Search Results for: melanocytes

Histologic Diagnosis of Inflammatory Skin Diseases

Hair Follicles

…not contain melanosomes. Although melanocytes in considerable numbers are interspersed among matrical cells in the bulb, few melanocytes are found along the course of the stem and the isthmus; in the infundibulum, melanocytes are disposed in a…

Melanocytic nevi and melanoma: overlapping criteria—the degree is the key

Melanocytic nevi and melanoma: overlapping criteria—the degree is the key

…igure 2. Melanocytic nevus on the back of a 60 year-old male. (A) (H&E) There are round and elongated confluent nests of melanocytes along with crowded solitary melanocytes with monomorphous small, round-oval nuclei with paltry cytoplasm, at the…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Lentigo Maligna?

…rmis are not equidistant from one another, vary considerably in size and shape, and have become confluent in loci. Moreover, melanocytes disposed as solitary units predominate over nests in some high-power fields, and some melanocytes are present…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Radial Growth Phase versus Vertical Growth Phase of Melanoma?

…s III (neoplastic melanocytes filling the papillary dermis and causing the reticular dermis to become bowed), IV (neoplastic melanocytes within the reticular dermis), and V (neoplastic melanocytes in the subcutaneous fat). Changing the names to…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Halo Phenomenon?

…ry different from those of Clark, to wit, the silhouette of a benign neoplasm, slight elevation, and confinement of nests of melanocytes with small, oval, monomorphous nuclei to the dermoepidermal junction and the papillary dermis. The changes in…

Differential Diagnosis in Dermatopathology

Discussions

…bove the dermoepidermal junction and sometimes being present at all levels of the epidermis) and the dermis, some neoplastic melanocytes in mitosis, and an infiltrate of lymphocytes in the dermis. In actuality, nuclear abnormalities of melanocytes

Differential Diagnosis in Dermatopathology

Discussions

…identity. In actuality, those cells conventionally termed “nevus cells,” “nevocytes,” and “nevomelanocytes” are abnormal melanocytes. Lentigo maligna (Hutchinson’s freckle, melanosis circumscripta…

Acral melanoma with hyperkeratosis mimicking a pigmented wart

Acral melanoma with hyperkeratosis mimicking a pigmented wart

…ually made. Figure 3. (A) Hematoxylin and eosin staining revealed remarkable hyperkeratosis and many large nests of atypical melanocytes at the dermoepidermal junction. (B) Nests of atypical melanocytes ascending into the stratum corneum. (C) The…

Strategies for early recognition of cutaneous melanoma-present and future

Strategies for early recognition of cutaneous melanoma-present and future

…, which results in so-called “non-edged papillae.” (C) CLSM image at the superficial dermis with a large nest of melanocytes (dashed red circle). Within the nest large atypical melanocytes with dark central nucleus are seen. Furthermore,…