Histologic Diagnosis of Inflammatory Skin Diseases

Miliaria rubra

…es and interstitial infiltrate of a few scattered neutrophils Spongiosis in one or more acrosyringia; no vesiculation Correlation clinicopathologic In miliaria rubra, tiny discrete papules result from spongiotic foci centered preferentially in acros…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…ly lesion of prurigo pigmentosa; soon they are accompanied by spongiosis and ballooning. 10.88.3A: Perivascular dermatitis, neutrophils predominant + 10.88.3B: Clusters of neutrophils in the epidermis and neutrophils scattered in the inters…

Histologic Diagnosis of Inflammatory Skin Diseases

Pemphigus vulgaris

…in the epidermis in loci Slight edema of the papillary dermis Spongiosis in foci, accompanied by eosinophils nearly invariably, and, at times, by neutrophils Vacuoles between epidermal basal cells and spinous cells, and often between spinous cells, t…

Histologic Diagnosis of Inflammatory Skin Diseases

Toxic shock syndrome

…scattered interstitially Edema of the papillary dermis Slight spongiosis and ballooning in foci epidermal Few neutrophils and lymphocytes in spongiotic foci Fully developed Perivascular and interstitial infiltrate of lymphocytes and neutrophils Mar…

Histologic Diagnosis of Inflammatory Skin Diseases

Confusing Terms (to be Avoided Scrupulously)

…papulovesicular disease characterized histopathologically by spongiosis. That definition, however, excludes a paragon of eczema in most classifications of it, i.e., lichen simplex chronicus (because that condition is devoid of spongiosis) and atopic…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…are an important clue to diagnosis of seborrheic dermatitis. Spongiosis in infundibula is common in the condition and doubtlessly contributes to the formation of scale-crusts at the lips of ostia of infundibula. 10.98.2A: Perivascular and inte…

Histologic Diagnosis of Inflammatory Skin Diseases

Fixed drug eruption

…ermal junction in conjunction with vacuolar alteration Slight spongiosis and ballooning Individual necrotic keratocytes in the basal and spinous layers Cornified layer normal Fully developed Moderately dense perivascular and interstitial mixed-cell…

Histologic Diagnosis of Inflammatory Skin Diseases

Pruritic urticarial papules and plaques of pregnancy

…terstitium that vary in number from few to many. Slight focal spongiosis sometimes Slight focal parakeratosis at times Late Superficial perivascular infiltrate composed mostly of lymphocytes with only a few eosinophils Correlation clinicopathologi…

Histologic Diagnosis of Inflammatory Skin Diseases

Fox-Fordyce disease

…by orthokeratotic cells Acanthosis of infundibular epidermis Spongiosis of infundibular epidermis, including spongiotic vesiculate. Cornoid lamellation in infundibula sometimes Ballooning and vacuolar alteration, and individual dyskeratotic keratocy…