Search Results for: collagen

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Differential Diagnosis in Dermatopathology

Necrobiosis lipoidica vs. Necrobiotic xanthogranuloma

…at least two different inflammatory diseases that have in common hardening of the skin by virtue of thickening of bundles of collagen in the dermis and subcutis. One of those diseases manifests itself as localized or widespread patches and plaques…

Histologic Diagnosis of Inflammatory Skin Diseases

Scar

…early lesions), in company with innumerable extravasated erythrocytes, and fibrocytes in conjunction with coarse bundles of collagen, both components being arranged randomly. At the periphery of the poorly circumscribed lesion, histiocytes and…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Eosinophilic Cellulitis (Wells’ Syndrome)?

…t extracellular granules of eosinophils (largely eosinophil major basic protein) adherent to and alternating the staining of collagen fibers. They are not specific for Wells’ syndrome, and can occur in arthropod bites and other disorders with…

Histologic Diagnosis of Inflammatory Skin Diseases

Foreign body reaction

…bilized for the purpose of ingesting the foreign body. Later, fibrosis dominates. Clue to specific diagnosis histopathologic Collagen in a bolus whose attributes morphologic are different from those of normal collagen present in the dermis or…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…llate-shaped fibrocytes and telangiectases in the upper part of the dermis = Radiation dermatitis, chronic The alteration in collagen is present throughout the dermis and in septa of the subcutaneous fat, a distribution similar to that of changes in…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…nd interstitial dermatitis, and lobular panniculitis + 10.5.21B: Thrombi in the lumen of some small vessels, degeneration of collagen, leukocytoclasis, and confluent epidermal necrosis = Response to the “bite” of a spider This dermatitis…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…: Histiocytes, many of them multinucleate and with foamy cytoplasm, in palisaded array around large zones of degeneration of collagen + 10.68.4C + 10.68.4D = Necrobiotic xanthogranuloma Rarely, necrobiosis lipoidica may display striking degeneration…

Differential Diagnosis in Dermatopathology

Discussions

…oriented oblique to the epidermis. Minor deviations from arrangement parallel do not in themselves imply the existence of a collagenous nevus. In a true collagenous nevus, though, malaligned bundles of collagen are numerous, the condition often…

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