Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 10.39.1A: Infundibulitis, spongiotic, and peri-infundibulitis + 10.39.1B: Predominance of lymphocytes in and around infundibula dilated by corneocytes = Fox-Fordyce disease Spongiosis in the wall of an infundibulum near the site wh…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…1.1B: A comedo in association with granulomatous and fibrosing peri-infundibulitis = Acne vulgaris Many of the findings pictured here may be seen in other types of suppurative infundibulitis, but the presence of a comedo in the context of the sup…

Histologic Diagnosis of Inflammatory Skin Diseases

Hair Follicles

…undles of collagen that encircle the follicle. Collagen in the perifollicular sheath, like that in the papillary dermis, is predominantly Type III. Scattered in the perifollicular sheath are fibrocytes that are responsible for producing it and capill…

Histologic Diagnosis of Inflammatory Skin Diseases

Majocchi’s granuloma

Majocchi’s granuloma Synonyms Nodular granulomatous perifolliculitis Tinea der unterschenkel Perifollicular granuloma Trichophytic granuloma Comment The term “Majocchi’s granuloma” is misleading because it implies that the…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…is pilaris and is noted palpably on palpation. 11.10.2A: Perivascular dermatitis and peri-infundibulitis + 11.10.2B: A plug of cornified cells in a thinned infundibulum that in loci no longer in contiguity with adjacent dermis = Keratosis p…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…infundibular epidermis, as is the case here. 10.47.10A: Perivascular dermatitis and peri-infundibulitis + 10.47.10B: Ballooned keratocytes with “margination” of nuclear chromatin and multinucleate corneocytes in an infundibulum…

Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Fibrosing Dermatitis

…of acne keloidalis: sequence chronologically from suppurative infundibulitis to fibroplasia. The sequence, over a period of many years, of suppurative infundibulitis, extrusion of neutrophils in large number from the infundibulum, granulomatous infl…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…ar folliculitis.” It seems, however, to be a suppurative infundibulitis fundamentally to which has been attracted large numbers of eosinophils. 10.27.2A: Perivascular and interstitial dermatitis + 10.27.2B: Lymphocytes and eosinophils…

Histologic Diagnosis of Inflammatory Skin Diseases

Rosacea

…s associated with lymphocytes in infundibula Fully developed Perivascular infiltrates of lymphocytes and, sometimes, plasma cells Suppuration in some infundibula Well-circumscribed collections of epithelioid histiocytes, usually in peri-infundibula…

Differential Diagnosis in Dermatopathology

Differential Diagnosis

…es involved usually in a 4 mm biopsy specimen 2. Suppurative infundibulitis prominent 2. Suppurative infundibulitis and granulomatous peri-infundibulitis prominent 3. Peri-infundibulitis not consequential 3. Peri-infundibulitis often predominant…