Search Results for: melanocytes

Histologic Diagnosis of Inflammatory Skin Diseases

Hair Follicles

…k of a follicular bulb consists of matrical cells among which melanocytes are interspersed (Figs. 1.25 and 1.26). The base of a bulb encloses a follicular papilla formed of connective tissue in the shape of an inverted pinecone. When a follicle is in…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Lentigo Maligna?

…characterized by an increase in number of structurally normal melanocytes per unit area, which is associated with an irregular, uniform tan, freckle-like, gross lesion. This initial phase may be said to constitute the stage of premalignant hyperplasi…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Radial Growth Phase versus Vertical Growth Phase of Melanoma?

…growth phase disease was that some aggregations of neoplastic melanocytes within the dermis must be larger than those in the epidermis. Step sections through a melanoma, however, often result in turning that argument on its head; nests of melanocytes

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Halo Phenomenon?

…epidermis are just like those of vitiligo, to wit, absence of melanocytes and, therefore, of melanin. En route to regression of the nevus, irrespective of type of it, a patchy infiltrate of lymphocytes usually permeates the abnormal melanocytes of th…

Differential Diagnosis in Dermatopathology

Discussions

…ave several attributes in common, including nests of abnormal melanocytes in the epidermis (scattered often above the dermoepidermal junction and sometimes being present at all levels of the epidermis) and the dermis, some neoplastic melanocytes in m…

Differential Diagnosis in Dermatopathology

Discussions

…a face (so-called lentigo maligna) are both proliferations of melanocytes in which nests tend to form in a hyperpigmented epidermis and melanophages accumulate in a thickened papillary dermis. Junctional nevi of all types present themselves clinicall…

Dermatology Practical & Conceptual

Acral melanoma with hyperkeratosis mimicking a pigmented wart

…Histopathologically the lesion was characterized by nests of melanocytes with considerable nuclear atypia and mitoses. We thus established a diagnosis of melanoma. A detailed inspection of the remaining lesion revealed surrounding pigmented macules…

Dermatology Practical & Conceptual

Strategies for early recognition of cutaneous melanoma-present and future

…neous melanoma is a highly aggressive malignant tumor of skin melanocytes with an increasing incidence in most countries of the world, especially in the fair-skinned populations. Despite all preventive and therapeutic efforts, malignant melanoma is s…