Histologic Diagnosis of Inflammatory Skin Diseases

Silica granuloma

Silica granuloma Presentation stereotypical Age and sex No predilection Distribution of lesions On exposed sites usually Individual lesions Papules and nodules Course Protracted because the foreign body persists in the skin Findings histopathologic…

Histologic Diagnosis of Inflammatory Skin Diseases

Xanthogranuloma/Reticulohistiocytic granuloma

A systemic inflammatory process involving venules by deposits of fibrin within their wall in conjunction with neutrophils and nuclear “dust” of neutrophils in the dermis and, at times, the subcutaneous fat. The clinical manifestations ar…

Histologic Diagnosis of Inflammatory Skin Diseases

Granuloma annulare

A systemic inflammatory process involving venules by deposits of fibrin within their wall in conjunction with neutrophils and nuclear “dust” of neutrophils in the dermis and, at times, the subcutaneous fat. The clinical manifestations ar…

Histologic Diagnosis of Inflammatory Skin Diseases

Pyogenic granuloma

A systemic inflammatory process involving venules by deposits of fibrin within their wall in conjunction with neutrophils and nuclear “dust” of neutrophils in the dermis and, at times, the subcutaneous fat. The clinical manifestations ar…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 10.43.1A: Nodular dermatitis, granulomatous + 10.43.1B: Interstitial and palisaded array of histiocytes around loci of deposits of mucin and degeneration of collagen = Granuloma annulare This is a presentation stereotypical of gran…

Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Nodular and Diffuse Dermatitis

…y of epithelioid histiocytes, which qualifies this process as granulomatous, the actual disease being sarcoidosis. Figure 5.176 A&B. A nodule made up of epithelioid histiocytes: lichen nitidus. A nodule, in this instance composed mostly of epi…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Langerhans’ Cell Granulomatosis?

…cytes encountered in healthy skin, in histiocytoma or various granulomatous processes are devoid of the granules. It could be inferred that histiocytes produce the granules only in certain proliferative conditions (for instance, in HX) but this would…

Histologic Diagnosis of Inflammatory Skin Diseases

Errors and Reasons

…s-cell carcinoma analogous to solar keratosis. Error: Actinic granuloma is different from granuloma annulare. Reason: The features of it clinical and the findings of it histopathologic are those of granuloma annulare, the elastophagocytosis claimed t…

Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Subcutaneous Fat: Panniculitis

…s fully developed lesion of erythema nodosum. The well-formed granulomas in lobules are reminiscent of those of subcutaneous sarcoidosis, but the widened fibrotic septa allow erythema nodosum to be identified for what it is. Figure 5.389 A&B….

Histologic Diagnosis of Inflammatory Skin Diseases

Applicable Terms

…suppurative infundibulitides, such as Majocchi’s “granuloma”; and (3) vesicants such as the oil, cantharidin, on surface epidermal keratocytes. Whenever neutrophils enter the epidermis in large numbers, the effects of enzymes releas…