Search Results for: collagen

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Differential Diagnosis in Dermatopathology

Necrobiosis lipoidica vs. Necrobiotic xanthogranuloma

…n hardening of the skin by virtue of thickening of bundles of collagen in the dermis and subcutis. One of those diseases manifests itself as localized or widespread patches and plaques (morphea) and by localized linear lesions (linear scleroderma), w…

Histologic Diagnosis of Inflammatory Skin Diseases

Scar

…or subcutaneous fat, or both Fully developed Thin bundles of collagen accompanied by plump fibrocytes are oriented parallel to the skin surface Dilated venules oriented mostly perpendicular to the skin surface Mucin sometimes abundant Elastic fibers…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Eosinophilic Cellulitis (Wells’ Syndrome)?

…ci in which red debris of granules of eosinophils adherent to collagen bundles, assumed vaguely the appearance of a flame. Because of this constellation of findings, Wells named the condition “recurrent granulomatous dermatitis with eosinophili…

Histologic Diagnosis of Inflammatory Skin Diseases

Foreign body reaction

…ign body reaction that is the most common in the skin. Bovine collagen injected in the skin produces papules at sites of injections, in part as a foreign body reaction but also, so it is claimed, as a localized hypersensitivity reaction to nonhuman c…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…rmatitis (rather than discrete, crowded, thickened bundles of collagen there as is the case in morphea) and by the presence of an increased number of abnormal fibrocytes (rather than a decreased number of seemingly normal ones as in morphea). 10.92.3…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…e interstitium in conjunction with degeneration of bundles of collagen focally = Response to an arthropod assault  Lysosomal enzymes released from eosinophils may cause degeneration of collagen, just as may those poured from neutrophils. That phenome…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…, in palisaded array around foci of extensive degeneration of collagen and extracellular deposits of lipid = Necrobiotic xanthogranuloma  Necrobiosis lipoidica and necrobiotic xanthogranuloma have features in common, among them lymphoplasmacytic infi…

Differential Diagnosis in Dermatopathology

Discussions

In a collagenous type of connective tissue nevus, known also as collagenoma, and in a lesion late in the course of morphea, abnormalities of connective tissue are observed mostly in the dermis. Bundles of collagen are thickened throughout the reticu…

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