Histologic Diagnosis of Inflammatory Skin Diseases

Factitious dermatitis and panniculitis

…cally as nodules and/or plaques secondary to fat necrosis and suppuration. Persistence of lesions results from progression of the acute inflammatory process to granulomatous inflammation and last to fibrosis. Injury to the skin external by use of a s…

Histologic Diagnosis of Inflammatory Skin Diseases

Our Definition of “Inflammation” and “Inflammatory Disease”

…n is what follows on rupture of an infundibular cyst, namely, suppuration, granulomatous infiltration, and fibrosis; of course, a plug of corneocytes in an infundibulum and a bolus of them in a cyst does not qualify as an inflammatory disease, but ru…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…ndibular cysts were even more formidable. The cysts ruptured, suppuration and granulomatous inflammation ensued, and fibrosis, seen here, followed. In short, rhinophyma begins with formation of infundibular cysts and ends with scarring, often in conj…

Dermatology Practical & Conceptual

Multiple confluent reddish nodules

…cutaneous and deep mycoses, there are no areas of necrosis or suppuration, nor pseudocarcinomatous hyperplasia of the epidermis, unless the biopsy is taken at the edges of an ulcer. The fungus is abundant and easily seen in hematoxylin and eosin stai…

Histologic Diagnosis of Inflammatory Skin Diseases

Rosacea

…cular infiltrates of lymphocytes and, sometimes, plasma cells Suppuration in some infundibula Well-circumscribed collections of epithelioid histiocytes, usually in peri-infundibular location; granulomas surrounded usually by lymphocytes and, sometime…

Histologic Diagnosis of Inflammatory Skin Diseases

Collagen

…cars, keloids, and dermatofibromas; those marked by extensive suppuration and subsequent degeneration of collagen, such as ruptured epidermal (infundibular) and follicular (isthmus-catagen) cysts, deep fungal infections and atypical mycobacterial inf…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…8217;s disease, however, especially those situated on a face, suppuration is centered in and around infundibula. 10.8.2A: Vasculitis, small vessel, neutrophilic + 10.8.2B: Dense perivascular and interstitial infiltrate of lymphocytes, neutr…

Differential Diagnosis in Dermatopathology

Discussions

…fat Coagulation necrosis of adipocytes in conjunction with suppuration in lobules. Later clinical lesions of nodular vasculitis are dusky nodules that ulcerate and heal with hyperpigmented scars that may be topped by scales. The findings histopa…

Histologic Diagnosis of Inflammatory Skin Diseases

Deep fungal infections

…ides associated with granulomatous inflammation and fibrosis. Suppuration in infundibula eventuates often in draining sinuses. No organisms are demonstrable because the process essential is noninfectious. Botryomycosis is a staphylococcal disease tha…