Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Sclerotic Fibroma?

“Nine biopsies revealed a distinctive type of fibroma characterized by an organized pattern of interwoven fascicles of collagen bundles with a laminated or tortuous appearance, embedded in abundant mucin. A number of fibromas showed striking…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Scleroderma?

“Scleroderma is a chronic disease of unknown cause that affects the microvasculature and loose connective tissue and is characterized by fibrosis and obliteration of vessels in the skin, lungs, gastrointestinal tract, kidneys and heart. It m…

Differential Diagnosis in Dermatopathology

Angiolymphoid hyperplasia with eosinophilia vs. Angiosarcoma

A malignant neoplasm of melanocytes that, in the skin, begins as a macule and may become a patch or a papule. A flat lesion of melanoma tends to be asymmetrical, poorly circumscribed with a scalloped, jagged, or notched border, and variegate, mostly…

Differential Diagnosis in Dermatopathology

Nevus verrucosus vs. Acanthosis nigricans

A malignant neoplasm of melanocytes that, in the skin, begins as a macule and may become a patch or a papule. A flat lesion of melanoma tends to be asymmetrical, poorly circumscribed with a scalloped, jagged, or notched border, and variegate, mostly…

Differential Diagnosis in Dermatopathology

Syringocystadenoma papilliferum vs. Hidradenoma papilliferum

A malignant neoplasm of melanocytes that, in the skin, begins as a macule and may become a patch or a papule. A flat lesion of melanoma tends to be asymmetrical, poorly circumscribed with a scalloped, jagged, or notched border, and variegate, mostly…

Differential Diagnosis in Dermatopathology

Ichthyosis vulgaris vs. X-linked ichthyosis

A malignant neoplasm of melanocytes that, in the skin, begins as a macule and may become a patch or a papule. A flat lesion of melanoma tends to be asymmetrical, poorly circumscribed with a scalloped, jagged, or notched border, and variegate, mostly…

Differential Diagnosis in Dermatopathology

Discussions

Syringocystadenoma papilliferum and hidradenoma papilliferum are both apocrine papillated cystadenomas. Clinically, syringocystadenoma papilliferum appears at birth or in early childhood as a crusted, often weeping, verrucous plaque, usually on the…

Differential Diagnosis in Dermatopathology

Discussions

Trichoadenoma and microcystic adnexal carcinoma at times resemble each other sufficiently to pose a dilemma diagnostic, even though the former is a hamartoma and the latter an adenocarcinoma. Both may have several findings histopathologic in common:…