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Dermatology Practical & Conceptual

Langerhans cell histiocytosis-a case report

…comparison to his high school peers. Actually, his height was 1.70 m, being at the 25th percentile according to the CDC 2000 growth chart (height versus age percentile graphic). Figure 1. (A) Slightly elevated erythematous papules covered by yell…

Histologic Diagnosis of Inflammatory Skin Diseases

Factitious dermatitis and panniculitis

…atures and, in a sense, is a type of artefactual panniculitis. Alpha-1-antitrypsin deficiency panniculitis consists of tender erythematous nodules, plaques, and/or ulcers on the trunk and extremities; although features clinical often are claimed to b…

Histologic Diagnosis of Inflammatory Skin Diseases

Traumatic fat necrosis

….g., oral mucous membranes secondary to sucking on a popsicle. Alpha-1-antitrypsin deficiency panniculitis is characterized by tender plaques, nodules, and/or ulcers on the trunk and extremities. The lesions look as if they have been induced artifici…

Histologic Diagnosis of Inflammatory Skin Diseases

Acrodermatitis enteropathica

Acrodermatitis enteropathica Synonyms Zinc deficiency Presentation stereotypical Age and sex Infants of both sexes who suffer from an inherited deficiency of zinc; may occur in adults; characterized in infants by a triad of acral dermatitis, alopeci…

Histologic Diagnosis of Inflammatory Skin Diseases

Suggested Readings

…ecular Biology of the Skin. New York: Oxford University Press, 1991. Kupper TS. Immune and inflammatory processes in cutaneous tissues: mechanisms and speculations. J Clin Invest 1990;86:1783-1789. Lambert RW, Granstein RD. Neuropeptides and Langerha…

Histologic Diagnosis of Inflammatory Skin Diseases

Suggested Readings

…hanced expression in fibrotic skin diseases. J Invest Dermatol 1999;113:246-250. Burgeson RE. Type VII collagen, anchoring fibrils, and epidermolysis bullosa. J Invest Dermatol 1993;101:252-255. Ghohestani RF, Hudson BG, Claudy A, Uitto J. The alpha

Clinical Case Studies

About the Editors

…n of dermatology both nationally and internationally. He is an Alpha Omega Alpha Honor Society graduate of Yale University School of Medicine and trained in dermatology at the Massachusetts General Hospital and the Department of Dermatology at Harvar…

Histologic Diagnosis of Inflammatory Skin Diseases

Cells That Mediate Inflammation (Inflammatory Cells)

…polymorphonuclear leukocytes, maturing thus over the course of 10 days. Mature neutrophils then enter the bloodstream, where they circulate for approximately 7 to 10 hours before departing for extravascular tissues, spending there their autumnal hour…

Histologic Diagnosis of Inflammatory Skin Diseases

Necrolytic migratory erythema

Necrolytic migratory erythema Synonyms Erythema necroticans migrans Glucagonoma syndrome Pseudoglucagonoma syndrome Presentation stereotypical Age and sex Middle-aged or elderly persons of both sexes with increased levels of serum glucagon Distrib…

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