Search Results for: x-linked ichthyosis

Histologic Diagnosis of Inflammatory Skin Diseases

Nerves

…corpuscles, however, mucocutaneous end organs cannot be visualized in sections prepared conventionally and stained by hematoxylin and eosin. The structures, on exposure to silver stains, are seen to consist of loops of loosely wound, branching…

Histologic Diagnosis of Inflammatory Skin Diseases

Ground Substance

Ground substance (extrafibrillar matrix) is finely granular extracellular material that enmeshes fibrillar and cellular components of the body, including those of the dermis, binds water, and provides hydration to the skin. The ground substance of…

Histologic Diagnosis of Inflammatory Skin Diseases

Elastic Fibers

…le measure for the lax, bulging skin characteristic of that condition. Hereditary defects of elastic fibers, such as cutis laxa and pseudoxanthoma elasticum, display loose skin that does not return, in normal fashion, to its original shape after…

Histologic Diagnosis of Inflammatory Skin Diseases

Eccrine Units

…rk cells that have dense granules. The luminal border displays numerous villi. Myoepithelial cells surround secretory ones. (x7000) (Courtesy of Ken Hashimoto, M.D.) Eccrine glands on the palms, soles, axillae, and forehead, unlike those on the rest…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Acquired Epidermolysis Bullosa?

…oring fibrils in addition to the lamina densa and possibly anchoring plaques, and thus has the same distribution as the carboxy terminus of type VII collagen.” The antigen of acquired epidermolysis bullosa subsequently was found to be the…

On the nature of thought processes and their relationship to the accumulation of knowledge, Part XVI-The process of making a diagnosis

On the nature of thought processes and their relationship to the accumulation of knowledge, Part XVI-The process of making a diagnosis

…or against a diagnostic possibility. More about context later. Another type of uncertainty is that which arises in the context of experience (or lack thereof) and is the result of making decisions based on “explicit” or…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Langerhans’ Cell Granulomatosis?

…eculiar organelle that he saw through an electron microscope in the cytoplasm of cells that made up lesions of histiocytosis X. The “X body,” as it was then known, soon came to be recognized as identical with the Langerhans’ cell…

Histologic Diagnosis of Inflammatory Skin Diseases

Lichen planus

…sentation stereotypical Age and sex More common in women, especially young and middle-aged adults Distribution of lesions Flexor surface of forearms and wrists, but no site is exempt. Occurs also at times on the scalp (lichen planopilaris) and in…