Search Results for: langerhans\\' cells

Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Nodular and Diffuse Dermatitis

…ive to nuclei of lymphocytes of lymphomatoid papulosis and of Langerhanscells of histiocytosis X a distinctiveness so special that diagnosis of those diseases cannot be accomplished without notice having been taken of them. The stereotypical…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Verruciform Xanthoma?

…tochemistry. By immunohistochemistry studies, the predominant cells in the inflammatory infiltrate were T cells. The foam cells were of monocyte/macrophage lineage. S-100-positive (Langerhans) cells were occasionally found in the suprabasal layer of…

Histologic Diagnosis of Inflammatory Skin Diseases

Errors and Reasons

…pathogenetically. Error: Histiocytosis X is better designated Langerhans” cell granulomatosis. Reason: Langerhanscells are dendritic cells, not histiocytes, and, therefore, a proliferation of those cells does not qualify as a granuloma;…

Histologic Diagnosis of Inflammatory Skin Diseases

Urticaria pigmentosa

…istiocytosis X also is made up of a population of mononuclear cells joined often by eosinophils and neutrophils, but abnormal Langerhanscells of that condition have kidney-shaped nuclei and abundant amphophilic cytoplasm devoid of granules. T…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Histiocytoses?

…ophage. Histiocytosis X is a benign proliferation of abnormal Langerhanscells and, for that reason, is known in some quarters, inaccurately, as “Langerhans’ cell granulomatosis.” Although the condition can be diagnosed for w…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Dermal Papilla?

…20;Historically, the hair germ has been defined as a group of cells located at the base of the telogen follicle in close contact with the dermal papilla.” Lavker RM, Miller S, Wilson C, et al. Hair follicle stem cells: their location, role in h…