Histologic Diagnosis of Inflammatory Skin Diseases

Errors and Reasons

Error: Abortive is an accurate modifier of particular pathologic processes, e.g., abortive dermatofibroma, abortive morphea, and abortive T-cell lymphoma. Reason: The idea itself is abortive! For example, what is called “abortive T-cell lympho…

Histologic Diagnosis of Inflammatory Skin Diseases

Applicable Terms

ABSCESS [L. abscessus (a going away)]: Clinically, a circumscribed collection of pus and histopathologically a localized collection of neutrophils. An abscess may form in the epidermis, both surface and infundibular, eccrine ducts, dermis, and subcu…

Histologic Diagnosis of Inflammatory Skin Diseases

Subcutaneous T-cell lymphoma

Subcutaneous T-cell lymphoma Synonyms Subcutaneous panniculitis-like lymphoma Presentation stereotypical Age and sex Mostly women in the third and fourth decades of life Distribution of lesions Extremities, trunk, face, neck, and breasts Arrangement…

Dermatology Practical & Conceptual

From the Dermatologikum Hamburg: Quiz

The patient A 44-year-old man presented to the clinic with complaints of “sun allergy” following a weekend of photo-exposure without use of any sunscreens. He said that the lesions started as blisters, became reddish and progressed to h…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Benign and Malignant Cells?

“Tumor cells, benign or malignant, growing in vitro usually do not show any structural features that are pathognomonic of neoplasia.” Diamandopoulos GT. Neoplasia. In: Kissane JM, ed. Anderson’s Pathology. 8th ed. St. Louis, MO:…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 10.102.1A: Perivascular and interstitial dermatitis, neutrophils mostly + 10.102.1B: Neutrophils accompanied by scant nuclear “dust” but by edema marked in the papillary dermis = Sweet’s syndrome ┬áThis can be judg…

Histologic Diagnosis of Inflammatory Skin Diseases

Urticaria pigmentosa

Urticaria pigmentosa Synonyms Mastocytosis Presentation stereotypical Age and sex All ages and both sexes, but mostly nodules and blisters in infants and children, and mostly macules and papules in adults Distribution of lesions Localized or widespr…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Eosinophilic Cellulitis (Wells’ Syndrome)?

“This is a study of the clinical features of four patients in the light of particular cutaneous histopathology. The characteristic eruption is periodic, tending to recur every few months, usually without systemic symptoms. The acute state of…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Cutaneous T-cell Lymphoma?

“There has been a tendency in recent years to phase out the term ‘mycosis fungoides’ and replace it with peripheral cutaneous T-cell lymphoma (CTCL).” Santa Cruz DJ, Hurt MA. Neoplasms of the skin. In: Sternberg SS, ed. Dia…

Histologic Diagnosis of Inflammatory Skin Diseases

Precepts Adjunctive to the Algorithmic Method

Certain basic concepts that pertain to the method recommended here for diagnosis of inflammatory diseases of the skin and subcutaneous fat deserve mention. First, it is advantageous to examine sections of tissue, from the very outset, without refere…