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Histologic Diagnosis of Inflammatory Skin Diseases

Darier’s disease and simulators of it

Darier’s disease and simulators of it Synonyms Darier-White disease Presentation stereotypical Age and sex Onset in childhood or adolescence in both sexes Distribution of lesions Symmetrical and widespread, favoring the neck, shoulders, upper…

Histologic Diagnosis of Inflammatory Skin Diseases

Hailey-Hailey disease

…o the suprabasal region, infundibular epidermis and epithelial structures of adnexa are involved by the process, acantholytic cells do not cornify, and there are no scale-crusts as a rule. Grover’s disease exhibits acantholytic dyskeratotic cel…

Histologic Diagnosis of Inflammatory Skin Diseases

Graft-versus-host disease/Eruption of lymphocyte recovery

…y be nearly identical with findings in acute graft-versus-host disease, and sclerodermatous changes of chronic graft-versus-host disease may be indistinguishable from those of scleroderma. Erythema multiforme usually has a normal granular and cornifi…

Histologic Diagnosis of Inflammatory Skin Diseases

Mucha-Habermann disease

…r in both disorders.‚Ä®Features differentiating: Mucha-Habermann disease differs clinically from leukocytoclastic vasculitis by the presence of scales atop papules. Mucha-Habermann disease misdiagnosed clinically as lymphomatoid papulosis and vice vers

Histologic Diagnosis of Inflammatory Skin Diseases

Degos’ disease (malignant atrophic papulosis)

…mbilicated papules, ulcerated papules, and varicelliform white scars Course Skin lesions come and go for years, some persisting as scars characterized colloquially as being porcelain white; systemic disease manifested as the result of infarcts in the…

Histologic Diagnosis of Inflammatory Skin Diseases

Cat-scratch disease

…al epithelium contributes to elevation of the lesion above the surface of the skin. A pustule of cat-scratch disease comes into being when the infiltrate is rich in neutrophils and collections of them form in the epidermis. Differential diagnosis his

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Mucha-Habermann Disease a Lymphocytic Vasculitis?

…ing from pityriasis lichenoides chronica, which is primarily a disease of the epidermis…Very important and never described previously in this disease is the invasion of the vessel walls by lymphocytes. In addition, the endothelial cells are swo…

Histologic Diagnosis of Inflammatory Skin Diseases

Crohn’s disease

Crohn’s disease Synonyms Inflammatory bowel disease Regional ileitis Regional enteritis Chronic cicatrizing enteritis Presentation stereotypical Age and sex Young adults; slight predominance of women Distribution of lesions The poles of the ga…

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