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Histologic Diagnosis of Inflammatory Skin Diseases

Lymphedema

Lymphedema Presentation stereotypical Age and sex Adults usually, women more than men Distribution of lesions Distal extremities, legs more than arms; genitalia episodically Arrangement of lesions Diffuse involvement of parts, e.g., elephantiasis In…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 10.24.1A: Nodular and diffuse dermatitis, granulomatous + 10.24.1B: Lymphocytes and plasma cells in a collection of histiocytes that exhibit abundant pale cytoplasm = Destombes-Rosai-Dorfman disease Histiocytes with lar…

Histologic Diagnosis of Inflammatory Skin Diseases

Toxic shock syndrome

Toxic shock syndrome Synonyms TSS Presentation stereotypical Age and sex Women using super-absorbent vaginal tampons especially, but possible in both sexes consequent to any infection by pathogenic bacteria, particularly Staphylococcus aureus, inclu…

Histologic Diagnosis of Inflammatory Skin Diseases

Xanthomas

Xanthomas Presentation stereotypical Age and sex Adults of both sexes Distribution of lesions Localized or widespread Individual lesions Macules, papules, plaques, and nodules Course Some lesions, e.g., eruptive xanthomas, involuting when serum lipi…

Resolving Quandaries in Dermatology, Pathology & Dermatopathology

Anagen Effluvium?

“The follicle tends to respond in an all or none fashion with the notable exception of its response to cancer chemotherapy agents. This is the only known instance in which hair is lost follicles which continue in their growing phase without b…

Histologic Diagnosis of Inflammatory Skin Diseases

Dermatofibroma

Dermatofibroma Synonyms Benign fibrous histiocytoma Fibroma dura Subepidermal nodular sclerosis Histiocytoma Histiocytoma cutis Sclerosing hemangioma Fibroma simplex or fibroma durum Nodulus cutaneus Fibrome en Pastille Dermatofibroma lenticulare De…

Histologic Diagnosis of Inflammatory Skin Diseases

Telogen effluvium

Telogen effluvium Presentation stereotypical Age and sex Any age, but especially women following parturition Distribution of lesions Diffuse loss of hair on the scalp, especially from the parietal region; alopecia sometimes subtle and hardly evident…

Histologic Diagnosis of Inflammatory Skin Diseases

Images

Images 10.16.1A: Diffuse dermatitis, granulomatous and fibrosing + 10.16.1B: Purple intranuclear and intracytoplasmic inclusions in a fibrocyte = Cytomegalic inclusion disease The attributes cytopathologic of cytomegalic inclu…

Histologic Diagnosis of Inflammatory Skin Diseases

Interstitial granulomatous dermatitis with arthritis

Interstitial granulomatous dermatitis with arthritis Synonyms Interstitial granulomatous dermatitis with cutaneous cords and arthritis Rheumatoid papules Palisaded and neutrophilic granulomatous dermatitis Presentation stereotypical Age and sex Ad…

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