Search Results for: morphea

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…les of collagen = Nephrogenic fibrosing dermopathy At scanning magnification, the pattern could be misread easily as that of morphea, the changes in collagen involving the reticular dermis, the septa in the subcutaneous fat, and the fascia. This is…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Overlap Syndromes?

…two diseases sometimes occur together in a single pathologic process. Nowhere is that illustrated better than in the case of morphea and lichen sclerosus et atrophicus; they are not different diseases because lichen sclerosus et atrophicus is…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Perivasculitis?

…a, or localized scleroderma, of the eyelids is an uncommon disease. . . . In the present report a patient with biopsy-proven morphea of both upper eyelids is described. The salient histopathologic features included . . . a moderate lymphocytic…

Histologic Diagnosis of Inflammatory Skin Diseases

Graft-versus-host disease/Eruption of lymphocyte recovery

…eplaced by fibroplasia. The changes sclerodermatous in chronic graft-versus-host disease are indistinguishable from those of morphea as it is encountered in circumstances as dissimilar as in Shulman’s syndrome and porphyria cutanea tarda….

Histologic Diagnosis of Inflammatory Skin Diseases

Limitations of the Algorithmic Method

…hat encircle those of the deep plexus, if that latter plexus is involved at all. Notable exceptions to that general rule are morphea (see Fig. 5.32), necrobiosis lipoidica, and interstitial granulomatous dermatitis with arthritis, many examples of…

Histologic Diagnosis of Inflammatory Skin Diseases

Necrobiosis lipoidica

…which occurs in discrete loci that become surrounded by histiocytes aligned in a palisade. In both necrobiosis lipoidica and morphea, the lower two thirds of the reticular dermis often is involved preferentially. In time, the changes in collagen in…

Histologic Diagnosis of Inflammatory Skin Diseases

Mycosis fungoides

…is. Last, some lymphocytes in mycosis fungoides, unlike the situation in granuloma annulare, may have a cerebriform outline. Morphea differs from interstitial mycosis fungicides by the infiltrate tending to be “bottom heavy” and…