Search Results for: spongiosis

Histologic Diagnosis of Inflammatory Skin Diseases

Miliaria rubra

…n acrosyringium is sprinkling of neutrophils in the interstitium of a superficial mixed-cell infiltrate that reposes beneath spongiosis in an epidermis. Even then, unless spongiosis is present in at least one acrosyringium, it is impossible to make…

Histologic Diagnosis of Inflammatory Skin Diseases

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…is is characterized by a blister that forms above the basal layer and houses numerous acantholytic cells without any sign of spongiosis, there are instances in which the dominant findings are of spongiosis and spongiotic vesicles, as is the…

Histologic Diagnosis of Inflammatory Skin Diseases

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…eutrophils predominant + 10.88.4B: Spongiosis mediated by neutrophils and edema of the papillary dermis = Prurigo pigmentosa Spongiosis is mediated commonly by lymphocytes or eosinophils. In prurigo pigmentosa, spongiosis is present early in the…

Histologic Diagnosis of Inflammatory Skin Diseases

Pemphigus vulgaris

…may in a condition wholly unrelated to it, namely, Grover’s disease. Last, it should be remembered that an analogue of spongiosis with eosinophils (badly termed “eosinophilic spongiosis”) that occurs in urticarial lesions of…

Histologic Diagnosis of Inflammatory Skin Diseases

Toxic shock syndrome

…Interface between epidermis and dermis obscured by neutrophils and lymphocytes in company with vacuolar alteration Prominent spongiosis and ballooning associated with neutrophils and lymphocytes; tiny abscesses sometimes Slight acanthosis Individual…

Histologic Diagnosis of Inflammatory Skin Diseases

Confusing Terms (to be Avoided Scrupulously)

…ludes a paragon of eczema in most classifications of it, i.e., lichen simplex chronicus (because that condition is devoid of spongiosis) and atopic eczema (which also is bereft of spongiosis), and it includes pityriasis rosea, erythema annulare…

Histologic Diagnosis of Inflammatory Skin Diseases

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…ermatitis, not of psoriasis. 10.98.6A: Perivascular dermatitis, spongiotic psoriasiform + 10.98.6B: Lymphocytes predominant, spongiosis in both infundibular and surface epidermis, and elongated mounds of scale-crust = Seborrheic dermatitis A lesion…

Histologic Diagnosis of Inflammatory Skin Diseases

Fixed drug eruption

…alteration at the dermoepidermal junction; if extensive, eventuates in subepidermal clefts and subepidermal vesicles Marked spongiosis and ballooning; if ballooning extensive sufficiently, reticular alteration and intraepidermal vesicles ensue…

Histologic Diagnosis of Inflammatory Skin Diseases

Pruritic urticarial papules and plaques of pregnancy

…of pregnancy are formed by sparse perivascular and interstitial infiltrates of inflammatory cells and, at times, by foci of spongiosis. Slight edema in the upper part of the dermis also may contribute. Subtle scale consists of parakeratotic cells….