Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Lentigo Maligna?

…, it satisfies all the criteria for melanoma in situ: nests of melanocytes within the epidermis are not equidistant from one another, vary considerably in size and shape, and have become confluent in loci. Moreover, melanocytes disposed as solitary u…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Radial Growth Phase versus Vertical Growth Phase of Melanoma?

…growth phase disease was that some aggregations of neoplastic melanocytes within the dermis must be larger than those in the epidermis. Step sections through a melanoma, however, often result in turning that argument on its head; nests of melanocyte…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Halo Phenomenon?

…epidermis are just like those of vitiligo, to wit, absence of melanocytes and, therefore, of melanin. En route to regression of the nevus, irrespective of type of it, a patchy infiltrate of lymphocytes usually permeates the abnormal melanocytes of t…

Differential Diagnosis in Dermatopathology

Discussions

…. The cells that form nests in a junctional nevus are abnormal melanocytes, i.e., they make melanin and have all the ultrastructural and biochemical characteristics of melanocytes. To refer to them or their intradermal relatives as “nevus cells…

Differential Diagnosis in Dermatopathology

Discussions

…have several attributes in common, including nests of abnormal melanocytes in the epidermis (scattered often above the dermoepidermal junction and sometimes being present at all levels of the epidermis) and the dermis, some neoplastic melanocytes in…

Dermatology Practical & Conceptual

Acral melanoma with hyperkeratosis mimicking a pigmented wart

…ed hyperkeratosis and proliferating nests composed of atypical melanocytes within the epidermis (Figure 3A). Nests ascending into the stratum corneum were also seen (Figure 3B). Atypical melanocytes forming nests demonstrated substantial nuclear atyp…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Dysplasia?

…lesions is the presence of cytologic atypia, or dysplasia, of melanocytes.” (Greene et al. Lancet 1980). In 1981 they stated that “dysplasia is used as a synonym for melanocytic atypia rather than for hyperplasia of atypical melanocytes….