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Histologic Diagnosis of Inflammatory Skin Diseases

Predominantly Intraepithelial Fluorescence

…helial pattern of fluorescence is of significance and that is diffuse, somewhat coarse, granularity present throughout the epithelium (often most evident in the lower half of the epidermis and with extension, variably, through the basement membrane z…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 10.16.1A: Diffuse dermatitis, granulomatous and fibrosing + 10.16.1B: Purple intranuclear and intracytoplasmic inclusions in a fibrocyte = Cytomegalic inclusion disease The attributes cytopathologic of cytomegalic inclu…

Histologic Diagnosis of Inflammatory Skin Diseases

Identification of Basic Patterns: Skin: Perivascular Dermatitis

…In nephrogenic fibrosing dermopathy, however, the changes are diffuse, not focal, and never are there discrete zones in which a palisade has been formed by the mesenchymal cells. Figure 5.33 A&B. Diagnosis with specificity. A perivascular infi…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 10.7.1A: Diffuse dermatitis, mixed-cell + 10.7.1B: Proliferation of venules lined by plump endothelial cells, a sprinkling of neutrophils and nuclear “dust” of neutrophils, and clumps of granular violaceous material = B…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Anagen Effluvium?

…ed in most quarters as hair loss largely as a complication of systemic therapy with antineoplastic drugs. Unfortunately for a student seeking to understand the subject of anagen effluvium, authors who employ the term all too often propagate misinform…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 10.24.1A: Nodular and diffuse dermatitis, granulomatous + 10.24.1B: Lymphocytes and plasma cells in a collection of histiocytes that exhibit abundant pale cytoplasm = Destombes-Rosai-Dorfman disease Histiocytes with lar…

Histologic Diagnosis of Inflammatory Skin Diseases

Cells That Mediate Inflammation (Inflammatory Cells)

…nse, whereas Th2 cells act to enhance the humoral arm of that system. In several inflammatory diseases, outcome clinically has been shown to correlate with predominance of either Th1 or Th2 cells. For example, in cutaneous leishmaniasis caused by inf…

Histologic Diagnosis of Inflammatory Skin Diseases

Xanthomas

…i). Xanthogranuloma is a type of xanthoma typified by a dense diffuse infiltrate that, when developed fully, houses characteristic multinucleate histiocytes (Touton giant cells), as well as a mix of other inflammatory cells. Clue to specific diagnos…

Histologic Diagnosis of Inflammatory Skin Diseases

Telogen effluvium

…specially women following parturition Distribution of lesions Diffuse loss of hair on the scalp, especially from the parietal region; alopecia sometimes subtle and hardly evident clinically Individual lesions None in skin itself Course Months, with e…

Histologic Diagnosis of Inflammatory Skin Diseases

Dermatofibroma

…ated with desmoplasia. Findings histopathologic Early Dense diffuse infiltrate of histiocytes mostly (often both lipophages and siderophages) in conjunction with innumerable erythrocytes extravasated in a nodule in the reticular dermis and, sometim…

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