Search Results for: alpha-1 antitrypsin deficiency

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Diagnostic utility of Ki-67 and Cyclin D1 immunostaining in differentiation of psoriasis vs. other psoriasiform dermatitis

Diagnostic utility of Ki-67 and Cyclin D1 immunostaining in differentiation of psoriasis vs. other psoriasiform dermatitis

…nostic tool to differentiate psoriasis from NPPD has not yet been reported [5-10]. In another study, hypoxia inducible factor 1 alpha (HIF-1 alpha), which is linked to inflammation through reciprocal interactions with several cytokines, was used as…

Histologic Diagnosis of Inflammatory Skin Diseases

Acrodermatitis enteropathica

…y a triad of acral dermatitis, alopecia, and diarrhea with failure to thrive and disturbances of mentation. Nutritional zinc deficiency, e.g., in premature infants, patients with parenteral nutrition, inflammatory bowel disease. Differential…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Churg-Strauss Granuloma and Allergic Granulomatosis?

…, where the issue is often debated hotly (akin to that of Kyrle’s disease and the panniculitis ostensibly caused by a1 antitrypsin deficiency). If the essential character of allergic granulomatosis will remain forever speculation, as in…

Histologic Diagnosis of Inflammatory Skin Diseases

Cells That Mediate Inflammation (Inflammatory Cells)

…s are the most numerous of the blood leukocytes, making up 60% to 70% of circulating white cells in an adult. A neutrophil is 10 to 12 μm in diameter and possesses a nucleus that typically displays between three and five lobes, and cytoplasm, that…

Histologic Diagnosis of Inflammatory Skin Diseases

Suggested Readings

…ermatopathol 1988;10:319-329. Histocytes DiPietro LA. Wound healing: the role of the macrophage and other immune cells. Shock 1995;4:233-240. Headington JT. The histiocyte: in memoriam. Arch Dermatol 1986;122:532-533. Fibrocytes Metz CN. Fibrocytes:…

Clinical Case Studies

About the Editors

…logy and has had a strong impact on the practice and perception of dermatology both nationally and internationally. He is an Alpha Omega Alpha Honor Society graduate of Yale University School of Medicine and trained in dermatology at the…

Histologic Diagnosis of Inflammatory Skin Diseases

Suggested Readings

…Ersch J, Stallmach T. Assessing gestational age from histology of fetal skin: an autopsy study of 379 fetuses. Obstet Gynecol 1999;94(5 Pt 1):753-757. Johnson CL, Holbrook KA. Development of human embryonic and fetal dermal vasculature. J Invest…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Ichthyoses?

…their fellow dermatologists, the article by them being deemed by the editors of The Archives of Dermatology to be one of the 100 most important publications in the first 100 years of that journal. Curiously, Frost and Van Scott failed to define…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…with these are seen in acrodermatitis enteropathica, pellagra, Hartnup’s disease, kwashiorkor, and maple syrup disease. 10.18.2A: Perivascular dermatitis with acanthosis + 10.18.2B: Pallor of somewhat ballooned keratocytes in a front across…

Histologic Diagnosis of Inflammatory Skin Diseases

Necrolytic migratory erythema

…cal Weight loss, anemia, and adult-onset diabetes are associated with the disorder. Differential diagnosis clinical Acquired deficiency of zinc may occur in persons who suffer from alcoholism, hepatic disease, or malnutrition, but levels of glucagon…

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