Histologic Diagnosis of Inflammatory Skin Diseases

The Algorithmic Method

…n interstitial granulomatous dermatitis with arthritis and in xanthogranuloma. A potpourri of inflammatory cells, i.e., lymphocytes, histiocytes, plasma cells, eosinophils, and neutrophils, is found in fully developed lesions of granuloma faciale/ery…

Histologic Diagnosis of Inflammatory Skin Diseases

Destombes-Rosai-Dorfman disease

…ytosis lacks emperipolesis. Reticulohistiocytoma is a type of xanthogranuloma in which cytoplasm of histiocytes is abundant and amphophilic. Xanthogranuloma exhibits neither large numbers of plasma cells nor emperipolesis. Hodgkin’s disease dis…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Benign and Malignant Cells?

…or some examples of dermatofibroma applies equally to some of xanthogranuloma, that inflammatory process sometimes exhibiting “monster cells.” Another pitfall for general pathologists is the projection onto analysis of cells, usually neop…

Histologic Diagnosis of Inflammatory Skin Diseases

Advantages of the Algorithmic Method

…e are not the changes of granuloma annulare or of necrobiotic xanthogranuloma. Because we are unable to come to a diagnosis with assurance, the diagnosis issued in a report must be descriptive. Figure 6.13 A&B. Diagnosis not known. The finding…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Churg-Strauss Granuloma and Allergic Granulomatosis?

…generation of collagen and extracellular lipid in necrobiotic xanthogranuloma), whereas other cores do not telegraph a message of specificity (e.g., eosinophils, neutrophils, or both). These various palisaded granulomas are analogous to more than a s…

Histologic Diagnosis of Inflammatory Skin Diseases

Cells That Mediate Inflammation (Inflammatory Cells)

…unction with cholesterol clefts, the diagnosis is necrobiotic xanthogranuloma. How the changes in the locus in the center of the palisade of histiocytes come to occur is not known, but vasculitis of a small vessel may initiate it, and lysosomal enzym…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…rmatofibroma┬áTouton giant cells are not specific for juvenile xanthogranuloma, but may be encountered in other conditions, including dermatofibroma, as shown here. 10.20.25A: Fibrosing dermatitis and panniculitis, mostly septal, with acanthosis…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Pseudomalignancies?

…hey may be inflammatory diseases, such as dermatofibromas and xanthogranulomas with “monster cells.” Irrespective of the essential nature of the process pathologic, the term pseudomalignancy (pseudocarcinoma, pseudolymphoma, pseudosarcoma…