin-rich, mostly in the upper half of the dermis 6. Fibrocytes increased markedly in number with their long axis…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 11.3.1A: Perivascular and interstitial dermatosis + 11.3.1B: Numerous melanophages in conjunction with dull, amphophilic, homogeneous globules in the papillary dermis + 11.3.1C + 11.3.1D = Amyloidosis, macular ┬áThe abs…

Histologic Diagnosis of Inflammatory Skin Diseases

Acroangiodermatitis of Mali/Stewart-Bluefarb syndrome

Acroangiodermatitis of Mali/Stewart-Bluefarb syndrome Presentation stereotypical Age and sex Adults of both sexes Distribution of lesions Localized to the lower part of the legs bilaterally, especially the toes Arrangement of lesions Discrete Indivi…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 10.16.1A: Diffuse dermatitis, granulomatous and fibrosing + 10.16.1B: Purple intranuclear and intracytoplasmic inclusions in a fibrocyte = Cytomegalic inclusion disease The attributes cytopathologic of cytomegalic inclu…