Dermatology Practical & Conceptual

Spitz and Reed nevi: acquired or congenital?

…te melanocytes are an expected finding in congenital type nevi like Unna or Miescher nevi, but virtually never seen in acquired nevi like Clark’s [1]. Thus, the occurrence of large and multinucleate melanocytes in about 25% of the lesions analy…

Histologic Diagnosis of Inflammatory Skin Diseases

Algorithms Predicated on “Nonspecific” Findings

In this section, algorithms used to reach specific diagnosis are predicated on “nonspecific” findings recognized best at higher magnification. Other changes requisite for specific diagnoses, i.e., denominators that are essential, then ar…

Histologic Diagnosis of Inflammatory Skin Diseases

Sebaceous Units

…nds do not become noticeably smaller as the turnover of mature sebocytes decreases. In conclusion, the amount and rate of sebaceous secretion are governed by the action of androgens on immature sebocytes. Sebum is not known to have any role physiolog…

Histologic Diagnosis of Inflammatory Skin Diseases

Mycosis fungoides

…ify manifestations clinical of lichen planus with designations like hypertrophic and atrophic, so, too, it is with terms like “large-plaque parapsoriasis,” “small plaque parapsoriasis,” and “alopecia mucinosa” for…

Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Perivascular Dermatitis

See Figs. 5.16 A&B, 5.17 A&B, 5.18 A&B, 5.19 A&B, 5.20 A&B, 5.21 A&B, and 5.22 A&B Figure 5.16 A. Perivascular dermatitis, perivascular only, superficial. B. Perivascular dermatitis, perivascular only, superficial and…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 10.63.1A: Perivascular dermatitis, interface, vacuolar + 10.63.1B: Smudged appearance of the dermoepidermal junction, focally thinned epidermis, and plentiful mucin throughout the dermis = Lupus erythematosus, discoid  The presence…

Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Subcutaneous Fat: Panniculitis

See Fig. 5.385 A-C. Figure 5.385 Patterns of panniculitis. A. Septal mostly. B. Lobular mostly. C. Septal and lobular “equally.” At scanning magnification, the normal subcutaneous fat is seen to be segregated by struts of fibrous tiss…

Dermatology Practical & Conceptual

The dermatoscopic universe of basal cell carcinoma

Abstract Following the first descriptions of the dermatoscopic pattern of basal cell carcinoma (BCC) that go back to the very early years of dermatoscopy, the list of dermatoscopic criteria associated with BCC has been several times updated and rene…