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Histologic Diagnosis of Inflammatory Skin Diseases

Porphyria cutanea tarda

Porphyria cutanea tarda Presentation stereotypical Age and sex Young and middle-aged adults of both sexes, but mainly women taking estrogens or who are alcoholic Distribution of lesions Blisters on dorsa of hands and feet, pigmentary alterations and…

Differential Diagnosis in Dermatopathology

Metastatic carcinoma from a breast vs. Morpheiform basal-cell carcinoma

A papular and pustular inflammatory process that is centered in follicles and is distributed mostly in the middle third of the face in both vertical and horizontal directions. Among the varied manifestations of rosacea are innumerable telangiectases…

Differential Diagnosis in Dermatopathology

Discussions

…nfundibular rete ridges of dilated pore are devoid of ducts or cysts, whereas the lobules of pilar sheath acanthoma usually contain structures like sebaceous ducts and cysts that house cornified cells. Last, dilated pore shows no evidence of follicul…

Differential Diagnosis in Dermatopathology

Discussions

Trichoepithelioma and infundibulocystic basal-cell carcinoma have many features in common, including relative symmetry, follicular differentiation, elements of both basaloid (trichoblastic) and squamoid (spinous) cells, necrotic neoplastic cells, mi…

Histologic Diagnosis of Inflammatory Skin Diseases

Collagen

More than 70% of the dry weight of the normal dermis consists of collagen (Fig. 1.79). The major collagens are Type I and Type III. Type I collagen has a molecular mass of about 290 KDa and accounts for approximately 80% of the total amount of colla…

Differential Diagnosis in Dermatopathology

Differential Diagnosis

…ilia present often 9. No comedones or milia 10. Infundibular cysts and sinus tracts may be accompaniments 10. No infundibular cysts or sinus tracts 11. Telangiectasias not remarkable 11. Telangiectasias often striking 12. Little or no solar ela…

Histologic Diagnosis of Inflammatory Skin Diseases

Pattern Analysis in Historical Perspective

In 1963, the year that one of us (A.B.A.) began a residency in dermatology, Walter Lever’s textbook, Histopathology of the Skin, was in its third edition and was deemed, universally, to be “the bible” of dermatopathology. To a firs…

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