Histologic Diagnosis of Inflammatory Skin Diseases

Images

…magnification, the pattern could be misread easily as that of morphea, the changes in collagen involving the reticular dermis, the septa in the subcutaneous fat, and the fascia. This is not morphea, however, because the number of fibrocytes is incre…

Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Perivascular Dermatitis

See Figs. 5.16 A&B, 5.17 A&B, 5.18 A&B, 5.19 A&B, 5.20 A&B, 5.21 A&B, and 5.22 A&B Figure 5.16 A. Perivascular dermatitis, perivascular only, superficial. B. Perivascular dermatitis, perivascular only, superficial and…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Overlap Syndromes?

…rocess. Nowhere is that illustrated better than in the case of morphea and lichen sclerosus et atrophicus; they are not different diseases because lichen sclerosus et atrophicus is nothing other than a superficial manifestation of morphea! In the cas…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Perivasculitis?

“Pruritic urticarial papules and plaques of pregnancy (PUPPP) was recently defined as an intensely pruritic cutaneous eruption occurring in the third trimester. . . . The overall picture was nonspecific and ranged from one suggestive of eryt…

Histologic Diagnosis of Inflammatory Skin Diseases

Mycosis fungoides

Mycosis fungoides Synonyms Cutaneous T-cell lymphoma Presentation stereotypical Age and Sex Adults usually, although children may be affected. Males preponderant. Distribution of lesions Often widespread, but sometimes localized to a single patch or…

Histologic Diagnosis of Inflammatory Skin Diseases

Graft-versus-host disease/Eruption of lymphocyte recovery

…graft-versus-host disease are indistinguishable from those of morphea as it is encountered in circumstances as dissimilar as in Shulman’s syndrome and porphyria cutanea tarda. Morphea, like erythema multiforme, erythema nodosum, leukocytoclast…

Histologic Diagnosis of Inflammatory Skin Diseases

Necrobiosis lipoidica

…d septa, a finding reminiscent of changes in the panniculus of morphea. In morphea, however, septa are devoid of granulomatous inflammation and they are widened by crowded, thickened bundles of collagen oriented parallel to one another. So-called sub…

Histologic Diagnosis of Inflammatory Skin Diseases

Limitations of the Algorithmic Method

The algorithmic method proposed in these pages and predicated on patterns histopathologic is intended to be more than just a guide to diagnosis of particular pathologic processes in skin and subcutaneous fat; it is meant to serve as a springboard fo…