Histologic Diagnosis of Inflammatory Skin Diseases

The Algorithmic Method

An algorithm is a method for calculation based on logical thought and orderly sequence, one that can be utilized for diagnosis of diseases of all kinds, including inflammatory ones of the skin. Once a disorder of the skin and/or subcutaneous fat has…

Histologic Diagnosis of Inflammatory Skin Diseases

Destombes-Rosai-Dorfman disease

…cytosis lacks emperipolesis. Reticulohistiocytoma is a type of xanthogranuloma in which cytoplasm of histiocytes is abundant and amphophilic. Xanthogranuloma exhibits neither large numbers of plasma cells nor emperipolesis. Hodgkin’s disease di…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Benign and Malignant Cells?

“Tumor cells, benign or malignant, growing in vitro usually do not show any structural features that are pathognomonic of neoplasia.” Diamandopoulos GT. Neoplasia. In: Kissane JM, ed. Anderson’s Pathology. 8th ed. St. Louis, MO:…

Histologic Diagnosis of Inflammatory Skin Diseases

Advantages of the Algorithmic Method

By utilizing an algorithmic method based mostly on analysis of patterns formed by inflammatory cells, of alterations in epidermal and adnexal epithelium, and of the character of the inflammatory cells themselves, order can be brought to a subject ab…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Churg-Strauss Granuloma and Allergic Granulomatosis?

“The occurrence of a clinical syndrome of severe asthma, fever, and hypereosinophilia, together with symptoms of vascular embarrassment in various organ systems, has been established. . . . The basic anatomical changes . . . consisted of wide…

Histologic Diagnosis of Inflammatory Skin Diseases

Cells That Mediate Inflammation (Inflammatory Cells)

Neutrophils, eosinophils, lymphocytes, plasma cells, and histiocytes are called inflammatory cells because they enter tissue during the process of inflammation. A more exact designation for them is “cells of an inflammatory process”; the…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 10.20.1A: Nodular dermatitis, granulomatous + 10.20.1B: Numerous extravasated erythrocytes, siderophages, and fibrocytes = Dermatofibroma An important finding for diagnosis of a dermatofibroma such as this one is seen at the periph…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Pseudomalignancies?

“The term pseudocancerosis covers a variety of diseases that can be difficult to distinguish from true carcinomas not only clinically but also histologically. However, pseudocanceroses may not only be similar to squamous cell carcinomas but a…