Histologic Diagnosis of Inflammatory Skin Diseases

The Algorithmic Method

…nning and high magnifications. Plasma cells in this lesion of necrobiosis lipoidica are seen, at scanning magnification, to be more pale than lymphocytes but more dark than histiocytes, and, when in clusters, not equidistant from one another because…

Histologic Diagnosis of Inflammatory Skin Diseases

Errors and Reasons

…ot unique to them (witness diseases as different from them as necrobiosis lipoidica and necrobiotic xanthogranuloma, both of which affect profoundly collagen and blood vessels). Error: Colloid is a distinct and distinctive substance. Reason: Colloid…

Histologic Diagnosis of Inflammatory Skin Diseases

Applicable Terms

…hese changes in collagen are seen in conditions as unalike as necrobiosis lipoidica, necrobiotic xanthogranuloma, and severe burns of any cause, and as a consequence of the effects of neutrophils, in large number, on collagen, as occurs in “Chu…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…no mucin is detectable in association with the granulomas of necrobiosis lipoidica. 10.43.4A: Nodular dermatitis, granulomatous + 10.43.4B: Histiocytes in palisaded array around a focus of abundant mucin = Granuloma annulare The changes i…

Histologic Diagnosis of Inflammatory Skin Diseases

Scar

…ction alopecia, xanthogranulomas, erythema elevatum diutinum, necrobiosis lipoidica, and erythema nodosum. In brief, fibrosing inflammation is a term generic for any inflammatory process marked by fibrosis, whereas scar is a designation for a constel…

Histologic Diagnosis of Inflammatory Skin Diseases

Rheumatoid nodule

…center of palisades of histiocytes and scant, if any, fibrin. Necrobiosis lipoidica shows striking degeneration of collagen in the center of palisades of histiocytes in evolving lesions and thickened bundles of collagen in the center of palisades in…