Histologic Diagnosis of Inflammatory Skin Diseases

Images

….90.1A: Perivascular dermatitis, psoriasiform + 10.90.1B: Lymphocytes and neutrophils around venules, dilated tortuous capillaries in edematous dermal papillae, spongioform pustules, and tiers of neutrophil-containing mounds of parakeratosis = Ps…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…d and interstitial patterns of granulomatous inflammation and lymphocytes positioned around venules of both plexuses. 10.43.2A: Nodular dermatitis, granulomatous + 10.43.2B: Histiocytes in a palisade around a focus of both abundant mucin an…

Histologic Diagnosis of Inflammatory Skin Diseases

Lymphomatoid papulosis

…deep, perivascular and interstitial mixed infiltrate of small lymphocytes, abnormal lymphocytes and, often, plasma cells, neutrophils, and eosinophils Abnormal lymphocytes with notably large pleomorphic nuclei, many with a cerebriform outline Some a…

Histologic Diagnosis of Inflammatory Skin Diseases

Syphilis

…a stain. Secondary syphilis Mycosis fungoides consists of lymphocytes mostly, rather than of histiocytes and plasma cells. Mucha-Habermann disease is composed almost entirely of lymphocytes, rather than mostly of histiocytes and plasma cells….

Histologic Diagnosis of Inflammatory Skin Diseases

Limitations of the Algorithmic Method

…superficial perivascular infiltrate made up entirely of small lymphocytes (see Fig. 5.150). On the basis of those findings alone, there are times when a judgment with utter certainty cannot be made about whether the process is inflammatory or neoplas…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 10.64.1A: Nodular dermatitis, lymphocytes predominate + 10.64.1B: Small lymphocytes mostly = Lymphocytoma cutis  At scanning magnification, the infiltrate of lymphocytes in the reticular dermis can be told to follow the course of p…

Histologic Diagnosis of Inflammatory Skin Diseases

Lupus erythematosus

…being associated with but paltry perivascular infiltrates of lymphocytes. Reticular erythematosus mucinosis simply is a variation clinical on the same theme. Lupus hypertrophicus is markedly hyperkeratotic discoid lupus erythematosus (which, unlike…

Histologic Diagnosis of Inflammatory Skin Diseases

Lichen planus-like keratosis

…dings histopathologic Superficial perivascular infiltrate of lymphocytes Patchy lichenoid infiltrate of lymphocytes Melanophages and necrotic keratocytes in the upper part of the dermis often Vacuolar alteration at the dermoepidermal junction and in…