1 3 4 5 6 7 10
Differential Diagnosis in Dermatopathology

Necrobiosis lipoidica vs. Necrobiotic xanthogranuloma

A generic term for at least two different inflammatory diseases that have in common hardening of the skin by virtue of thickening of bundles of collagen in the dermis and subcutis. One of those diseases manifests itself as localized or widespread pa…

Histologic Diagnosis of Inflammatory Skin Diseases

Scar

…hrocytes, and fibrocytes in conjunction with coarse bundles of collagen, both components being arranged randomly. At the periphery of the poorly circumscribed lesion, histiocytes and fibrocytes are interposed among thickened bundles of collagen. The…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Eosinophilic Cellulitis (Wells’ Syndrome)?

“This is a study of the clinical features of four patients in the light of particular cutaneous histopathology. The characteristic eruption is periodic, tending to recur every few months, usually without systemic symptoms. The acute state of…

Histologic Diagnosis of Inflammatory Skin Diseases

Foreign body reaction

…gn body reaction that is the most common in the skin. Bovine collagen injected in the skin produces papules at sites of injections, in part as a foreign body reaction but also, so it is claimed, as a localized hypersensitivity reaction to nonhuman…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…the dermis = Radiation dermatitis, chronic  The alteration in collagen is present throughout the dermis and in septa of the subcutaneous fat, a distribution similar to that of changes in collagen in morphea. The latter condition, however, is not ass…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…he interstitium in conjunction with degeneration of bundles of collagen focally = Response to an arthropod assault  Lysosomal enzymes released from eosinophils may cause degeneration of collagen, just as may those poured from neutrophils. That phenom…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

…lasm, in palisaded array around large zones of degeneration of collagen + 10.68.4C + 10.68.4D = Necrobiotic xanthogranuloma  Rarely, necrobiosis lipoidica may display striking degeneration of collagen in zones in the reticular dermis, bu…

Differential Diagnosis in Dermatopathology

Discussions

In a collagenous type of connective tissue nevus, known also as collagenoma, and in a lesion late in the course of morphea, abnormalities of connective tissue are observed mostly in the dermis. Bundles of collagen are thickened throughout the reticu…

Histologic Diagnosis of Inflammatory Skin Diseases

Introduction

…Figure 1.2 Papillary dermis is composed of thin bundles of collagen arrayed haphazardly, in contrast to the deeper reticular dermis, which is made up of thick bundles of collagen arranged in orthogonal pattern. A capillary can be seen in each pap…

1 3 4 5 6 7 10