Therapeutic Strategies in Dermatology

Viral Exanthems: Initial Evaluation

Initial Evaluation Patients with a viral exanthem often present with a non-specific morbilliform eruption. In some cases, the skin disease as part of a constellation of other symptoms may indicate a specific viral etiology. Measles German m…

Therapeutic Strategies in Dermatology

Erythema Multiforme: Clinical Cases

Clinical Cases Case 1 24-year-old woman with history of recurrent orolabial herpes infection Presents with asymptomatic lesions on the palms (approximately 8 on each hand) and soles (approximately 4-5 on each foot) that developed one day after n…

Therapeutic Strategies in Dermatology

Viral Exanthems: Key Points

Key Points Viral exanthems are usually asymptomatic and self-limited, and therapy usually is not required. Recognition of the viral etiology is mostly indicated for counseling patients regarding the course of the infection and regarding contact pre…

Therapeutic Strategies in Dermatology

Nummular Dermatitis: Overview

…verse origin, including atopic dermatitis, dyshidrotic eczema, hand eczema, seborrheic dermatitis, and stasis dermatitis (see appropriate chapters for descriptions of therapy for these disease entities). Atopic dermatitis in the infant and child may…

Histologic Diagnosis of Inflammatory Skin Diseases

Hand-foot-and-mouth disease

Hand-foot-and-mouth disease Synonyms Enteroviral vesicular stomatitis with exanthem Presentation stereotypical Age and sex Children usually under the age of 10 years and of both sexes; parents of those children affected sometimes Distribution of les…

Histologic Diagnosis of Inflammatory Skin Diseases

Hand-foot-and-mouth disease

A proliferation of abnormal Langerhans’ cells that may affect internal organs, e.g., the spleen, liver, and bone, sometimes with fatal outcome, as well as the skin, where lesions usually manifest themselves as purpuric papules or ulcers that m…

Histologic Diagnosis of Inflammatory Skin Diseases

Graft-versus-host disease/Eruption of lymphocyte recovery

…y be nearly identical with findings in acute graft-versus-host disease, and sclerodermatous changes of chronic graft-versus-host disease may be indistinguishable from those of scleroderma. Erythema multiforme usually has a normal granular and cornifi…

Differential Diagnosis in Dermatopathology

Pagetoid Bowen’s disease vs. Extramammary Paget’s disease

A proliferation of abnormal Langerhans’ cells that may affect internal organs, e.g., the spleen, liver, and bone, sometimes with fatal outcome, as well as the skin, where lesions usually manifest themselves as purpuric papules or ulcers that m…